The high incidence of respiratory viral infections in children of early, preschool, and primary school age is an urgent problem for practical health care.Purpose. The purpose of the study was to investigate factors contributing to the formation of a group of children who are frequently ill at an early age, born as a result of assisted reproductive technologies.Materials and Methods. The observation group consisted of 60 frequently ill children of the first three years of life born as a result of assisted reproductive technology application. The comparison group consisted of 22 children of similar age born using assisted reproductive technologies, not belonging to the group of frequently ill.Results. Among the endogenous risk factors affecting the increased frequency of acute respiratory infections in children born with the help of assisted reproductive technologies, the most significant are the following: intrauterine hypotrophy (p=0.026), early initiation of formula feeding (p=0.003), allergic diseases (p=0.049). Exogenous risk factors for the formation of a group of frequently ill children born with the use of assisted reproductive technologies are the effect of antibiotic therapy on the child’s immune system, the lack of vaccination against hemophilic infection.Conclusion. Frequently ill children require a comprehensive examination to identify background conditions, timely vaccination, and reasonable prescription of antibiotic therapy.