Influence of surgically induced varicocele on testicular blood flow, temperature, and histology in adult rats and dogs.

Saypol, David C.; Howards, Stuart S.; Turner, Terry T.; Miller, Edward D.

doi:10.1172/jci110252

Cited by 245 publications

(151 citation statements)

References 23 publications

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…The rat is a good model for varicocele induction as the insertion of its left spermatic vein in the left renal vein is positioned at a 90° angle, which is anatomically similar to humans. In consequence, a partial ligature of the left renal vein can be surgically performed, inducing an increase in the venous pressure, resulting in the venous reflux into the left vein; this is further reflected in the pampiniform plexus, simulating what happens in teenager patients with varicocele (Saypol et al 1981, Turner 2001, Zhang et al 2008. As the sprouting of varicocele usually coincides with the onset of puberty (Skoog et al 1997), due to the physical growth and the increase in abdominal pressure (Delaney 2004), and as such effect can produce progressive complications on the fertility (Bong & Koo 2004), we induced varicocele in rats at peripuberty and studied the reproductive parameters at adulthood.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol improves reproductive parameters of adult rats varicocelized in peripuberty

Mendes¹,

Paccola²,

Neves³

et al. 2016

Reproduction

View full text Add to dashboard Cite

The aim of this study was to investigate the protective action of resveratrol against the reproductive damage caused by left-sided experimental varicocele. There was a reduction of testicular major axis in the varicocele group when compared with the other groups; the testicular volume was reduced in varicocele group in comparison to the sham-control and resveratrol groups. The frequency of morphologically abnormal sperm was higher in varicocele and varicocele treated with resveratrol groups than in sham-control and resveratrol groups. The frequency of sperm with 100% of mitochondrial activity and normal acrosome integrity were lower in varicocele group than in varicocele treated with resveratrol, sham-control and resveratrol groups. Sperm motility was also reduced in varicocele group than in other groups. The sperm DNA fragmentation was higher in varicocele group than in other groups.

show abstract

Section: Introductionmentioning

confidence: 99%

Resveratrol improves reproductive parameters of adult rats varicocelized in peripuberty

Mendes¹,

Paccola²,

Neves³

et al. 2016

Reproduction

View full text Add to dashboard Cite

show abstract

“…Our study did not reveal any significant difference in the serum basal testosterone concentration between varicocelized and intact animals. This however does not indicate an absence of difference in Leydig cell secretory function between the two groups since delicate alterations in Leydig cell secretory function may not be accompanied by alterations in peripheral serum androgen levels (Saypol et al, 1981).…”

Section: Discussionmentioning

confidence: 85%

The Ameriorating Effects of Grapefruit Seed Extract on Testicular Morphology and Function of Varicocelized Rats

et al. 2008

View full text Add to dashboard Cite

SUMMARY:Varicoceles are abnormal tortuosity and dilatation of the veins of the pampiniform plexus that drain the testis.The pathophysiology of testicular damage in varicocele has not been completely understood. However there is an increasing body of evidence pointing towards the role of reactive oxygen species and oxidative stress in the pathogenesis of varicocele related subfertility. In the present study we examined the role of proanthocynidin-rich ethanol extract of grapefruit seed as an antioxidant in protecting the testis against damage in experimental varicocele. Three groups of rats were constructed as the first group had intact rats; experimental bilateral varicoceles were established by complete ligation of the left and right main spermatic veins in the later two groups. The third group had in addition daily gavage administration of 10mg/ kg body weight ethanol extract of grapefruit seed. Eight weeks after varicocele induction, bilateral testicular weights, bilateral testicular volumes, bilateral caudal epididymal sperm characteristics, and bilateral testicular histology and serum hormone levels were tested. It was found that the testes of grapefruit seed extract treated animals had better functional and histological profiles compared to the untreated varicocelized animals. These results indicated the effectiveness of grapefruit seed extract for preservation of testes function morphology in varicocelized subjects.

show abstract

“…and Rodgers and Rowland4 are listed in Table 2 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40…”

Section: Resultsmentioning

confidence: 99%

Development of Physiologically Based Organ Models to Evaluate the Pharmacokinetics of Drugs in the Testes and the Thyroid Gland

Pilari

Gaub

Block

et al. 2017

CPT Pharmacometrics Syst. Pharmacol.

View full text Add to dashboard Cite

We extended a generic whole‐body physiologically based pharmacokinetic (PBPK) model for rats and humans for organs of the reproductive and endocrine systems (i.e., the testes and the thyroid gland). An extensive literature search was performed, first, to determine the most generic organ model structures for testes and thyroid across species, and, second, to identify the corresponding anatomic and physiological parameters in rats and humans. The testes and thyroid organ models were implemented in the PBPK modeling software PK‐Sim and MoBi. The capability of the PBPK approach to simulate the testes and thyroid tissue concentration data was demonstrated using a series of test compounds. The presented organ model structures and parameterization yielded a close agreement between observed and simulated tissue concentrations over time. The organ models are ready to be used to predict the pharmacokinetics of passively entering drugs in the testes and thyroid tissue in a generic PBPK modeling framework.

show abstract

Influence of surgically induced varicocele on testicular blood flow, temperature, and histology in adult rats and dogs.

Cited by 245 publications

References 23 publications

Resveratrol improves reproductive parameters of adult rats varicocelized in peripuberty

Resveratrol improves reproductive parameters of adult rats varicocelized in peripuberty

The Ameriorating Effects of Grapefruit Seed Extract on Testicular Morphology and Function of Varicocelized Rats

Development of Physiologically Based Organ Models to Evaluate the Pharmacokinetics of Drugs in the Testes and the Thyroid Gland

Contact Info

Product

Resources

About