Influence of the punch diameter and curvature on the yield pressure of MCC-compacts during Heckel analysis

Kiekens, Filip; Debunne, Ann; Vervaet, Chris; Baert, Lieven; Vanhoutte, Filip; Assche, Ivo Van; Menard, F. A.; Remon, Jean Paul

doi:10.1016/j.ejps.2004.02.010

Cited by 18 publications

(5 citation statements)

References 27 publications

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“…The yield pressure value for cellulose I materials such as Prosolv ® SMCC 50 was 93 MPa. This value was close to 89.1 MPa, reported previously (Kiekens et al, 2004). Researchers have reported that a 2% SiO 2 in cellulose I virtually does not affect P y (Habib et al, 1999;Van Veen et al, 2005).…”

Section: Heckel Analysissupporting

confidence: 89%

Assessment of co-processing of cellulose II and silicon dioxide as a platform to enhance excipient functionality

Rojas¹

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This thesis project studied microcrystalline cellulose II (CII), a polymorphic form of cellulose, which has lower mechanical properties, less plastic deformation, higher elastic recovery and faster disintegration properties than microcrystalline cellulose I (CI). Also, the effects of processing and silicification on CII materials were investigated. Particle modification through spray drying, wet granulation and spheronization was employed to improve CII performance. Spray-drying (SDCII) and wet granulation (WGCII) produced materials with no difference in mechanical or disintegration properties from unprocessed CII, but did show an increase in density and particle flow. Conversely, spheronization (SPCII) showed the poorest mechanical properties compared to CII. Further, SDCII showed better dilution potential than CII. Thus the advantages of SDCII were apparent when it was mixed with a poorly compressible drug (acetaminophen) because fibrous CII was converted to spheroidal particles through spray drying. The rapid disintegration of SDCII and CII compacts was due to water wicking through capillaries followed by compact bursting. Compacts of ibuprofen mixed with SDCII and Avicel ® PH-102 had comparable disintegration rates and release profiles compared to ibuprofen formulated with commercial disintegrants and Avicel ® PH-102, especially at levels 10% w/w. Adding fumed silica into CII particles through spray drying, wet granulation (WGCII) and spheronization (SPCII) at 2-20% w/w was also studied. Silicification increased physical properties such as true density, Hausner ratio, porosity, ejection force and specific surface area of SDCII and WGCII. Other properties such as bulk and tap densities were reduced due to the amorphous and light character of fumed silica. Spheronized CII showed no change in these properties with silicification. Silicification diminished lubricant sensitivity with magnesium stearate due to the competition of SiO 2 with magnesium stearate to coat CII particles. Silicification also decreased the affinity of CII for water only at the 20% w/w level due to the few silanol groups available for water interaction compared to surface hydroxyl groups on CII alone. Particle size modification of CII was process-dependent v transformed my vision of the role of pharmaceutics and physical pharmacy for drug development. I also appreciate their financial support and the initial support provided by University of Antioquia, especially to Professors Tobon and Bedoya. I also express my gratitude to Dr. Reist for his trust, support and teaching me the value of professionalism and personalized pedagogy in the Pharmacy Practice Laboratory.

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Section: Heckel Analysissupporting

confidence: 89%

Assessment of co-processing of cellulose II and silicon dioxide as a platform to enhance excipient functionality

Rojas¹

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“…It is denoted as

The slope of the straight line portion, K , is the reciprocal of the mean yield pressure, P y , of the material. From the intercept A , the relative density, D A , can be calculated using the following equation:

Relative density of the powder at the point when the applied pressure equals zero, D 0 , is used to describe the initial rearrangement phase of densification as a result of die filling;

Relative density, D B , describes the phase of rearrangement at low pressures and is the difference between D A and D 0 [ 15 , 16 ].…”

Section: Methodsmentioning

confidence: 99%

Development of Corn Starch-Neusilin UFL2 Conjugate as Tablet Superdisintegrant: Formulation and Evaluation of Fast Disintegrating Tablets

