Influences of<i>IL-1b</i>-3953 C&gt;T and<i>MMP-9-1562C &gt;T</i>Gene Variants on Myocardial Infarction Susceptibility in a Subset of the Iranian Population

Daraei, Abdolreza; MansooriYaser,; ZendebadZahra,; Bazzaz, Javad Tavakkoly; MadadizadehFarzan,; Naghizadeh, Mohammad Mehdi; ArghavaniAli,; MansooriBehnam,

doi:10.1089/gtmb.2016.0240

“…[ 15 – 23 ] Table 2 summarizes the main features of each study. Two studies were based on Asian populations, [ 16 , 19 ] while the other studies were based on Caucasian populations. [ 15 , 17 , 18 , 20 – 23 ] The results of the HWE tests for genotypic distribution in controls are summarized in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Some studies have revealed that IL-1β + 3954C/T is related to an increased risk of MI in Caucasian populations. [ 15 , 17 ] However, Daraei et al [ 19 ] demonstrated that the TT genotype of the IL-1β + 3954C/T polymorphism was associated with a significant MI-protective effect in an Asian population, and Wang et al [ 16 ] showed that IL-1β + 3954C/T was not correlated with MI risk in a Chinese population. MI is a multifactorial disease and polymorphisms may also have different effects on populations as a result of diverse environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk

Fang

¹

,

Xie²,

Lin³

2018

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Background:Many studies have reported that the IL-1β + 3954C/T polymorphism (rs1143634) is related to myocardial infarction (MI). To classify the association between IL-1β + 3954C/T and MI susceptibility, we performed a meta-analysis.Methods:We retrieved relevant literature from electronic databases (Embase, PubMed, Cochrane, and Web of Science). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated with a fixed effect model or a random effect model. Sensitivity analysis and publication bias results are also presented.Results:Nine eligible studies (2299 controls and 2203 cases) were included. The pooled results showed a significant relationship between MI and IL-1β + 3954C/T in an allelic comparison (T vs C: OR = 1.13, 95% CI 1.02–1.25, I2 = 0%, PH = .448) and in a dominant model (TC + TT vs CC: OR = 1.15, 95% CI 1.02–1.30, I2 = 0%, PH = .880). Ethnic subgroup analysis showed similar results in Caucasian populations: an allelic comparison (T vs C: OR = 1.16, 95% CI 1.04–1.29, I2 = 0%, PH = .701), homozygote model (TT vs CC: OR = 1.36, 95% CI 1.04–1.79, I2 = 0%, PH = .673), and dominant model (TC + TT vs CC: OR = 1.17, 95% CI 1.02–1.33, I2 = 0%, PH = .851). In addition, similar effects remained in subgroups analyses of high-quality studies and PCR-RFLP (restriction fragment length polymorphism) data.Conclusion:Our meta-analysis proved that IL-1β + 3954C/T is associated with MI susceptibility, especially among Caucasian populations.

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“…MMP-9 is the active enzyme in MMP family with the largest molecule size of all members. It mediates the formation, development, and rupture of atherosclerotic plaques by mediating metastasis, viability, apoptosis, and extracellular matrix remodeling of vascular smooth muscle cells [ 21 , 22 ]. Studies have found that elevated levels of MMPs are closely associated with the development of unstable angina and AMI [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphism of Matrix Metalloproteinase-9 and Susceptibility to Myocardial Infarction: A Meta-Analysis

