Influence of Paracetamol, Sulfanilamide and Ascorbic Acid on the Electrocatalytic Glucose Sensor

Abstract

An electrocatalytic glucose sensor for in vivo application has been developed. The principle of measurement is based on the direct electrochemical oxidation of glucose at a platinum electrode without an enzymatic reaction. In an in vivo experiment with sheep the glucose sensor was tested with respect to its cross-sensitivity towards ascorbic acid, paracetamol and sulfanilamide. The influence of these substances could be reduced by an adapted calibration to such an extent, that the sensor performance could be ensured.

Reduction of acetaminophen interference in glucose sensors by a composite Nafion membrane: demonstration in rats and man

“…Several endogenous analytes, such as ascorbate or urate, or exogenous drug such as acetaminophen, are known to be potentially interfering agents [1]. Their interfering effects have been investigated under in vitro conditions [2][3][4] and for some of them under in vivo conditions [4][5][6]. It has been recognized that cellulose acetate membranes, typically present in the sensor, efficiently eliminate interference by urate and ascorbate [3,7,8].…”