Influence of the noradrenergic system on the formation of intrusive memories in women: an experimental approach with a trauma film paradigm

Rombold, Felicitas; Wingenfeld, Katja; Renneberg, Babette; Hellmann-Regen, Julian; Otte, Christian; Röepke, Stefan

doi:10.1017/s0033291716001379

Cited by 29 publications

(19 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Administration of cortisol (20 mg) prior to film viewing in a sample of 60 women also had no effect on the frequency or vividness of intrusive memories ( Rombold et al, 2016 ). However, another study by the same group found that activity of the noradrenergic system prior to film viewing did have an effect on intrusive memories ( Rombold et al, 2016 ). In this study, participants received either 10 mg of yohimbine (which stimulated noradrenergic activity), 0.15 mg of clonidine (which inhibited noradrenergic activity), or placebo, 60 min prior to viewing a distressing film.…”

Section: Insights From Cognitive Science On the Reduction Of Intrusivmentioning

confidence: 99%

Intrusive memories of trauma: A target for research bridging cognitive science and its clinical application

Iyadurai

Visser

Lau‐Zhu

et al. 2019

Clinical Psychology Review

165

115

View full text Add to dashboard Cite

Intrusive memories of a traumatic event can be distressing and disruptive, and comprise a core clinical feature of post-traumatic stress disorder (PTSD). Intrusive memories involve mental imagery-based impressions that intrude into mind involuntarily, and are emotional. Here we consider how recent advances in cognitive science have fueled our understanding of the development and possible treatment of intrusive memories of trauma. We conducted a systematic literature search in PubMed, selecting articles published from 2008 to 2018 that used the terms “trauma” AND (“intrusive memories” OR “involuntary memories”) in their abstract or title. First, we discuss studies that investigated internal (neural, hormonal, psychophysiological, and cognitive) processes that contribute to intrusive memory development. Second, we discuss studies that targeted these processes using behavioural/pharmacological interventions to reduce intrusive memories. Third, we consider possible clinical implications of this work and highlight some emerging research avenues for treatment and prevention, supplemented by new data to examine some unanswered questions. In conclusion, we raise the possibility that intrusive memories comprise an alternative, possibly more focused, target in translational research endeavours, rather than only targeting overall symptoms of disorders such as PTSD. If so, relatively simple approaches could help to address the need for easy-to-deliver, widely-scalable trauma interventions.

show abstract

Section: Insights From Cognitive Science On the Reduction Of Intrusivmentioning

confidence: 99%

Intrusive memories of trauma: A target for research bridging cognitive science and its clinical application

Iyadurai

Visser

Lau‐Zhu

et al. 2019

Clinical Psychology Review

165

115

View full text Add to dashboard Cite

show abstract

“…The limit of detection of free cortisol was 0.2 nM. sAA activity was determined using a modified protocol of a previously published direct alpha-amylase assay (Rombold et al, 2016). Inter-and intra-assay coefficients of variation were both lower than 10% for sAA activity.…”

Section: Laboratory Parametersmentioning

confidence: 99%

Psychophysiological stress response and memory in borderline personality disorder

Duesenberg

Wolf

Metz

et al. 2019

European Journal of Psychotraumatology

View full text Add to dashboard Cite

Background: Previously, we found that patients with borderline personality disorder (BPD) but not healthy controls (HC) showed improved memory retrieval after hydrocortisone administration.Objective: In this study, we examined whether increases in endogenous cortisol after psychosocial stress are associated with memory function in patients with BPD and in healthy individuals.Methods: We recruited 49 female patients with BPD and 49 female HC. All participants were exposed to a psychosocial stressor, the Trier Social Stress Test (TSST) and a control condition (Placebo (P-)TSST) in randomized order. Salivary cortisol, alpha amylase (sAA) and blood pressure were measured in response to stress. Subsequently, we examined free recall of a previously learned word list, autobiographical memory, and working memory.Results: We found a stress*time*group interaction effect for the cortisol response and for sAA to stress, which is mainly triggered by a slightly different increase in cortisol between groups from pre to post TSST. Furthermore, BPD patients showed a less pronounced increase in diastolic blood pressure compared to HC after stress. There was no effect of stress on memory performance in any tests, either in healthy controls or in patients with BPD.Conclusion: Our results suggest a slightly blunted response of the HPA axis and the sympathetic nervous system to stress in BPD compared to healthy women. In contrast to hydrocortisone administration, psychosocial stress did not improve memory retrieval in BPD patients. This might be explained by lower cortisol concentrations and parallel increases in norepinephrine and negative affect after stress.

show abstract

“…There is no study that has used an a 1 -adrenergic receptor antagonists for the prevention of PTSD nor a study that had explored their effects with the trauma film paradigm. However, clonidine, a drug that also inhibits noradrenergic activity, did not lead to less intrusions after an analogue trauma (Rombold et al, 2016). Another pharmacological option to acutely enhance REM sleep would be acetylcholineesterase inhibitors such as galantamine (Biard, Douglass, Robillard, & De Koninck, 2016).…”

Section: Discussion and Ideas For Further Researchmentioning

confidence: 99%

REM sleep in acutely traumatized individuals and interventions for the secondary prevention of post-traumatic stress disorder

Repantis

Wermuth

Tsamitros

et al. 2020

European Journal of Psychotraumatology

View full text Add to dashboard Cite

Influence of the noradrenergic system on the formation of intrusive memories in women: an experimental approach with a trauma film paradigm

Cited by 29 publications

References 57 publications

Intrusive memories of trauma: A target for research bridging cognitive science and its clinical application

Intrusive memories of trauma: A target for research bridging cognitive science and its clinical application

Psychophysiological stress response and memory in borderline personality disorder

REM sleep in acutely traumatized individuals and interventions for the secondary prevention of post-traumatic stress disorder

Contact Info

Product

Resources

About