Influence of the Lipophilic External Phase Composition on the Preparation and Characterization of Xylan Microcapsules—A Technical Note

Nagashima, Toshiyuki; Oliveira, Elquio Eleamen; Silva, Acarilia Eduardo da; Marcelino, Henrique Rodrigues; Gomes, Monique Christine Salgado; Aguiar, Larissa Muratori; Araújo, Ivonete Batista de; Soares, Luiz Alberto Lira; Oliveira, Anselmo Gomes de; Egito, Eryvaldo Sócrates Tabosa do

doi:10.1208/s12249-008-9115-z

Cited by 17 publications

(21 citation statements)

References 12 publications

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“…PbMs were produced by the ICL method as previously reported by Nagashima-Junior and colleagues [9]. Briefly, an alkali xylan solution was added into a chloroform:cyclohexane (1:4, v/v) mixture in order to obtain a W/O emulsion and then cross-linked using TC (Figure 1).…”

Section: Microparticle Productionmentioning

confidence: 99%

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Leads from Physical, Chemical, and Thermal Characterization on Cytotoxic Effects of Xylan-Based Microparticles

et al. 2015

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Interfacial cross-linking (ICL) has been considered a feasible technique to produce polysaccharide-based microparticles (PbMs), even though only a few studies have been concerned with their biocompatibility. In this work, PbMs were prepared by the ICL method and characterized in regard to their in vitro biocompatibility, chemical linkages, and physical and thermal properties. First, the cell viability assay revealed that PbMs toxicity was concentration-dependent. Then, it was observed that the toxicity may be related to the way in which the binding occurred, and not exclusively to the stoichiometry between the polymer and the cross-linking agent. Moreover, the PbMs biosafety was predicted by the use of physicochemical procedures, which were able to identify unbound cross-linking agent residues and also to reveal the improvement of their thermal stability. Accordingly, this work suggests a step-by-step physicochemical procedure able to predict potential toxicity from micro-structured devices produced by polysaccharides. Likewise, the use of PbMs as a drug carrier should be cautiously considered.

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Section: Microparticle Productionmentioning

confidence: 99%

“…However, its use as a raw material for the production of drug delivery systems has emerged in the recent literature [7,8]. Our group has also evaluated the production of colon-targeted drug carriers as a promising application for xylan [9,10].…”

Section: Introductionmentioning

confidence: 99%

Leads from Physical, Chemical, and Thermal Characterization on Cytotoxic Effects of Xylan-Based Microparticles

et al. 2015

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“…Different microencapsulation techniques have been used for the production of xylanbased microparticles. Coacervation, interfacial cross-linking polymerization, and spraydrying have been shown to be the most successful methodologies for that purpose (Garcia et al, 2001;Nagashima et al, 2008).…”

Section: Xylanmentioning

confidence: 99%

“…For instance, microparticles have been used in order to achieve controlled release of drugs, deliver two or more agents in the same system, improve the bioavailability and the biodistribution of molecules, target drugs to specific cells or issues, or mask the unpleasant taste of some active molecules (Simó et al, 2003;Tran et al, 2011;Vehring, 2008). Xylan microparticles have been successfully produced by the following methods: coacervation (Garcia et al, 2001), interfacial crosslinking (Nagashima et al, 2008) and spray-drying (Unpublished data), all of which are described in the following subsection.…”

Section: Fig 8 Structural Differences Between Microcapsules and Micmentioning

confidence: 99%

“…The influence of the lipophilic external phase on the production of xylan-based microparticles by interfacial cross-linking polymerization has been investigated (Nagashima et al, 2008). Three different external phases were investigated: a 1:4 (v/v) chloroform:cyclohexane mixture, soybean oil, and a medium chain triglyceride, with viscosities below 1, 24, and 52 cP, respectively.…”

Section: Interfacial Cross-linking Polymerizationmentioning

confidence: 99%

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