Influences of Vitamin B12 Supplementation on Cognition and Homocysteine in Patients with Vitamin B12 Deficiency and Cognitive Impairment

Ueno, Asako; Hamano, Tadanori; Enomoto, Soichi; Shirafuji, Norimichi; Nagata, Miwako; Kimura, Hirohiko; Ikawa, Masamichi; Yamamura, Osamu; Yamanaka, Daiki; Ito, Tatsuhiko; Kimura, Yuri; Kuriyama, Masaru; Nakamoto, Yasunari

doi:10.3390/nu14071494

Cited by 18 publications

(9 citation statements)

References 53 publications

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“…Another investigation highlighted the association between Vitamin B12 deficiency and cognitive impairment. In dementia patients deficient in Vitamin B12, supplementation led to a significant increase in MMSE scores and a decrease in homocysteine levels, further supporting the link between Vitamin B12 levels and cognitive function (20).…”

Section: Discussionmentioning

confidence: 65%

Effects of Vitamin B 12 Supplementation on Cognitive Function in Survivors of Hemorrhagic Stroke

Pervaiz,

Alamgir,

Hashmat

et al. 2023

JHRR

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Background: Hemorrhagic stroke often leads to significant cognitive deficits in survivors. Vitamin B12 plays a crucial role in neurological functions, suggesting its potential in cognitive recovery post-stroke. This retrospective cohort study explored the impact of Vitamin B12 supplementation on cognitive function in hemorrhagic stroke survivors, a subject that holds substantial importance in stroke rehabilitation and patient care. Objective: The primary objective was to evaluate the effectiveness of Vitamin B12 supplementation in improving cognitive function, as measured by MMSE and MoCA scores, in adults who have recently survived a hemorrhagic stroke. Methods: The study included 75 adults diagnosed with hemorrhagic stroke within the last six months. Participants were administered a daily oral dose of 1000 mcg of Vitamin B12 for three months. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) at the start and end of the supplementation period. Additionally, Vitamin B12 levels were measured at baseline and after three months to gauge the physiological uptake of the supplement. Results: The study observed significant improvements in cognitive function, with the MMSE score increasing by an average of 2.2 (p=0.0463) and the MoCA score by 5.8 (p=0.0410). There was also a notable average increase of 400 pg/mL in Vitamin B12 levels (p<0.05). The supplementation was generally well-tolerated, with only 8% of participants reporting minor adverse effects, a rate not statistically significant (p>0.05). Conclusion: The study provides preliminary evidence that Vitamin B12 supplementation may positively impact cognitive function in survivors of hemorrhagic stroke. However, due to the study's limitations, further extensive research is necessary to corroborate these findings and to deepen our understanding of the role of Vitamin B12 in post-stroke cognitive recovery.

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Section: Discussionmentioning

confidence: 65%

Effects of Vitamin B 12 Supplementation on Cognitive Function in Survivors of Hemorrhagic Stroke

Pervaiz,

Alamgir,

Hashmat

et al. 2023

JHRR

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“…For the authors, non-alcoholic fatty liver disease (NAFLD) can be defined as the presence of liver steatosis in patients who consume <20 mg of alcohol per day, as determined via imaging or histology [ 19 ]. Pathophysiological occurrences arising from intracellular homocysteine molecules are one of the factors that can cause NAFLD [ 20 ]. Increased homocysteine can be caused by a vitamin B12 deficiency; vitamin B12 acts as an enzyme cofactor for methionine synthase [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Roselle Flower Extract (Hibiscus sabdariffa Linn.) on Reducing Steatosis and Steatohepatitis in Vitamin B12 Deficiency Rat Model