Juneja

Kaur

Odeku

et al. 2014

Journal of Drug Delivery

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In the present study, corn Starch-Neusilin UFL2 conjugates were prepared by physical, chemical, and microwave methods with the aim of using the conjugates as tablet superdisintegrant. Various powder tests, namely, angle of repose, bulk density, tapped density, Hausner's ratio, Carr's index, swelling index, and powder porosity were conducted on the samples. The conjugates were characterized by ATR-FTIR, XRD, DSC, and SEM techniques. Heckel and Kawakita models were applied to carry out compression studies for the prepared conjugates. Fast disintegrating tablets of domperidone were prepared using corn starch and corn Starch-Neusilin UFL2 conjugates as tablet superdisintegrants in different concentrations. Conjugates were found to possess good powder flow and tabletting properties. Heckel analysis indicated that the conjugates prepared by microwave method showed the slowest onset of plastic deformation while Kawakita analysis indicated that the conjugates prepared by microwave method exhibited the highest amount of total plastic deformation. The study revealed that the corn Starch-Neusilin UFL2 conjugates possess improved powder flow properties and could be a promising superdisintegrant for preparing fast disintegrating tablet. Also, the results sugessted that the microwave method was found to be most effective for the preparation of corn Starch-Neusilin UFL2 conjugates.

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“…where, D B is the relative density at low pressures and D 0 is the relative density when no pressure is applied [12,13].…”

Section: Heckel Functionmentioning

confidence: 99%

“…where, C is the degree of volume reduction, V 0 is the initial bulk volume of the powder, V p is the bulk volume under pressure, 'a' is a constant related to minimum porosity of material before compression and 'b' is a constant associated with the plasticity of the material [12,13].…”

Section: Kawakita Functionmentioning

confidence: 99%

Development and Evaluation of MCC-SiO2/CMC-SiO2 Conjugates as Tablet Super-Disintegrants

et al. 2022

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In the present study, microcrystallinecellulose–colloidal silicon dioxide (MCC-SiO2) and carboxymethylcellulose–colloidal silicon dioxide (CMC-SiO2) conjugates have been investigated as superdisintegrants in fast dissolving tablets (FDTs). MCC-SiO2 and CMC-SiO2 conjugates were prepared and micromeritic studies, FTIR, SEM and XRD methods were utilized for characterizing the powdered conjugates. The conjugates were used for the preparation of domperidone FDTs by direct compression and thewetting time, water absorption ratio, disintegration time and in vitro drug release were evaluated. Effective pore radius of MCC-SiO2 and CMC-SiO2 conjugates for 1:1, 1:2.5 and 1:5 was found to be 13.35 ± 0.31 µm, 15.66 ± 0.17 µm and 18.38 ± 0.44 µm, and 16.81 ± 0.24 µm, 20.12 ± 0.39 µm and 26.37 ± 0.24 µm, respectively, compared to 12.21 ± 0.23 µm for MCC and 13.65 ± 0.21 µm for CMC. The results of effective pore radius indicate the wicking capability as well as the disintegration potential of MCC-SiO2 and CMC-SiO2 conjugates over pure MCC and CMC. The results of wetting time, water absorption ratio and disintegration time for MCC-SiO2 conjugates were found to be in the range of 19 ± 1.21 to 30 ± 1.33 s, 42 ± 0.28 to 49 ± 0.47% and 15 ± 2 to 40 ± 1 s, and for CMC-SiO2 conjugates were found to be in the range of 21 ± 1.13 to 40 ± 1.17 s, 42 ± 0.94 to 49 ± 0.57% and 12 ± 2 to 20 ± 3 s, respectively. Conjugation of MCC and CMC with SiO2 led to the formation of a complex with remarkable tablet superdisintegrant potential that could be used in preparing fast disintegrating tablets.

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Influence of the punch diameter and curvature on the yield pressure of MCC-compacts during Heckel analysis

Cited by 18 publications

References 27 publications

Assessment of co-processing of cellulose II and silicon dioxide as a platform to enhance excipient functionality

Assessment of co-processing of cellulose II and silicon dioxide as a platform to enhance excipient functionality

Development of Corn Starch-Neusilin UFL2 Conjugate as Tablet Superdisintegrant: Formulation and Evaluation of Fast Disintegrating Tablets

Development and Evaluation of MCC-SiO2/CMC-SiO2 Conjugates as Tablet Super-Disintegrants

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