Influence of Residual Bone on Recombinant Human Bone Morphogenetic Protein‐2–Induced Periodontal Regeneration in Experimental Periodontitis in Dogs

Abstract

The width of residual bone was one of the clinical host factors that affected bone regeneration following BMP implantation. However, it did not affect connective tissue attachment, cementum regeneration, and downgrowth of junctional epithelium.

Tooth-derived stem cells: Update and perspectives

“…The basic components for tissue engineering involve an interactive triad of scaffolds [79][80][81] , signaling molecules [82][83][84] and cells [24,33,41,85] , which play a fundamental role in the regeneration process [24,76,86,87] . Scaffolds serve as a threedimensional template mimicking the extracellular matrix; signaling molecules enhance this cellular activity by stimulating cells to migrate, proliferate and differentiate; and cells provide the machinery synthesis of the extracellular matrix and tissue regeneration [24,75,76,88,89] .…”

A review on endogenous regenerative technology in periodontal regenerative medicine

“…A drug delivery system by means of a combination of polymers and GFs, in many cases, can provide a well-controlled release of its cargo into a local microenvironment to yield desirable concentrations over a period ranging from days to months. Frequently used polymers for the delivery of bioactive factors, particularly for periodontal regeneration, include synthetic materials such as polyglycolic acid (PGA), polylactic acid (PLA) and their copolymers (PLGA) [38e40]; beta-tricalcium phosphate (beta-TCP) [41,42]; and natural polymers such as dextran [43], gelatin [39,44], and collagen [45,46]. There is evidence that a combination of several materials may offer the best opportunity for beneficial clinical outcomes.…”

Bone morphogenetic proteins: The anomalous molecules

“…[4] Recent studies have utilized recombinant human BMP to determine their potential for correcting intrabony, supra-alveolar, furcation, and fenestration defects. [20] However, in most of these studies, histologic analysis has revealed periodontal regeneration with areas of ankylosis. Contrary to these findings, BMP-7 augmentation resulted in a significant increase in periodontal regeneration without any ankylosis; so most of the recent research utilizing recombinant human BMP-7 has been involved in the preparation of implant site for ossteointeration.…”