2007
DOI: 10.1007/s00251-007-0255-1
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Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility

Abstract: The great amount of nitric oxide (NO) produced by the inducible isoform of NO synthase (iNOS) exerts deleterious effects, and iNOS expression is raised in the colonic mucosa of inflammatory bowel disease (IBD) patients. This is the first association analysis of polymorphisms within the NOS2A extended gene with IBD susceptibility. We analyzed 336 patients of Crohn's disease (CD), 355 of ulcerative colitis (UC), and 536 healthy controls from a Spanish population. We tested a (CCTTT)n microsatellite, a (-/TAAA) i… Show more

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Cited by 51 publications
(40 citation statements)
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“…IBD have been found to be associated with an overproduction of nitric oxide (NO) by the inducible isoform of NO synthase (iNOS) [75]. Increased luminal and salivary NO have also been detected in IBD patients [59,76,77].…”
Section: Effects On Nitric Oxide and Inducible Isoform Of Nitric Oxidmentioning
confidence: 99%
“…IBD have been found to be associated with an overproduction of nitric oxide (NO) by the inducible isoform of NO synthase (iNOS) [75]. Increased luminal and salivary NO have also been detected in IBD patients [59,76,77].…”
Section: Effects On Nitric Oxide and Inducible Isoform Of Nitric Oxidmentioning
confidence: 99%
“…Variations in promoter region of NOS2A have been proposed of critical importance in genetic association studies of diseases, such as severe malaria [37], rheumatoid arthritis [38], Parkinson's disease [39], inflammatory bowel disease [40] etc. These variations have collectively shown their potential in differential expression of NOS2A.…”
Section: Discussionmentioning
confidence: 99%
“…Specific oral immunotherapy using IFN-γ may induce tolerance induction in previous reports, the absence of functional inducible nitric oxide synthase (iNOS) enhanced the efficacy of oral tolerance [45] . Conversely, nitric oxide (NO) and iNOS production were increased both in colonic tissues collected from IBD patients and in a DSS-induced colitis model [46,47] . These data suggest that dysfunctional oral tolerance in IBD patients might be due to NO induction in addition to inflammation.…”
Section: Cd19mentioning
confidence: 99%