Reduction of acetaminophen interference in glucose sensors by a composite Nafion membrane: demonstration in rats and man

Moatti-Sirat, Dinah; Poitout, Vincent; Thomé, V.; Gangnerau, M. N.; Zhang, Y.; Hu, Yaozhong; Wilson, George S.; Lemonnier, Fabrice; Klein, Jean-Claude; Réach, G.

doi:10.1007/bf00403381

Cited by 51 publications

(30 citation statements)

References 14 publications

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“…Synthetic polymer membranes, such as PU, Nafion, polytetrafluoroethylene, polyethylene glycol (PEG), hydrogels and poly-L-lactic acid, have been confirmed to expand detection range and increase biocompatibility of glucose sensors [18][19][20]. Studies have shown that Nafion and hydrogel have the advantages of enhancing hydration, reducing immune cell adsorption and fibrosis, but also show defects such as more prone to expansion or mineralization [21][22][23][24][25][26]. Therefore, only PU and its modified polymers have been widely used as commercially restriction membranes for glucose transmission with improved linearity [27,28].…”

Section: Introductionmentioning

confidence: 99%

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

et al. 2020

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This study aims to develop an oxygen regeneration layer sandwiched between multiple porous polyurethanes (PU) to improve the performance of implantable glucose sensors. Sensors were prepared by coating electrodes with platinum nanoparticles, Nafion, glucose oxidase and sandwich hierarchically porous membrane with an oxygen supplement function (SHPM-OS). The SHPM-OS consisted of a hierarchically porous structure synthesized by polyethylene glycol and PU and a catalase (Cat) layer that was coated between hierarchical membranes and used to balance the sensitivity and linearity of glucose sensors, as well as reduce the influence of oxygen deficiency during monitoring. Compared with the sensitivity and linearity of traditional non-porous (NO-P) sensors (35.95 nA/mM, 0.9987, respectively) and single porous (SGL-P) sensors (45.3 nA /mM, 0.9610, respectively), the sensitivity and linearity of the SHPM-OS sensor was 98.45 nA/mM and 0.9989, respectively, which was more sensitive with higher linearity. The sensor showed a response speed of five seconds and a relative sensitivity of 90% in the first 10 days and remained 78% on day 20. This sensor coated with SHPM-OS achieved rapid responses to changes of glucose concentration while maintaining high linearity for long monitoring times. Thus, it may reduce the difficulty of back-end hardware module development and assist with effective glucose self-management for people with diabetes.

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Section: Introductionmentioning

confidence: 99%

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

et al. 2020

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“…49 Prior studies have shown that acetaminophen interference can be eliminated when PFSA is used as an inner membrane. 50, 51 For our glucose sensor, PFSA was used as an outer membrane and it was necessary to determine if this structure can also block interference molecules. The arrows in Figure 6 (a) indicate when 0.13 mM of acetaminophen was added to the electrolyte at the end of the experiment.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of a Flexible Amperometric Glucose Sensor Using Additive Processes

Durgan

Matthews

et al. 2015

ECS J. Solid State Sci. Technol.

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This study details the use of printing and other additive processes to fabricate a novel amperometric glucose sensor. The sensor was fabricated using a Au coated 12.7 μm thick polyimide substrate as a starting material, where micro-contact printing, electrochemical plating, chloridization, electrohydrodynamic jet (e-jet) printing, and spin coating were used to pattern, deposit, chloridize, print, and coat functional materials, respectively. We have found that e-jet printing was effective for the deposition and patterning of glucose oxidase inks with lateral feature sizes between ~5 to 1000 μm in width, and that the glucose oxidase was still active after printing. The thickness of the permselective layer was optimized to obtain a linear response for glucose concentrations up to 32 mM and no response to acetaminophen, a common interfering compound, was observed. The use of such thin polyimide substrates allow wrapping of the sensors around catheters with high radius of curvature ~250 μm, where additive and microfabrication methods may allow significant cost reductions.

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“…7 As the research for 1,5-AG detection is preliminary, replicates of detection in complex solutions may yield better accuracy in higher concentrations of blood, requiring only dilution in the final device architecture rather than the use of embedded molecular recognition elements or nonspecific binding protective coatings. 8 As it can be seen in Figure 1, the optimal binding frequency for a particular sensor may not be a single frequency, but rather a range of frequencies with an optimal plateau. Only a more narrow range can be found by evaluating more sensors and determining the average.…”

Section: Discussionmentioning

confidence: 99%

Detection of 1,5-Anhydroglucitol by Electrochemical Impedance Spectroscopy

Adamson

Cook

Belle

2014

J Diabetes Sci Technol

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Background: Multiple markers are used to assess glycemic control in patients with diabetes mellitus (DM). New technology that permits simultaneous detection of multiple biomarkers combined with those used at the point of care indicative of glycemic control, including glycemic variability determined from 1,5-anhydroglucitol measurement, could provide better management and further insight into the disease. Methods:This platform was based on previous research involving glucose detection and uses electrochemical impedance spectroscopy to detect a range of 1,5-anhydroglucitol concentrations at an optimal binding frequency. The enzyme pyranose oxidase was fixed to gold electrodes while a sine wave of sweeping frequencies was induced in purified solutions and in variable presence of whole blood. Results:The optimal binding frequency for the detection of 1,5-anhydroglucitol was found to be 3.71 kHz. The impedance response compared to the concentration of target present was found to have a logarithmic slope of 7.04 with an R-squared value of 0.96. This response includes 2 experimental sets, a single test of a low concentration range and a high concentration range with 5 replicates. The relative standard deviation of the high range varied from 28% to 27% from lowest to highest concentrations. Best detection in complex solutions was found in lower blood concentrations of 0.5% and 1%, but maintained relatively high accuracy in concentrations 5% and 10%. Conclusions:The sensor platform was successfully evaluated at a high dynamic range of 1,5-AG in purified solutions. In the presence of whole blood, lowest percentages yielded the best results indicating that filtering interferents may be necessary in final device architecture.

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Reduction of acetaminophen interference in glucose sensors by a composite Nafion membrane: demonstration in rats and man

Cited by 51 publications

References 14 publications

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

Fabrication of a Flexible Amperometric Glucose Sensor Using Additive Processes

Detection of 1,5-Anhydroglucitol by Electrochemical Impedance Spectroscopy

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