Influence of Soy Aglycon Isoflavones on Bone-Related Traits and Lens Protein Characteristics of Ovariectomized Rats and Bioactivity Performance of Osteoprogenitor Cells

Lien, Tu-Fa; Chen, Wenlung; Hsu, Yu-Lin; Chen, Hsiu-Ling; Chiou, Robin Y.‐Y.

doi:10.1021/jf061108m

Cited by 5 publications

(7 citation statements)

References 35 publications

(36 reference statements)

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“…The in vitro study with osteoprogenitor cells revealed that cell viability, alkaline phosphatase activity, osteocalcin, and Ca contents of the SAI-supplemented group were higher than those of the unsupplemented group. 39 In the fermented milks, daidzein is the most abundant isoflavone, and it can be further metabolized to equol, a compound with greater estrogenic activity than other isoflavones. The combination of purified daidzein and high Ca in OVX mice favorably protected against the loss of femur and vertebrae BMD and biomechanical strength at multiple skeletal sites.…”

Section: ' Discussionmentioning

confidence: 99%

“…Osteopenia increases with bone turnover rate and with resorption exceeding formation . Influence of soy aglycon isoflavones (SAI) on bone-related traits and lens protein characteristics of ovariectomized rats and bioactivity performance of osteoprogenitor cells were investigated by Lien et al This in vivo study indicated that daily body weight gains in the OVX and OVX + SAI groups were greater than that of the SHAM group. Bone ash and Ca contents of the SHAM and OVX + SAI groups were higher than those of the OVX group.…”

Section: Discussionmentioning

confidence: 99%

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Antiosteoporotic Effects of Lactobacillus-Fermented Soy Skim Milk on Bone Mineral Density and the Microstructure of Femoral Bone in Ovariectomized Mice

Chiang

Pan

2011

J. Agric. Food Chem.

120

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Osteoporosis is a major skeletal disease associated with loss of estrogen in postmenopausal women. In this study, Lactobacillus paracasei subsp. paracasei NTU 101 (NTU 101F) and Lactobacillus plantarum NTU 102 (NTU 102F) were used as starters to ferment soy skim milk. This was then used as a nutritional supplement for 8 weeks to ovariectomized (OVX) mice. This study reveals that soy skim milk fermented with lactobacilli can increase the contents of aglycone isoflavones, soluble calcium, and vitamin D(3). The trabecular bone volumes and trabecular number of the distal femur in mice fed NTU 101F increased by a factor of 1.48 and 1.74 compared with the OVX group. The bone network density and thickness of the distal metaphyseal trabecular in mice fed NTU 101F and Fosamax was significantly greater than that of OVX mice. These results suggest that fermented soy skim milk can attenuate bone loss in OVX mice and lower the risk of osteoporosis.

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Section: ' Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antiosteoporotic Effects of Lactobacillus-Fermented Soy Skim Milk on Bone Mineral Density and the Microstructure of Femoral Bone in Ovariectomized Mice

Chiang

Pan

2011

J. Agric. Food Chem.

120

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“…37,38 In contrary to estrogen, which mediates osteoclasts to release calcium from bone, Lien et al reported that bone ash and calcium contents were higher in SI-treated OVX rats. 39 The in vitro study conducted by the same group found that SI-treated osteoprogenitor cells had a higher viability, ALP activity, OC, and calcium content. 39 It has also been shown that GEN can decrease bone turnover by stimulation of cadmium (Cd) excretion while inhibiting calcium excretion from bone in Cd/OVX rats.…”

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confidence: 99%

“…39 The in vitro study conducted by the same group found that SI-treated osteoprogenitor cells had a higher viability, ALP activity, OC, and calcium content. 39 It has also been shown that GEN can decrease bone turnover by stimulation of cadmium (Cd) excretion while inhibiting calcium excretion from bone in Cd/OVX rats. 40 Interestingly, there exists different dose responses between calcium concentration and a gradual increased dose of supplementary equol (a metabolite of SI) in OVX rats.…”

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confidence: 99%

Soy Isoflavones and Osteoporotic Bone Loss: A Review with an Emphasis on Modulation of Bone Remodeling

