Influence of pore size of porous titanium fabricated by vacuum diffusion bonding of titanium meshes on cell penetration and bone ingrowth

Chang, Bei; Song, Wen; Han, Tianxiao; Yan, Jun; Li, Fuping; Zhao, Lei; Kou, Hongchao; Zhang, Yumei

doi:10.1016/j.actbio.2016.01.022

Cited by 179 publications

(160 citation statements)

References 46 publications

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“…[140] The process of bone ingrowth is related to the materials' porosity, pore size, and structure. [141] The authors concluded that small pores (about 188 mm) are more likely to promote cell differentiation at the beginning of the implant healing, whereas larger pores (313 μm and more) favor cell proliferation and bone ingrowth. [141] The authors concluded that small pores (about 188 mm) are more likely to promote cell differentiation at the beginning of the implant healing, whereas larger pores (313 μm and more) favor cell proliferation and bone ingrowth.…”

Section: Osseointegration Of Porous Implantsmentioning

confidence: 99%

Porous Titanium Implants: A Review

2018

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Titanium and its alloys are commonly used in almost all disciplines of medicine because of their sufficient biocompatibility and meeting of mechanical requirements. However, dense metallic biomaterials represent only an interfacial connection with host tissue, may develop stress shielding which causes ingrowth of the fibrous tissue, and are prone to microbial adhesion and development of biomaterial associated infections. Therefore, development of a new, porous titanium biomaterial is proposed to improve an implant's interconnection with bone, provide better stabilization, and reduce the risk of the loss of the implant. In this review, recent findings in porous titanium biomaterials engineering are discussed, including the structural and strengthening aspects of titanium alloys. The porosity and design of porous structures, as well as the optimization process are also described. An extensive part of this section is dedicated to manufacturing processes. The next section of the review is devoted to osseointegration of porous implants and surface treatment processes, whose purpose are antibacterial activity or local drug delivery. Summarizing the article, some future predictions have been presented.

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Section: Osseointegration Of Porous Implantsmentioning

confidence: 99%

Porous Titanium Implants: A Review

2018

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“…As a product of osteogenic differentiation, ALP expression level marks osteoblast and bone formation activity. 24,29 The final stage of osteogenic differentiation is the mineralization of ECM, and the mineralized nodule is an important functional marker of mature bone cells. 30 Our study here suggests that the functionalized structure could promote all of these processes.…”

mentioning

confidence: 99%

Osseointegration of layer-by-layer polyelectrolyte multilayers loaded with IGF1 and coated on titanium implant under osteoporotic condition

Huan¹,

Wang²,

Xiao³

et al. 2017

IJN

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Purpose Titanium implant is a widely used method for dental prosthesis restoration. Nevertheless, in patients with systemic diseases, including osteoporosis, diabetes, and cancer, the success rate of the implant is greatly reduced. This study investigates a new implant material loaded with insulin-like growth factor 1 (IGF1), which could potentially improve the implant success rate, accelerate the occurrence of osseointegration, and provide a new strategy for implant treatment in osteoporotic patients. Materials and methods Biofunctionalized polyelectrolyte multilayers (PEMs) with polyethylenimine as the excitation layer and gelatin/chitosan loaded with IGF1 were prepared on the surface of titanium implant by layer-by-layer self-assembly technique. The physical and chemical properties of the biofunctionalized PEMs, the biological characteristics of bone marrow mesenchymal stem cells (BMMSCs), and bone implant contact correlation test indexes were detected and analyzed in vitro and in vivo using osteoporosis rat model. Results PEMs coatings loaded with IGF1 (TNS-PEM-IGF1-100) implant promoted the early stage of BMMSCs adhesion. Under the action of body fluids, the active coating showed sustained release of growth factors, which in turn promoted the proliferation and differentiation of BMMSCs and the extracellular matrix. At 8 weeks from implant surgery, the new bone around the implants was examined using micro-CT and acid fuchsin/methylene blue staining. The new bone formation increased with time in each group, while the TNS-PEM-IGF1-100 group showed the highest thickness and continuity. Conclusion TNS-PEM-IGF1-100 new implants can promote osseointegration in osteoporotic conditions both in vivo and in vitro and provide a new strategy for implant repair in osteoporotic patients.

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“…A possible explanation for the osteostimulative deficits in scaffolds of group B could be the macroporous character of the scaffolds: no bone formation is likely to be induced by scaffolds containing pores with diameters of more than 500 lm [13,25]. An alternative explanation is that the Fig.…”

Section: Discussionmentioning

confidence: 92%

Three-dimensional polymer coated 45S5-type bioactive glass scaffolds seeded with human mesenchymal stem cells show bone formation in vivo

Westhauser

Weis

Prokscha

et al. 2016

J Mater Sci: Mater Med

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45S5-type bioactive glasses are a promising alternative to established substitutes for the treatment of bone defects. Because the three-dimensional (3D) structure of bone substitutes is crucial for bone ingrowth and formation, we evaluated the osteoinductive properties of different polymer coated 3D-45S5 bioactive glass (BG) scaffolds seeded with human mesenchymal stem cells (hMSC) in vivo. BG scaffolds coated with gelatin, cross-linked gelatin, and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) were seeded with hMSC prior to implantation into severe combined immunodeficiency mice. Newly formed bone was evaluated with histomorphometry and micro-computed tomography. Bone formation was detectable in all groups, whereas the gelatin-coated BG scaffolds showed the best results and should be considered in further studies.

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Influence of pore size of porous titanium fabricated by vacuum diffusion bonding of titanium meshes on cell penetration and bone ingrowth

Cited by 179 publications

References 46 publications

Porous Titanium Implants: A Review

Porous Titanium Implants: A Review

Osseointegration of layer-by-layer polyelectrolyte multilayers loaded with IGF1 and coated on titanium implant under osteoporotic condition

Three-dimensional polymer coated 45S5-type bioactive glass scaffolds seeded with human mesenchymal stem cells show bone formation in vivo

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