NOS2A promoter (CCTTT)n association with TB lacks independent functional correlation amongst Indians

Jena, Mamata; Srivastava, Amit; Singh, Rajnish Kumar; Sharma, Preeti; Das, Parimal; Bamezai, R.

doi:10.1016/j.tube.2013.10.004

Cited by 2 publications

(2 citation statements)

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“…reported that haplotypes composed of two SNP loci in the NOS2A gene promoter, rs9282799 and rs8078340, are significantly associated with TB in South Africans [ 22 ]. In addition, the NOS2A gene promoter region (CCTTT) has a significant protective effect against TB in various Indian populations [ 34 ]. A study African Americans found that multiple SNPs in the NOS2A gene were associated with TB, and some sites were also found to have synergistic effects on the TLR4 and IFNGR1 genes and affect TB risk [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

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Association of NOS2A gene polymorphisms with susceptibility to bovine tuberculosis in Chinese Holstein cattle

et al. 2021

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Bovine tuberculosis (bTB) is a global zoonotic disease that has detrimental economic impacts worldwide. The NOS2A gene plays a key role in immunological control of many infectious diseases. However, research on the association between NOS2A polymorphisms and bTB infection in Holstein cattle reared on the Yunnan-Guizhou plateau of China is scarce. This study investigated a possible linkage between NOS2A polymorphisms and risk of developing bTB in Chinese Holstein cattle. The NOS2A gene was genotyped in 144 bTB-infected Holstein cows and 139 healthy controls were genotyped through nucleotide sequencing. Ten single-nucleotide polymorphisms (SNPs) were detected, six of which were associated with susceptibility/resistance patterns of bTB. Furthermore, the C/T genotypes of 671 and 2793, and T/T genotype of E22 (+15) were significantly associated with susceptibility risk; the G/A genotype of 2857, T/T genotype of E9 (+65), and C/C genotype of E9 (+114) probably increased resistance to bTB. In addition, the haplotypes of NOS2A-2 and NOS2A-9 were risk factors for bTB susceptibility, while the NOS2A-5 and NOS2A-8 haplotypes were contributing protective variants against tuberculosis. There is a significant association between variation in SNPs of NOS2A and tuberculosis susceptibility/resistance pattern. These findings suggest that substitution of genetic selection would be helpful for eradicating bTB. However, further investigation is required to study the underlying mechanism through which NOS2A polymorphisms affect bTB infection.

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Section: Discussionmentioning

confidence: 99%

“…In addition, the NOS2A gene promoter region (CCTTT) has a significant protective effect against TB in various Indian populations [34]. A study African Americans found that multiple SNPs in the NOS2A gene were associated with TB, and some sites were also found to have synergistic effects on the TLR4 and IFNGR1 genes and affect TB risk [15].…”

Section: Discussionmentioning

confidence: 99%

Association of NOS2A gene polymorphisms with susceptibility to bovine tuberculosis in Chinese Holstein cattle

et al. 2021

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The landscape of different molecular modules in an immune microenvironment during tuberculosis infection

Zhang

Luo

Huang

et al. 2021

Briefings in Bioinformatics

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Tuberculosis is a chronic inflammatory disease caused by Mycobacterium tuberculosis. When tuberculosis invades the human body, innate immunity is the first line of defense. However, how the innate immune microenvironment responds remains unclear. In this research, we studied the function of each type of cell and explained the principle of an immune microenvironment. Based on the differences in the innate immune microenvironment, we modularized the analysis of the response of five immune cells and two structural cells. The results showed that in the innate immune stress response, the genes CXCL3, PTGS2 and TNFAIP6 regulated by the nuclear factor kappa B(NK-KB) pathway played a crucial role in fighting against tuberculosis. Based on the active pathway algorithm, each immune cell showed metabolic heterogeneity. Besides, after tuberculosis infection, structural cells showed a chemotactic immunity effect based on the co-expression immunoregulatory module.

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NOS2A promoter (CCTTT)n association with TB lacks independent functional correlation amongst Indians

Cited by 2 publications

References 39 publications

Association of NOS2A gene polymorphisms with susceptibility to bovine tuberculosis in Chinese Holstein cattle

Association of NOS2A gene polymorphisms with susceptibility to bovine tuberculosis in Chinese Holstein cattle

The landscape of different molecular modules in an immune microenvironment during tuberculosis infection

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