Influences of age and sex on the validity of bone scintigraphy for the diagnosis of temporomandibular joint osteoarthritis

Kang, Jeong‐Hyun; An, Young‐Sil; Park, Sunghoon; Song, Seung Il

doi:10.1016/j.ijom.2018.05.011

Cited by 9 publications

(8 citation statements)

References 27 publications

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“…The uptake ratios derived from our study were between 2.7 and 3.2 according to different long‐term bone change groups, and group 3 (worsened DJD group) showed the highest value. Age and gender are factors known to affect bone scintigraphy results with age showing a positive association with uptake ratios and females generally expressing higher values 15 . The subjects of our study were confined to females to avoid the effect of sex on results; however, long‐term TMJ bone change prognosis did not show a difference according to age groups in our study and mean age did not show a significant difference according to the groups.…”

Section: Discussionmentioning

confidence: 52%

“…The cut‐off value of 2.53 for initial bone scintigraphy uptake ratio to predict long‐term worsening of TMJ DJD is the first to be suggested. Other cross‐sectional studies proposed bone scintigraphy uptake ratio cut‐off values ranging from 1.55 to 2 for those with TMJ DJD 15,17 . Another study reported an uptake ratio of 4.12 in TMJ osteoarthritis 27 .…”

Section: Discussionmentioning

confidence: 99%

“…13 A few attempts have been made to enhance its diagnostic value through analysing the correlation between bone scintigraphy results, clinical variables and other imaging modalities in a cross-sectional fashion. [14][15][16][17] Unfortunately, no previous study reported on the longitudinal development of TMJ DJD based on initial bone scintigraphy results in spite of the fact that simultaneous assessment of clinical and radiographic findings focusing on longterm longitudinal bone changes could offer more accurate information concerning the diagnostic value of bone scintigraphy in TMJ DJD diagnosis. Due to the additional cost and radiation exposure related to bone scintigraphy, there are considerable limitations in its routine and repeated application.…”

Section: Introductionmentioning

confidence: 99%

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Limited implication of initial bone scintigraphy on long‐term condylar bone change in temporomandibular disorders—Comparison with cone beam computed tomography at 1 year

Bae

Gil

et al. 2021

J of Oral Rehabilitation

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Background The current diagnostic criteria for temporomandibular disorders (TMD) do not require imaging for the diagnosis of degenerative joint disease (DJD) of the temporomandibular joint (TMJ) condyle, and there is a lack of data investigating the effectiveness of imaging modalities in predicting long‐term TMJ DJD prognosis. Objectives To verify the association between initial bone scintigraphy results and long‐term DJD bone changes occurring in the TMJ condyle on cone beam computed tomography (CBCT). Methods Initial bone scintigraphy, panoramic radiography and CBCT results were analysed in relation to long‐term (12 months) TMJ DJD bone change on CBCTs in 55 TMD patients (110 joints). Clinical and radiographic indices were statistically analysed among three groups (improved, no change, and worsened) based on long‐term TMJ DJD prognosis calculated by destructive change index (DCI). Results Neither the uptake ratio nor visual assessment results from initial bone scintigraphy showed a significant difference according to long‐term condylar bone change groups. The cut‐off value of bone scintigraphy uptake ratio was 2.53 for long‐term worsening of TMJ DJD. Worsening of TMJ DJD was significantly associated with the diagnosis based on panoramic radiography (p = .011) and CBCT (p < .001). Initial DCI (β = −.291, p = .046) had a significant association with long‐term worsening of TMJ DJD. Conclusion Initial bone scintigraphy results did not show sufficiently close associations with long‐term TMJ DJD prognosis. This should be considered in the selection process of imaging modalities for TMJ DJD patients. Future studies are needed to develop prognostic indices that comprise both clinical and imaging contents for improved predictive ability.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Limited implication of initial bone scintigraphy on long‐term condylar bone change in temporomandibular disorders—Comparison with cone beam computed tomography at 1 year

Bae

Gil

et al. 2021

J of Oral Rehabilitation

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“…Second, the enrolled patients had a broad age range and an uneven sex distribution. Previous studies have reported that age and sex can affect the uptake of sacroiliac and temporomandibular joints [35,36]; thus, joint uptake ratio in other joint areas might be also influenced by age and sex, which could further affect the diagnostic ability of bone scintigraphy. Third, in diseases with extra-articular manifestations, such as psoriatic arthritis and sarcoidosis, the degree of extra-articular disease burden might affect the interpretation of bone scintigraphy.…”

