Influence of the BDNF Val66Met polymorphism on coping response to stress in patients with advanced gastric cancer

Koh, Min Jung; Jeung, Hei Cheul; Namkoong, Kee; Chung, Hyun Cheol; Kang, Jee In

doi:10.1016/j.jpsychores.2014.04.008

Cited by 17 publications

(19 citation statements)

References 37 publications

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“…Nevertheless, anxiety and fatigue levels have been adjusted for in our analysis. Although we did not observe any significant associations in this study, other genetic association studies have also shown that unlike subjective CRCI, anxiety, fatigue, and depression are not ameliorated but worsened among BDNF Met carriers [34, 35]. Considering the combination of these facts, we are confident that our observations are due to true associations of BDNF Val66Met polymorphism with reduced odds of subjective cognitive decline rather than the confounding effects of fatigue or other psychosocial factors.…”

Section: Discussioncontrasting

confidence: 64%

Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy

et al. 2018

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Cancer-related cognitive impairment (CRCI) adversely affects cancer patients. We had previously demonstrated that the BDNF Val66Met genetic polymorphism is associated with lower odds of subjective CRCI in the multitasking and verbal ability domains among breast cancer patients receiving chemotherapy. To further assess our previous findings, we evaluated the association of BDNF Val66Met polymorphism with subjective and objective CRCI in a temporally separate cohort of patients and pooled findings from both the original ( n = 145) and current ( n = 193) cohorts in a meta-analysis. Subjective CRCI was assessed using FACT-Cog. Objective CRCI was evaluated using computerized neuropsychological tests. Genotyping was carried out using Sanger sequencing. The association of BDNF Val66Met genotypes and CRCI was examined with logistic regression. A fixed-effect meta-analysis was conducted using the inverse variance method. In the meta-analysis ( n = 338), significantly lower odds of CRCI were associated with Met allele carriers based on the global FACT-Cog score (OR = 0.52, 95% CI 0.29–0.94). Furthermore, Met allele carriers were at lower odds of developing impairment in the domains of memory (OR = 0.34, 95% CI: 0.17–0.70), multitasking (OR = 0.33, 95% CI: 0.18–0.59), and verbal ability (OR = 0.46, 95% CI: 0.24–0.88). Consistent with the previous study, lower odds of subjective CRCI among patients with the BDNF Met allele was observed after adjusting for potential confounders in the multitasking (OR = 0.30, 95% CI: 0.14–0.67) domain. In conclusion, carriers of the BDNF Met allele were protected against global subjective CRCI, particularly in the domains of memory, multitasking, and verbal ability. Our findings further contribute to the understanding of CRCI pathophysiology. Electronic supplementary material The online version of this article (10.1007/s12035-018-1410-4) contains supplementary material, which is available to authorized users.

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Section: Discussioncontrasting

confidence: 64%

Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy

et al. 2018

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“…Third, studies have shown that patients with gastric cancer exhibit higher levels of mixed depression and anxiety symptoms compared to those with other types of cancer, raising the question of whether gastric cancer is associated with more biological mechanisms of depression, such as cytokine release [23]. Consistent with this biological hypothesis, Koh et al investigated the association between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and stress coping response in patients diagnosed with gastric cancer and found that the BDNF Val66Met polymorphism may be involved in individual coping responses to cancer [24]. …”

Section: Discussionmentioning

confidence: 99%

Depressive disorders among patients with gastric cancer in Taiwan: a nationwide population-based study

Liu

Yeh

et al. 2018

BMC Psychiatry

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BackgroundIn cancer patients, depressive disorder comorbidity is associated with greater suicide risk and poorer treatment outcomes, quality of life, and adherence to treatment. The aim of the study was to evaluate the incidence of newly-diagnosed depressive disorders after a gastric cancer diagnosis compared with a matched cohort using the National Health Insurance Research Database in Taiwan.MethodsWe conducted a retrospective cohort study of 57,506 patients (28,753 patients with gastric cancer and 28,753 matched patients) selected from the National Health Insurance Research Database. Patients were observed for a maximum of 12 years to determine the incidence of newly-diagnosed depressive disorders. Also, a Cox regression analysis which included death as an independent censor was performed to identify the potentially predictive variables for developing subsequent depressive disorders following a cancer diagnosis among the patients suffering from gastric cancer.ResultsThe cumulative incidence of depressive disorders in the gastric cancer patients was significantly higher compared to those in the matched cohort (p < .001). The adjusted hazard ratio was 1.54 (95% confidence interval, CI = 1.39–1.70, P < .001) in the gastric cancer cohort compared with the matched cohort. Independent predictive variables for developing subsequent depressive disorders among the patients with gastric cancer included female sex and hypertension.ConclusionsIn the study, higher incidence of new-onset depression, being defined by the records of the diagnostic codes combining antidepressants use in a nationwide database, was noted in the gastric cancer patients compared with the matched cohort. In addition, female sex and comorbid hypertension may be predictive variables for the subsequent depression among the patients with gastric cancer. Further clinical prospective studies were necessary to confirm these findings.

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“…Interestingly, some beneficial effects of exercise appear to be mediated by an upregulation of BDNF in the brain, as well as an enhancement of mBDNF and a reduction of proBDNF [13]. In addition, CRF and related symptoms in human subjects have been associated not only with lower serum/plasma levels of BDNF [14,15], but also a single-nucleotide polymorphism of the BDNF gene [16,17]. Based on the literature, fatigue and BDNF may form a feedback loop: fatigue and its consequential decrease in voluntary activity may alter BDNF levels, and BDNF levels may also affect fatigue symptoms.…”

Section: Introductionmentioning

confidence: 99%

Induction of fatigue-like behavior by pelvic irradiation of male mice alters cognitive behaviors and BDNF expression

et al. 2020

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Fatigue and cognitive deficits are often co-occurring symptoms reported by patients after radiation therapy for prostate cancer. In this study, we induced fatigue-like behavior in mice using targeted pelvic irradiation to mimic the clinical treatment regimen and assess cognitive behavioral changes. We observed that pelvic irradiation produced a robust fatigue phenotype, a reduced rate of spontaneous alternation in a Y-maze test, and no behavioral change in an open field test. We found that reversal learning for fatigued mice was slower with respect to time, but not with respect to effort put into the test, suggesting that fatigue may impact the ability or motivation to work at a cognitive task without impairing cognitive capabilities. In addition, we found that mice undergoing pelvic irradiation show lower whole-brain levels of mature BDNF, and that whole-brain proBDNF levels also correlate with spontaneous alternation in a Y-maze test. These results suggest that changes in BDNF levels could be both a cause and an effect of fatigue-related changes in behavior.

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Influence of the BDNF Val66Met polymorphism on coping response to stress in patients with advanced gastric cancer

Cited by 17 publications

References 37 publications

Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy

Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy

Depressive disorders among patients with gastric cancer in Taiwan: a nationwide population-based study

Induction of fatigue-like behavior by pelvic irradiation of male mice alters cognitive behaviors and BDNF expression

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