Influence of Subcutaneous Deposits of Melatonin on the Antigonadotrophic Effects of Blinding and Anosmia in Male Rats

Chen, H. J.; Reíter, Russel J.

doi:10.1159/000122994

Cited by 17 publications

(9 citation statements)

References 12 publications

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“…Olfactory bulbectomy combined with blinding decreases blood and pituitary levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) [3,7,23,29,30]. For the most part the effects on FSH and LH, but not on PRL are reversed by pinealectomy [7,23,29,30] which also prevents the main effects of bulbectomy on the reproductive system of blind rats [4,7,23].…”

Section: Discussionmentioning

confidence: 99%

“…For the most part the effects on FSH and LH, but not on PRL are reversed by pinealectomy [7,23,29,30] which also prevents the main effects of bulbectomy on the reproductive system of blind rats [4,7,23]. Thus, factors other than PRL [1] must in part mediate the antigonadal re sponse observed in bulbectomized-blind rats.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, factors other than PRL [1] must in part mediate the antigonadal re sponse observed in bulbectomized-blind rats. Bulbectom ized rats treated with melatonin have decreased blood and pituitary levels of LH and PRL [4,7]; melatonin could also decrease FSH and growth hormone (GH) [22,27,32]. The concurrent reduction of these hormones could be re sponsible for the suppression of the reproductive system.…”

Section: Discussionmentioning

confidence: 99%

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Photoperiodic Control of Reproduction in Olfactory-Bulbectomized Rats

Nelson¹,

Zucker²

1981

Neuroendocrinology

101

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30-day-old male rats were (1) sham-operated or subjected to (2) removal of the olfactory bulbs, (3) olfactory bulbectomy and blinding, (4) olfactory bulbectomy and pinealectomy or (5) olfactory bulbectomy, blinding and pinealectomy. Animals were exposed from 30 to 110 days of age to long-day (14 h of light per day) or short-day (8 h of light per day) photoperiods. The reproductive system of neurologically-intact rats was not affected by exposure to short days. Nor did bulbectomy affect the reproductive system of rats exposed to long days. However, bulbectomized, short-day rats had significantly lower body weights, reduced testicular and seminal vesicle weights and lower plasma testosterone levels than did bulbectomized, long-day rats. The effects of short-day exposure on bulbectomized rats were prevented by pinealectomy. Short-day exposure and blinding exerted similar effects in bulbectomized rats. The testes of rats from all groups contained elongated spermatids; blinding and short-day treatment had no effect on spermatogenesis. Neither mating behavior nor the number of young sired was influenced by photoperiod in bulbectomized or intact rats. Removal of the olfactory bulbs unmasks photoperiodic responsiveness in rats; the antigonadal effects of short-day exposure are mediated by the pineal gland in bulbectomized rats as in species traditionally designated photoperiodic. The mechanisms by which bulbectomy renders rats responsive to short days are considered.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Photoperiodic Control of Reproduction in Olfactory-Bulbectomized Rats

Nelson¹,

Zucker²

1981

Neuroendocrinology

101

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“…The mechanism that induces suppression of testicular function in the old hamster is unknown. Since prolactin concentrations did not differ between young and old hamsters, it appears that the decrease in testicular weight in the aged hamsters may not be due to a decrease in prolactin, despite its documented role in maintenance of testicular weight in hamsters [1,5]. The decrease in LH con centrations, although not significant because of relatively large standard errors, may be partially responsible for the decrease in testicular weight.…”

Section: Discussionmentioning

confidence: 81%

Spontaneous and Melatonin-Induced Testicular Regression in Male Golden Hamsters: Augmented Sensitivity of the Old Male to Melatonin Inhibition

Chen¹

1981

Neuroendocrinology

Self Cite

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Effects of aging and melatonin on testicular function of golden male hamsters were investigated. Young (3–4 months) and old (22–26 months) male hamsters were maintained on a long photoperiod (14 h light, 10 h dark) and injected with graded doses of 10, 25, 50 µg melatonin or injection vehicle, at 17:00 h (3 h before lights off) for a period of 6 weeks. Old male hamsters had significantly decreased testicular weights as compared with the young counterparts, but accessory sex organ (seminal vesicles and accessory glands) weights did not differ between young and old male hamsters. All doses of melatonin suppressed testicular and accessory sex organ weights in the young as well as in the old animals. The percent decrease in testicular weight in response to melatonin treatment was significantly greater (p < 0.01) in the old than in the young hamsters. Basal plasma prolactin concentration did not differ between young and old male hamsters. Melatonin significantly decreased plasma prolactin concentrations in both age-groups. Young hamsters had greater mean plasma luteinizing hormone concentrations than old hamsters, and melatonin suppressed luteinizing hormone equally in both groups. These results indicate that the testes of the male hamster spontaneously regress during the aging process, and this may be independent of prolactin, since there was no difference in serum prolactin concentrations between young and old hamsters. The finding that melatonin injections brought about a greater percent decrease in testicular weight in the old than in the young hamsters suggests that there is an increased sensitivity of the reproductive system to melatonin inhibition in the old male hamster.

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“…Blinding of an adult rat has no influence on its reproductive condition ; blinding of a young rat produces a slight, but signifi¬ cant, retardation of its reproductive development. Rats that are both blind and anosmic exhibit a dramatic gonadal regression or inhibition of development, in adults and young, respectively; pinealectomy completely reverses this gonadal inhibition (Reiter, Klein & Donofrio, 1969;Reiter et al, 1971 ;Chen & Reiter, 1980). Perhaps in the rat, as well as in the deer mouse, both photic and social olfactory cues regulate reproduction, although greater experimental contrivance is required to see their joint influence in the rat.…”

Section: Methodsmentioning

confidence: 99%

Influence of melatonin on pubertal development in male deer mice (Peromyscus maniculatus)

Whitsett¹,

Underwood²,

Cherry³

1984

Reproduction

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Summary. The role of melatonin in pubertal development was assessed in male deer mice (Peromyscus maniculatus bairdii) exposed to photoperiodic and social stimuli. Exogenous melatonin retarded puberty in males reared in a long photoperiod, but was without effect in males reared in short days. Melatonin did not retard pubertal development induced by exposure of short-day males to an adult female. These results suggest that pineal melatonin mediates photoperiodic, but not social, control of pubertal development.

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Influence of Subcutaneous Deposits of Melatonin on the Antigonadotrophic Effects of Blinding and Anosmia in Male Rats

Cited by 17 publications

References 12 publications

Photoperiodic Control of Reproduction in Olfactory-Bulbectomized Rats

Photoperiodic Control of Reproduction in Olfactory-Bulbectomized Rats

Spontaneous and Melatonin-Induced Testicular Regression in Male Golden Hamsters: Augmented Sensitivity of the Old Male to Melatonin Inhibition

Influence of melatonin on pubertal development in male deer mice (Peromyscus maniculatus)

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