Zheng

Lee

Chun

2016

Journal of Medicinal Food

130

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Osteoporosis is an age-related disorder that affects both women and men, although estrogen deficiency induced by menopause accelerates bone loss in older women. As the demographic shifts to a more aged population, a growing number of men and women will be afflicted with osteoporosis. Since the current drug therapies available have multiple side effects, including increased risk of developing certain types of cancer or complications, a search for potential nonpharmacologic alternative therapies for osteoporosis is of prime interest. Soy isoflavones (SI) have demonstrated potential bone-specific effects in a number of studies. This article provides a systematic review of studies on osteoporotic bone loss in relation to SI intake from diet or supplements to comprehensively explain how SI affect the modulation of bone remodeling. Evidence from epidemiologic studies supports that dietary SI attenuate menopause-induced osteoporotic bone loss by decreasing bone resorption and stimulating bone formation. Other studies have also illustrated that bone site-specific trophic and synergistic effects combined with exercise intervention might contribute to improve the bioavailability of SI or strengthen the bonespecific effects. To date, however, the effects of dietary SI on osteoporotic bone loss remain inconclusive, and study results vary from study to study. The current review will discuss the potential factors that result in the conflicting outcomes of these studies, including dosages, intervention materials, study duration, race, and genetic differences. Further well-designed studies are needed to fully understand the underlying mechanism and evaluate the effects of SI on osteoporosis in humans.

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“…Mathey et al 28) reported that isoflavone aglycone administration improved bone mineral density in OVX rats. Lien et al 29) reported that dietary ingestion of aglycone had a favorable effect on bone mineral contents in OVX rats. In addition, Kawakami et al 30) compared the effects of aglycone and glycoside on lipid metabolism in rats and suggested the superiority of aglycone.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Intake of Isoflavone Aglycone-rich Fermented Soybeans on Bone Metabolism in Ovariectomized Rats

Okabe

Tanimoto

2008

JOURNAL OF HEALTH SCIENCE

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We compared the effect of dietary intake of isoflavone aglycone-rich fermented soybeans (FS) with that of glucoside-rich non-fermented soybeans (NFS) on bone metabolism, using ovariectomized (OVX) rats. Female Sprague-Dawley rats were given OVX or a sham operation at 8 weeks of age. After a 2-week recovery, shamoperated rats were given a NFS diet for 57 days, while OVX rats were given the NFS or FS diet (Sham-NFS, OVX-NFS, and OVX-FS group, n = 10). The two diets had the same level of total isoflavone (228 µmol/100 g). The percentage of isoflavone aglycone to total isoflavone was 100% in the FS diet, and approximately 5% in the NFS diet. Tibial bone calcium and phosphorus contents were significantly lower in the OVX-NFS group than in the Sham-NFS group. This reduction was significantly prevented in the OVX-FS group. Tibial trabecular bone density was also significantly reduced by OVX, but the reduction tended to be prevented in the OVX-FS group (p = 0.1). The level of urinary deoxypyridinoline (DPD), a bone resorption marker, was significantly increased by OVX; this increase was significantly prevented in the OVX-FS group. Moreover, urinary total isoflavone levels tended to be higher in the OVX-FS group than in the OVX-NFS group (p = 0.1). In conclusion, this study suggested that intake of FS prevented excessive bone resorption and bone loss following OVX in rats. It was also suggested that these beneficial effects on bone resulted from higher absorption of isoflavone aglycone.

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Influence of Soy Aglycon Isoflavones on Bone-Related Traits and Lens Protein Characteristics of Ovariectomized Rats and Bioactivity Performance of Osteoprogenitor Cells

Cited by 5 publications

References 35 publications

Antiosteoporotic Effects of Lactobacillus-Fermented Soy Skim Milk on Bone Mineral Density and the Microstructure of Femoral Bone in Ovariectomized Mice

Antiosteoporotic Effects of Lactobacillus-Fermented Soy Skim Milk on Bone Mineral Density and the Microstructure of Femoral Bone in Ovariectomized Mice

Soy Isoflavones and Osteoporotic Bone Loss: A Review with an Emphasis on Modulation of Bone Remodeling

Effects of Dietary Intake of Isoflavone Aglycone-rich Fermented Soybeans on Bone Metabolism in Ovariectomized Rats

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