Influence of Pathogen Type on Neonatal Sepsis Biomarkers

Akhmaltdinova, Lyudmila; Kolesnichenko, Svetlana; Lavrinenko, Alyona; Kadyrova, Irina; Avdienko, Olga V.; Panibratec, Lyudmila

doi:10.1155/2021/1009231

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…These results were comparable to pervious results reported by Akhmaltdinova et al (2021) and Hanaganahalli et al, (2018), who showed significant differences in CRP results between the patients and control group. Liu et al, (2019) evaluated the diagnostic value of the CRP test in detecting neonatal septicemia, and suggested that the CRP test has a good diagnostic marker for neonatal sepsis.…”

Section: Discussionsupporting

confidence: 91%

Estimation Of Interleukin 27 And Interleukin 33 Serum Levels In Iraqi Neonatal Sepsis

Ebrahem¹,

Jameel²,

Abbas³

2022

Journal of Pharmaceutical Negative Results

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Bloodstream infections in neonates are one of the most life-threatening infections in them . In this study, a total of 140 blood samples werecollected from neonates at AL-Batoul Teaching Hospital for Gynecology and Pediatrics in Baqubah/Diyala, their ages ranging from 1 dayto 28 days during the period from November 2021 to March 2022. The samples were subjected to a culture study as well as hematologicaland immunological tests (CRP, measuring the level of IL-27 and IL-33). Out of total cultured samples 45 give a positive blood culture, 45specimens from blood culture negative was chosen to become (control group) to be comparable to positive culture specimens. The resultsof the CRP test showed in the Gram-negative bacteria group, the positive result was 76.92% (10 of 13). In the Gram-positive bacteria group,the positive CRP percentage was 84.85% (28 of 33). While in the control group the positive result was 13.33% (6 of 45) , significantdifferences appeared between the compared groups. The results showed the mean levels of IL-27 in the sepsis patient group and controlgroup were (21.14 ± 1.01 and 14.49 ± 0.34 pg/ml, respectively). also showed the mean levels of IL-33 were in the sepsis patient group andcontrol group (250.28 ± 15.75 and 101.16 ± 3.38 pg/ml, respectively). There was a significant increased level of IL-27 and IL-33 in the sepsispatients’ group compared to the control group.

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Section: Discussionsupporting

confidence: 91%

Estimation Of Interleukin 27 And Interleukin 33 Serum Levels In Iraqi Neonatal Sepsis

Ebrahem¹,

Jameel²,

Abbas³

2022

Journal of Pharmaceutical Negative Results

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“…Thirty studies were included in our systematic review and meta-analysis [ 17 – 46 ]. Of them, 15 studies had a control group of healthy neonates [ 19 , 24 – 27 , 29 , 30 , 32 , 33 , 35 – 39 , 46 ], five studies had a control group of neonates who were suspected of sepsis, but eventually had negative blood cultures [ 20 , 28 , 40 , 41 , 44 ], and ten studies included other ICU admitted neonates as the control group [ 17 , 18 , 21 – 23 , 31 , 34 , 42 , 43 , 45 ]. Twenty studies were prospective [ 17 – 25 , 27 , 29 , 30 , 32 , 35 – 38 , 41 , 42 , 44 ] and 10 studies were retrospective [ 26 , 28 , 31 , 33 , 34 , 39 , 40 , 43 , 45 , 46 ].…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis

Chen,

Yasrebinia,

Ghaedi

et al. 2023

BMC Infect Dis

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Introduction The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, measures innate-adaptive immune system balance. In this systematic review and meta-analysis, we aim to analyze the current literature to evaluate the diagnostic role of NLR in neonatal sepsis. Methods PubMed, Web of Science, and Scopus were used to conduct a systematic search for relevant publications published before May 14, 2022. Results Thirty studies, including 2328 neonates with sepsis and 1800 neonates in the control group, were included in our meta-analysis. The results indicated that NLR is higher in neonates with sepsis compared to healthy controls (SMD = 1.81, 95% CI = 1.14–2.48, P-value < 0.001) in either prospective (SMD = 2.38, 95% CI = 1.40–3.35, P-value < 0.001) or retrospective studies (SMD = 0.87, 95% CI = 0.63–1.12, P-value < 0.001) with a pooled sensitivity of 79% (95% CI = 62–90%), and a pooled specificity of 91% (95% CI = 73–97%). Also, we found that NLR is higher in neonates with sepsis compared to those who were suspected of sepsis but eventually had negative blood cultures (SMD =1.99, 95% CI = 0.76–3.22, P-value = 0.002) with a pooled sensitivity of 0.79% (95% CI = 0.69–0.86%), and a pooled specificity of 73% (95% CI = 54–85%). In addition, neonates with sepsis had elevated levels of NLR compared to other ICU admitted neonates (SMD = 0.73, 95% CI = 0.63–0.84, P < 0.001). The pooled sensitivity was 0.65 (95% CI, 0.55–0.80), and the pooled specificity was 0.80 (95% CI, 0.68–0.88). Conclusion Our findings support NLR as a promising biomarker that can be readily integrated into clinical settings to aid in diagnosing neonatal sepsis. As evidenced by our results, restoring balance to the innate and adaptive immune system may serve as attractive therapeutic targets. Theoretically, a reduction in NLR values could be used to measure therapeutic efficacy, reflecting the restoration of balance within these systems.

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“…In the pathophysiology of sepsis, there will be an alteration in the coagulation cascade, which will allow the release of multiple pro-and anti-inflammatory cytokines, leading to thrombus formation [ 32 ]. This will cause fibrinolytic and fibrinogenic substances to be depleted, leading to further platelet destruction.…”

Section: Discussionmentioning

confidence: 99%

Mean Platelet Volume in Neonatal Sepsis: Meta-Analysis of Observational Studies

et al. 2022

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Introduction: Early onset neonatal sepsis (EONS), particularly in preterm sepsis, is a potentially fatal issue. Evaluation of mean platelet volume (MPV) as an EONS predictor was the goal. Methods: Four databases were used to conduct a systematic evaluation of cohort and case–control studies. Up till the end of October 2022, 137 articles were found utilizing the search method. Following the review, 12 studies were included. Leukocytes, MPV, platelets, gender, birth weight, gestational age, mortality, and C-reactive protein (CRP) were all taken into account while analyzing the prediction of EONS. Inverse-variance methodology and the random-effects model were used. Using GRADE, the evidence’s quality was evaluated. Results: Neonatal patients with sepsis had significantly higher MPV levels than do neonates without sepsis (MD 1.26; 95% CI 0.89–1.63; p < 0.001). An increased MPV during the first 24 h postpartum was associated with high CRP values and high risk of neonatal mortality. In the investigations, the MPV cutoff for sepsis patients was 9.95 (SD 0.843). Overall certainty of the evidence was very low. Conclusions: The increased MPV during the first 24 h postpartum may be predictive of EONS and mortality. Future studies are warranted.

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Influence of Pathogen Type on Neonatal Sepsis Biomarkers

Cited by 7 publications

References 21 publications

Estimation Of Interleukin 27 And Interleukin 33 Serum Levels In Iraqi Neonatal Sepsis

Estimation Of Interleukin 27 And Interleukin 33 Serum Levels In Iraqi Neonatal Sepsis

Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis

Mean Platelet Volume in Neonatal Sepsis: Meta-Analysis of Observational Studies

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