Feng

¹

,

Li

²

2022

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Objective. Current findings on the association between MMP-9 rs3918242 and susceptibility to myocardial infarction (MI) are inconsistent, and their definite relationship is discussed in this meta-analysis. Methods. Eligible literatures reporting MMP-9 rs3918242 and susceptibility to MI were searched in PubMed, Cochrane Library, CNRI, and VIP using keywords such as “MMP-9”, “matrix metallopeptidase-9” and “myocardial infarction”, “acute myocardial infarction”, “AMI”, and “polymorphism”. Data from eligible literatures were extracted for calculating OR and corresponding 95% CI using RevMan 5.3 and STATA12.0. Results. Ten independent literatures reporting MMP-9 rs3918242 and susceptibility to MI were enrolled. Compared with subjects carrying CT&TT genotype of MMP-9 rs3918242, susceptibility to MI was lower in those carrying CC genotype ( OR = 1.49 , 95 % CI = 1.19 – 1.86 , P = 0.0004 ). Such a significance was observed in the overdominant ( OR = 1.27 , 95 % CI = 1.14 – 1.41 , P < 0.0001 ) and allele genetic models ( OR = 1.43 , 95 % CI = 1.17 – 1.74 , P = 0.0005 ) as well. This finding was also valid in the Asian population. Conclusions. Mutation on MMP-9 rs3918242 has a potential relevance with susceptibility to MI.

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“…Анализ рецессивной генетической модели (ТТ vs. ТС+СС) выявил, что лиц с ТТ-генотипом было больше в группе контроля (здоровые лица), чем в группе пациентов ИМ (14,2% против 6%, р=0,04). Логистический регрессионный анализ с поправкой на возраст, пол, уровень триглицеридов (ТГ), общего холестерина (ОХ), липопротеинов высокой плотности (ЛПВП), липопротеинов низкой плотности (ЛПНП), артериального давления (АД), сахарный диабет (СД), ИМТ и курение показал протективный эффект в отношении ИМ в гомозиготной генетической модели ТТ-генотипа (ТТ против СС; ОR=0,18, 95% ДИ: 0,04-0,72; р=0,01) и в рецессивной генетической модели (ТТ против ТС+СС, до корректировки ОR=0,39; 95% ДИ: 0,15-0,96; р=0,04 и после корректировки; ОR=0,15; 95% ДИ: 0,04-0,58; р=0,006) [19].…”

Section: Review Interleukin-1в Gene Rs1143634 Polymorphism and Cardio...unclassified

Interleukin-1β gene rs1143634 polymorphism and cardiovascular complications in patients with coronary artery atherosclerosis

Khazova,

Bulashova,

Valeeva

2023

Evrazijskij kardiologičeskij žurnal

0

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The course of heart failure, regardless of its etiology, is associated with local and systemic activation of inflammatory signaling cascades. Identification of the association of candidate cytokine genes with the risk of developing coronary heart disease and chronic heart failure remains a subject of interest for many researchers. The review presents an analysis of studies of the rs1143634 polymorphism of the IL-β gene in relation to the risk of atherosclerotic cardiovascular complications. The presence of the minor allele T is associated with an increase in the concentration of IL-1β in the blood serum. Data on the role of the rs1143634 polymorphism of the IL-β gene in atherosclerotic coronary heart disease, including in combination with chronic heart failure syndrome, are presented, taking into account ethnic characteristics and gender of patients. The carriage of the T allele was associated with the risk of developing atherosclerosis and myocardial infarction. At the same time, it is reported that the C allele and the CC genotype of the rs1143634 polymorphism of the IL-1β gene were a genetic risk factor for the development and progression of heart failure. In a number of studies and meta-analyses, the association of this polymorphism with diseases of the cardiovascular system was not confirmed, but certain trajectories of the risk of complications were identified due to differences in the rs1143634 polymorphism of the IL-β gene in heart failure.

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Influences ofIL-1b-3953 C>T andMMP-9-1562C >TGene Variants on Myocardial Infarction Susceptibility in a Subset of the Iranian Population

Abstract: The findings suggest that the minor alleles of the two polymorphisms under study both have protective effects with respect to MI susceptibility in the Iranian population.

Cited by 7 publications

References 27 publications

Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk

Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk

Genetic Polymorphism of Matrix Metalloproteinase-9 and Susceptibility to Myocardial Infarction: A Meta-Analysis

Interleukin-1β gene rs1143634 polymorphism and cardiovascular complications in patients with coronary artery atherosclerosis

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