Influence of Thyroid Status on Body Weight Gain, Food Intake and Serum Lipid Levels in Genetically Obese Zucker Rats

Abstract

Body weight gain, food intake and serum concentrations of total lipids, cholesterol, triglycerides, phospholipids and free fatty acids were measured in genetically obese and lean female Zucker rats after surgical thyroidectomy and treatment with 3,5,3'-triiodothyronine (T3) (3 micrograms/100 g body wt per day) for 4 wk. There were large differences in the major serum lipids between the control obese and lean rats. Obese rats were characterized by high levels of the various categories of lipids, especially of triglycerides. Thyroidectomized rats had higher serum concentrations of total lipids and cholesterol than controls in both obese and lean rats. The serum concentration of triglycerides was higher in the thyroidectomized lean rats than in lean controls but lower in their thyroidectomized obese littermates than in obese controls. The T3 treatment resulted in a marked reduction in serum total lipid, cholesterol, triglyceride and phospholipid levels in both thyroidectomized and control obese rats. The same treatment given to thyroidectomized and control lean rats also produced a lower concentration in serum total lipid, cholesterol and triglyceride levels but had no significant effect on serum phospholipid levels. The serum concentration of free fatty acid was not significantly affected by T3 administration in either obese or lean rats. Thyroidectomy induced a lower body weight gain in both obese and lean rats. The T3 treatment restored the body weight gain in the thyroidectomized lean rats but not in the thyroidectomized obese rats, although the food intake was increased by T3.(ABSTRACT TRUNCATED AT 250 WORDS)

Altered regulation of energy homeostasis in older rats in response to thyroid hormone administration

“…It is unlikely that this differential feeding response to T3 was due to the relatively larger size and adiposity of the old rats. Prior studies reported that T3 does not decrease food intake in young obese rats (5,15) and that T3 effectively increases food intake in both lean and obese young rats (15). Unlike young obese rats, old rats have a compromised ability to regain weight after food withdrawal, and central orexigenic neuropeptides are less effective in inducing appetite (16).…”

Relationship between Protein Digestion Products and Plasma Cholesterol in the Rat

“…Since tyrosine is the amino acid precursor of thyroid hormones known to play an important role in the regulation of plasma cholesterol (19,20), a following experiment was carried out to determine if tyrosine availability during protein digestion is a relevant factor which may influence plasma cholesterol in rats, through its effect on plasma thyroid hormone levels (21).…”