et al. 2023

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Background and Objectives: Non-alcoholic Fatty Liver Disease (NAFLD) can occur as a result of micronutrient deficiencies. Hibiscus sabdarifa, a plant used in traditional medicine, contains ingredients that can help prevent this process. This study looked at the potency of Hibiscus sabdariffa Ethanol Extract (HSE) to prevent homocysteine-induced liver damage in animals that were deficient in vitamin B12. Materials and Methods: A comparative study of the effects of roselle extract is presented in an experimental design. Thirty Sprague–Dawley rats were divided into six groups using randomization. To demonstrate the absence of liver damage in the experimental animals under normal conditions, a control group was fed a normal diet without HSE. For the induction of liver damage in the experimental animals, the vitamin B12-restricted group was administered a vitamin B12-restricted diet. To test the effect of HSE on liver damage, the treatment group was given HSE along with a vitamin B12-restricted diet. Each group was given two treatment periods of eight and sixteen weeks. These results were compared with the results of the parameter examination between the vitamin B12 restriction group, with and without HSE, using an ANOVA statistic. The data were analyzed with licensed SPSS 20.0 software. Results: HSE significantly increased the blood levels of vitamin B12 while lowering homocysteine levels. The administration of HSE reduced liver damage based on the activity of liver function enzymes in the plasma due to a limitation of vitamin B12. HSE decreased Sterol Regulatory Element-Binding Protein-1c (SREBP1c) and Nuclear Factor Kappa B (NFkB) protein expressions in the liver tissue, but did not decrease Glucose-Regulated Protein 78 (GRP78) protein expression. Significantly, the levels of Tumor Necrosis Factor alpha (TNF-a) and IL-6 in the liver tissue were lower, while the levels of IL-10 and Nuclear factor-erythroid-2 Related Factor 2 (NRF2) were higher with HSE administration. HSE produced a better histopathological profile of the Hematoxylin and Eosin (H&E)–Masson tricrome for inflammation, fat and fibrosis in the liver. Conclusions: In this study, HSE was found to slow the development of liver damage in experimental animals that were given a vitamin B12-deficient diet.

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“…In Japan, family members managing the deposits of elderly people have also been the cause of fraudulent withdrawals and spending of deposits without their permission. Finally, the individuals did not undergo blood tests, including tests for thyroid function and vitamin B levels (Hama et al, 2020 ; Ueno et al, 2022 ).…”

Section: Limitationsmentioning

confidence: 99%

Effectiveness of a self-reporting yes/no survey for dementia screening—trial in Fukui, Japan

Hamano

Nagata²,

Matsubara³

et al. 2023

Front. Aging Neurosci.

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Background: Early intervention for dementia patients is extremely important for the prevention of dementia. However, so far, it is not clear as to what kind of screening will be useful for the early detection of dementia.Objective: We aimed to investigate the relationship between the results of a short self-reporting yes/no survey selected in Kihon Checklist, developed by the Japanese Ministry of Health, Labor and Welfare to identify older adults who are at risk of requiring support/care, and other original items developed by Dementia Prevention Team, Fukui, Japan, and Mini-Mental State Examination (MMSE) scores, and determine the diagnostic efficacy of the self-reporting yes/no survey.Methods: Self-reporting yes/no surveys were conducted for 87,687 individuals aged ≥65 years, living in Fukui, Japan, and did not have Long-Term Care Insurance, Japan. According to the survey results, selected individuals were advised to visit a local hospital to be assessed with MMSE.Results: Individuals who could not make a call by looking up phone numbers and manage their own deposits and savings at the bank or automatic teller machine (ATM) had an increased risk of low MMSE score (≤23; odds ratio: 2.74 [1.89–3.97]; 95% confidence interval: 2.12 [1.46–3.07]).Conclusions: Self-reporting yes/no survey could effectively screen for dementia. Not being able to make a call by looking up phone numbers and not being able to manage their own deposits and savings at the bank or ATM are signs of dementia.

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Influences of Vitamin B12 Supplementation on Cognition and Homocysteine in Patients with Vitamin B12 Deficiency and Cognitive Impairment

Cited by 18 publications

References 53 publications

Effects of Vitamin B 12 Supplementation on Cognitive Function in Survivors of Hemorrhagic Stroke

Effects of Vitamin B 12 Supplementation on Cognitive Function in Survivors of Hemorrhagic Stroke

Effect of Roselle Flower Extract (Hibiscus sabdariffa Linn.) on Reducing Steatosis and Steatohepatitis in Vitamin B12 Deficiency Rat Model

Effectiveness of a self-reporting yes/no survey for dementia screening—trial in Fukui, Japan

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