Section: Discussionmentioning

confidence: 99%

Clinical Use of Quantitative Analysis of Bone Scintigraphy to Assess the Involvement of Arthritis Diseases in Patients with Joint Symptoms

et al. 2020

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We aimed to compare the diagnostic ability of quantitative analysis of bone scintigraphy with that of visual analysis for identifying arthritis disease involvement in patients with joint symptoms. We retrospectively included 93 patients with joint symptoms who underwent Tc-99m methylene diphosphonate bone scintigraphy for evaluating arthritis disease involvement. Bone scintigraphy images were visually and quantitatively analyzed using an in-house software by two reviewers. On quantitative analysis, joint uptake ratio was measured for 64 joints in 14 joints areas. The inter-rater agreement of visual and quantitative analyses was assessed, and diagnostic abilities were compared based on the area under the receiver operating characteristic (ROC) curve (AUC) values. Regarding visual analysis, there was a moderate degree of inter-rater agreement (kappa coefficient of 0.597), while there was a substantial inter-rater agreement (concordance correlation coefficient of 0.987) in the measurement of the joint uptake ratio. The comparisons of ROC curves for the total 5941 joints revealed that the joint uptake ratio had a significantly higher AUC value (0.789) to detect the affected joint than that of the visual analysis (p < 0.001). Quantitative analysis using joint uptake ratio showed substantial reproducibility and higher diagnostic ability to detect joints involving arthritis diseases than visual analysis on bone scintigraphy.

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“…Adolescents with subchondral sclerosis and erosive bony changes were classified as being at the initial stage of OA (TMJOAini) and those with osteophyte formation, bony resorption and generalised sclerosis were classified as being at the severe stage of the OA (TMJOApro). The TMJ OA classification system was mainly based on RDC/TMD image analysis criteria and revised according to the previous reports …”

Section: Methodsmentioning

confidence: 99%

Skeletal maturation and predicted adult height in adolescents with temporomandibular joint osteoarthritis

Hong

Lee

Kang

2019

J of Oral Rehabilitation

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| BACKG ROU N DTemporomandibular disorders (TMDs) encompass a collection of musculoskeletal and neuromuscular conditions which affect the temporomandibular joint (TMJ), the masticatory muscles and associated structures. 1 Osteoarthritis (OA) of the TMJ is the most severe type of manifestation of TMD and featured by deterioration and abrasion of the articular cartilage and concomitant remodelling of the underlying subchondral bone. 2 TMJ OA is epidemiologically different from OA of the hip, hand or knee joints, the development of which is closely related to ageing. 3 Early onset of condition, especially during the pubertal phases has already been described in previous reports. 4,5 The exact pathophysiology of TMJ OA in adolescents, however, has not been clearly revealed.Adolescence is a unique life stage during which an individual undergoes a biopsychological transition from childhood to adulthood, SummaryBackground: The occurrence of osteoarthritis (OA) of the temporomandibular joint (TMJ) in juveniles could be associated with fluctuating levels of oestrogen and growth hormone (GH) during adolescence.Objective: To investigate extent of skeletal maturation and predicted adult height in adolescents with TMJ OA. Method:In total, 155 adolescents (54 males, 101 females; mean age, 14.1 ± 2.0 years) were enrolled. Among them, 19 adolescents (CON) showed no sign of TMD, 50 adolescents exhibited signs of disc displacement but did not have TMJ OA (TMDnoOA), 23 adolescents exhibited the initial stage of TMJ OA (TMJOAini) and 63 adolescents exhibited the severe stage of TMJ OA (TMJOApro). TMJ OA was diagnosed based on the Research Diagnostic Criteria axis I and bone age was estimated using the Greulich-Pyle method. The height, weight and body mass index of participated adolescents were measured and statistically converted to z-scores. The predicted adult height and age of peak height velocity (APHV) were calculated using the BoneXpert® software. Results:In female adolescents, the differences between the chronological and bone ages were significantly higher and the z-score for height was significantly lower in the TMJOApro. Female adolescents with TMJOA exhibited a significantly shorter predicted adult height and earlier APHV than those in the CON and TMDnoOA. Conclusion:The adolescents with TMJ OA exhibited premature skeletal maturations and short predicted adult stature, particularly the female adolescents. K E Y W O R D Sadolescent, female, growth, height, osteoarthritis, temporomandibular joint disorders

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Influences of age and sex on the validity of bone scintigraphy for the diagnosis of temporomandibular joint osteoarthritis

Cited by 9 publications

References 27 publications

Limited implication of initial bone scintigraphy on long‐term condylar bone change in temporomandibular disorders—Comparison with cone beam computed tomography at 1 year

Limited implication of initial bone scintigraphy on long‐term condylar bone change in temporomandibular disorders—Comparison with cone beam computed tomography at 1 year

Clinical Use of Quantitative Analysis of Bone Scintigraphy to Assess the Involvement of Arthritis Diseases in Patients with Joint Symptoms

Skeletal maturation and predicted adult height in adolescents with temporomandibular joint osteoarthritis

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