Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials

Abstract

Observational studies have shown that low serum levels of vitamin D have been associated with an atherogenic lipid profile. However, the intervention studies gave divergent results. We conducted a meta-analysis of randomized controlled trials that evaluated the effects of vitamin D supplementation on blood lipids. A systematic literature search was conducted via MEDLINE, Cochrane library, and EMBASE for randomized controlled clinical trials assessing the effects of vitamin D supplementation on lipids. The mean change in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) from baseline was treated as a continuous variable. In all, 12 clinical trials consisting of 1346 participants were included in the analysis. The pooled estimate of effect for vitamin D supplementation on LDL-C was 3.23 mg/dl (95% confidence interval, 0.55 to 5.90 mg/dl). No statistically significant effects for vitamin D supplementation were observed for TC, HDL-C and TG (differences in means were 1.52 mg/dl (-1.42 to 4.46 mg/dl), -0.14 mg/dl (-0.99 to 0.71 mg/dl) and -1.92 mg/dl (-7.72 to 3.88 mg/dl) respectively). The lipid modulating effects of vitamin D supplementation should be further investigated though large-scale, randomized trials with adequate doses which can effectively elevated the active form of vitamin D in plasma and with proper population which has hyperlipemia as an inclusion criterion.

The correlation of cardiovascular risk factors and angiographic findings with serum vitamin D levels in patients undergoing coronary angiography

“…22,29 Contrasting was Wang H study where no therapeutic value of Vitamin D supplementation on lipid profile was found. 30 In our study Vitamin D level was inversely co-related with significant CAD angiographically (P=0.02). VDD had significant association in SVD (P=0.046), DVD (P=0.017) and TVD (P=0.012) similar to Syal SK study.…”

Association of Serum Vitamin D Level and Serum Lipids Profile

“…Calcium also plays an important role in glucose uptake by binding to the skeletal cells receptors, insulin receptor affinity, and insulin sensitivity [17]. In a review study by Hao Wang et al, on 12 clinical trials, the mean change of LDL was 3.23 mg/ dL (0.55 to 5.90 mg/dL), while no changes were detected in the level of total cholesterol, TG, and HDL after the administration of vitamin D. However, they suggested further studies to confirm the effect of vitamin D on serum lipid profile [18]. As observed, results of their study were consistent with those of the current study in terms of LDL, HDL, and TG, except for cholesterol, which significantly decreased in the current study.…”

Associations of serum 25-hydroxycholecalciferol and parathyroid hormone with serum lipids differ by sex and vitamin D status

“…However, the majority of previous intervention trials did not report a significant increase in HDL-C or a decrease in unfavourable serum lipids, such as TAG, TC or LDL-C, due to vitamin D supplementation (34)(35)(36) . A recent meta-analysis of twelve randomised controlled trials evaluated the effects of vitamin D supplements on blood lipids and indicated that vitamin D supplementation could increase LDL-C levels, but may not have statistically significant effects on TAG, TC or HDL-C (37) . In our study, neither the use of vitamin D supplements nor the dietary intake levels of vitamin D were significantly associated with serum lipids after adjusting for sex, age, %TBF, iPTH, PAL, time spent outdoors, intake of SFA and alcohol, smoking behaviour and the use of lipid-modifying drugs (data not shown).…”