Influence of sodium butyrate on HeLa cell morphology and proliferation

Gálfi, P.; Neogrády, S.; Kutas, F.; Veresegyházy, T.

doi:10.1016/0024-3205(85)90016-5

Cited by 12 publications

(7 citation statements)

References 36 publications

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“…The molecular basis of n-butyric acid action is largely unknown. It has been implicated in a diversity of cellular events, including histone acetylation [3 11, cytoskeleton rearrangements [32,33], protein synthesis [34-361, DNA methylation [37], and gene activation [3842]. It seems that NaB also may provide a method for investigating the process of differentiation and antigen expression in pancreatic cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Modification of antigen expression in human and hamster pancreatic cancer cell lines induced by sodium butyrate

Corrà

Kazakoff

Mogaki

et al. 1993

Teratog Carcinog Mutagen

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The effects of sodium butyrate (NaB) on the growth, morphology, and expression of blood group A, Lewis(a), and CA 19-9 antigen in the hamster pancreatic cancer cell lines, PC-1 (well differentiated) and PC-1.0 (poorly differentiated), and of blood group A, DU-PAN-2, and CA 19-9 antigens in four human pancreatic cancer cell lines, HPAF and CD11 (well differentiated) and CD18 and PANC-1 (poorly differentiated), were examined. NaB inhibited the growth of all cell lines and induced cell enlargement, an increase in secretory material, microfilaments, and pseudopodia. NaB stimulated the production of blood group A antigen in PC-1.0 cells dose dependently, but no change in the expression of this antigen was observed in the human cell lines. However, NaB treatment increased the presence of cells positive for CA 19-9 in PANC-1 but not in the remaining cell lines, none of which reacted with the anti-CA 19-9 antibody before or after NaB treatment. Untreated PANC-1 cells did not produce either blood group A or DU-PAN-2 antigen, but expressed these antigens after NaB treatment in a dose-dependent manner. The results suggest that NaB stimulates the differentiation of the hamster and human pancreatic cancer cell lines and increases or induces the expression of some tumor-associated antigens.

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Section: Discussionmentioning

confidence: 99%

Modification of antigen expression in human and hamster pancreatic cancer cell lines induced by sodium butyrate

Corrà

Kazakoff

Mogaki

et al. 1993

Teratog Carcinog Mutagen

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“…The effects of SFCA on cell populations have been attributed to differentiation, followed by apoptosis in some cell types 55,56 . Investigators have clearly shown that SCFA including butyrate and propionate mediate the inhibition of fibroblast, keratinocyte and endothelial cell proliferation at concentrations of 1 mM and below 57–60 . The SCFA, therefore, are clearly capable of impairing all the principal cell populations involved in reestablishing the structure of the skin in response to injury.…”

Section: Cellular Migration and Proliferationmentioning

confidence: 99%

“…To date, no study has considered the direct effects of SCFA on fibroblast migration, which is surprising because wound repopulation by fibroblasts is a critical stage of wound healing. In addition to SCFA effects on fibroblasts, Galfi et al 57 . demonstrated decreased proliferation along with increased differentiation in keratinoyctes, as witnessed by the modulation of prekeratin molecules and intracellular filament bundles.…”

Section: Cellular Migration and Proliferationmentioning

confidence: 99%

“…Similar to the way individual cell populations exhibit phenotypic variation in response to a wounding stimulus, 75 cellular responses to bacterial metabolites are tissue‐specific. Although some researchers have observed inhibition of epithelial cell proliferation and/or migration, 57,58 , 76 Wilson and Gibson 77 have shown that SCFA stimulate migration of epithelial cells of colonic origin in a dose‐dependent manner. Other studies have shown SCFA‐mediated stimulation of proliferation of gut epithelial cells 78,79 .…”

Section: Differential Cellular Responses To Gpac In Other Tissuesmentioning

confidence: 99%

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Potential role of anaerobic cocci in impaired human wound healing

Wall

Davies

Hill

et al. 2002

Wound Repair Regeneration

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Although more than 80% of infected and 70% of noninfected leg ulcers have been shown to harbor anaerobic organisms, their role in mediating impaired wound healing in the skin is frequently overlooked. There is now increasing evidence that the gram-positive anaerobic cocci play a role (both directly and indirectly) in mediating impaired wound healing in vivo. This article discusses the mechanisms by which these microorganisms may interfere with the inflammation, repair, and remodeling phases of the wound healing process.

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“…Besides its role as the major energy source for the colonocyte [2], there is increasing evidence that butyrate also acts as a critical factor in the physiological turnover of the colonic epithelium [3]. Roles for butyrate have been established for cell proliferation [4], differentiation [5], morphology [6], motility [7], as well as induction of cell cycle arrest [8] and apoptosis [9]. Therefore butyrate may be considered as a chemopreventive agent in colorectal cancer [10,11].…”

Section: Introductionmentioning

confidence: 99%