Influence of zinc ions on structure, bioactivity, biocompatibility and antibacterial potential of melt-derived and gel-derived glasses from CaO-SiO2 system

Cu, Zn doped borate bioactive glasses: antibacterial efficacy and dose-dependentin vitromodulation of murine dendritic cells

“…49 Additionally, the effects of copper and/or zinc doped borate BGs have been evaluated in in vitro studies using fibroblasts, osteoblasts and endothelial cells considering similar BG compositions to those used in the present study. 40,45,46,48,[50][51][52][53][54][55] Although these published results are promising, they also showed that borate BGs, especially when doped with copper, could induce cytotoxic effects, particularly at high doses. 48,50 BGs have been extensively evaluated both in vitro and in vivo in their ability to improve bone and soft tissue regeneration, and so far several FDA approved BG compositions are commercially available in different forms (e.g.…”

“…Whereas ZnO directly leads to the disruption of the bacterial cell wall, Zn 2+ can inhibit the glycolytic processes of bacteria. [38][39][40] The dissolution of BGs and the release of ions (especially in the case of zinc) are strongly dependent on the surrounding pH value. During the growth of bacteria, an acidic environment during the agar diffusion test can occur and may lead to the release of zinc ions, resulting in the antibacterial properties of Zn-doped BGs.…”

Role of Zinc-Doped Bioactive Glass Encapsulated with Microspherical Gelatin in Localized Supplementation for Tissue Regeneration: A Contemporary Review

“…The antibacterial action of ZBG, similar to that of other BGs, is believed to be potent against both gram-positive and gram-negative bacteria [ 21 ]. This effect stems from the cations increasing the pH of the surroundings and from the intracellular incursion of Zn ions, causing disruption of the cell membrane [ 22 ]. The pH change also facilitates local moderation of the inflammatory reaction, and the increased resistance to microbes has shown to improve healing of both soft tissue and hard tissue wounds [ 23 ].…”

Incorporation of Bioactive Glasses Containing Mg, Sr, and Zn in Electrospun PCL Fibers by Using Benign Solvents

“…This behavior decreases glass bioactivity by reducing glass dissolution [80] because cations from silica network are removed. Additionally, by increasing the amount of Zn ions, a decrease in the releasing of alkaline earth ions (i.e., Ca 2+ , Mg 2+ ) and alkali ions (i.e., Na + , K + ) occurs [81][82][83]. This behavior is verified by the low oscillation of pH during soaking time which leads to a low interchange between alkaline, alkali ions, and H 3 O + ions of the surrounding solution, as outlined in previous studies [81][82][83].…”