Ingeniería tisular y miocardio bioartificial

Chachques, Juan Carlos; Herreros, Jesús; Trainini, Jorge C.; Lago, Noemí; Díez-Solórzano, L.; Tascón, V.; Genovese, Jorge

doi:10.1016/s1134-0096(11)70057-2

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…All biomaterials used for direct interaction with biological tissues must comply with certain physiochemical and biological properties (17,18), because they must serve not only to physically support to the cells, but also have to provide the necessary chemical and biological substances to guide cell adhesion, proliferation, differentiation, and organization (18). However, biomaterials should also be efficiently sterilized, i.e.…”

Section: Discussionmentioning

confidence: 99%

Physicochemical and Tissue Response of PLA Nanofiber Scaffolds Sterilized by Different Techniques

Mendieta-Barrañon

Chanes-Cuevas

Álvarez-Pérez

et al. 2018

Odovtos - Int J Dent Sc

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In recent years, tissue engineering has evolved considerably, due to the problems in the biomedical area concerning tissue regeneration therapies. Currently, work has been focused on the synthesis and physicochemical characterization of poly lactic acid scaffolds, a synthetic polyester that has been extensively study for its excellent biocompatibility and biodegradability. Moreover, sterilization strategies of scaffold are a crucial step for its application in tissue regeneration, however, the sterilization process have to maintain the structural and biochemical properties of the scaffold. Therefore, it is very important to carry out studies on the sterilization methods of the sample’s material, since translational medicine is intended for in vivo applications. The aim of the present study was designed to analyze the effects of different sterilization techniques, i.e. ethylene oxide (ETO), gamma radiation (GR) and hydrogen peroxide-based plasma (H2O2) in biodegradable PLA scaffolds, and to determine the best sterilization technique to render a sterile product with minimal degradation and deformation, and good tissue response. Analysis of surface morphology showed that ETO and GR modified the PLA scaffolds without any change in its chemical composition. Moreover, the histological response showed that the scaffolds are biocompatible and those sterilized by GR showed a more severe inflammatory response, accompanied with the presence of giant foreign body cells. In conclusion, the results show that among sterilization techniques used in the preset study, the best results were observed with H2O2 sterilization, since it did not significantly modify the surface structure of the PLA fibers and their in vivo response did not cause an unfavorable tissue reaction.

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Section: Discussionmentioning

confidence: 99%

Physicochemical and Tissue Response of PLA Nanofiber Scaffolds Sterilized by Different Techniques

Mendieta-Barrañon

Chanes-Cuevas

Álvarez-Pérez

et al. 2018

Odovtos - Int J Dent Sc

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“…The migration of MSCs from SIS into the infarcted area and the dif-ferentiation of MSCs into cardiomyocytes and smooth muscle cells were shown [58]. Chachques et al have performed clinical trials by using autologous bone marrow cell-seeded 3D collagen type I matrix and showed the feasibility and safety of the tissue transplantation [59].…”

Section: Three-dimensional Tissues Fabricated By Using Autologous Celmentioning

confidence: 99%

Concise Review: Cell Therapy and Tissue Engineering for Cardiovascular Disease

Haraguchi

Shimizu

Yamato

et al. 2012

Stem Cells Translational Medicine

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Cardiovascular disease is a major cause of morbidity and mortality, especially in developed countries. Various therapies for cardiovascular disease are investigated actively and are performed clinically. Recently, cell-based regenerative medicine using several cell sources has appeared as an alternative therapy for curing cardiovascular diseases. Scaffold-based or cell sheet-based tissue engineering is focused as a new generational cell-based regenerative therapy, and the clinical trials have also been started. Cell-based regenerative therapies have an enormous potential for treating cardiovascular disease. This review summarizes the recent research of cell sources and cell-based-regenerative therapies for cardiovascular diseases.

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“…The migration of MSCs from SIS into the infarcted area and the differentiation of MSCs into cardiomyocytes and smooth muscle cells were shown [58]. Chachques et al have performed clinical trials by using autologous bone marrow cell-seeded 3D collagen type I matrix and showed the feasibility and safety of the tissue transplantation [59].…”

Section: Three-dimensional Tissues Fabricated By Using Autologous Celmentioning

confidence: 99%