Ingenol mebutate gel treatment for actinic cheilitis: report of four cases

Solís, Nerea Barrado; Poveda, Paula Molés; Ruiz, Carolina Martínez; Sanjuan, V. Pont; Pastor, M. Velasco; Estébanez, E. Quecedo; Miquel, Javier Miquel

doi:10.1111/dth.12188

Cited by 13 publications

(9 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, only Barrado-Sol ıs et al (14) have previously reported four cases of AC treated with IM with variable results (14). We consider this option as a valid alternative with need of further study.…”

Section: Discussionmentioning

confidence: 83%

Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases

Flórez

Batalla

Torre

2016

Journal of Dermatological Treatment

View full text Add to dashboard Cite

Actinic cheilitis (AC) can precede the development of squamous cell carcinoma of the lip, a location with high risk of invasiveness and metastasis. We communicate the good results that we obtained when treating seven patients suffering from AC with ingenol mebutate (IM) 0,015% concentration gel on three consecutive days. Three patients achieved complete clearance and four significant improvement. IM is a topical field treatment approved for actinic keratosis. To our knowledge, reported experience in the management of AC with IM is very limited. Local skin responses grade 3 were the main adverse event observed and they resolved in all patients without specific therapy within 1 to 2 weeks. IM is characterized by its rapid clinical effect, its favorable safety profile and its dosing period of only 3 days, shorter than with other field therapies. All these facts make it an attractive new therapy for AC, with need for further study.

show abstract

Section: Discussionmentioning

confidence: 83%

Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases

Flórez

Batalla

Torre

2016

Journal of Dermatological Treatment

View full text Add to dashboard Cite

show abstract

“…Treatments have been used for the treatment of actinic cheilitis, as shown in Table 3 (Robinson 1989;Dufresne et al 2008;Lima Gda et al 2010;Shah et al 2010;Ulrich et al 2011; Jadotte and Schwartz 2012b; Barrado Solís et al 2015).…”

Section: Basic Conceptsmentioning

confidence: 99%

Actinic Cheilitis: Efficacy and Cosmetic Results

Oliveira¹

2016

Clinical Approaches and Procedures in Cosmetic Dermatology

View full text Add to dashboard Cite

Actinic cheilitis (AC) is a common disease caused by long-term solar exposure and is considered a premalignant lesion of the lips. AC has potential to develop into squamous cell carcinoma (SCC) and metastasis. SCC of the lip arising from AC is more prone to metastasis than cutaneous form with rates of the former varying between 3% and 20% and is the most common malignancy of the oral cavity. AC affects especially pale-skinned individuals with poorly pigmented lower lips. The overall survival rate in 5 years is less than 75%. Treatments are difficult because surgical treatment can have significant adverse effects, whereas less invasive procedures may not be as efficient. A high degree of clinical suspicion should be maintained, given the malignant nature of the condition. We emphasize the need for regular follow-up, rigorous clinical exam, and accurate pathologic analysis. The chapter will discuss the efficacy of therapy with photodynamic therapy (PDT) using methyl aminolevulinate and 5-aminolevulinic acid, application times, skin preparation techniques, pain, cosmetic outcome, and patient satisfaction.

show abstract

“…There is no agreement on the frequency in which actinic cheilitis (AC) becomes squamous cell carcinoma (SCC), but SCC of the lip is a highrisk body site for metastatic progression (11% vs. 1% in other locations) and recurrences (Barrado Solís et al, 2015;Benati, Persechino, & Piana, 2017). Thus, it is crucial to treat AC adequately.…”

Section: Introductionmentioning

confidence: 99%

“…Local skin response (LSR) score include erythema, flaking or scaling, crusting, swelling, vesciculation, pustulation, and erosion or ulceration (Rosen, Marmur, Anderson, Welburn, & Katsamas, 2014). Few case series examined the effectiveness of IngMeb for the treatment of AC using clinical and dermoscopy examination (Barrado Solís et al, 2015;Fl orez, Batalla, & De La Torre, 2017;Tzika, Masouy e, M€ uhlstädt, & Laffitte, 2016). Dermoscopy and reflectance confocal microscopy (RCM) are currently the most used noninvasive imaging techniques that help clinicians not only to achieve high diagnostic accuracy for skin cancer diagnosis but also to monitor treatments over time (Fargnoli, Kostaki, & Piccioni, 2012;Longo et al, 2012;Maher et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Dermoscopy and reflectance confocal microscopy for monitoring the treatment of actinic cheilitis with ingenol mebutate gel: Report of three cases

Benati¹,

Pampena²,

Bombonato³

et al. 2018

Dermatologic Therapy

View full text Add to dashboard Cite

Actinic cheilitis (AC) can precede the development of squamous cell carcinoma (SCC) of the lip, a location with higher risk of invasiveness and metastasis. Herein, we reported the use of ingenol mebutate (IngMeb) 0.015% gel on three consecutive days to treat three patients suffering from AC. All the three patients achieved complete clearance of AC with rapid clinical effect, favorable safety profile, good patient's compliance related to short time of applications, and few local skin reactions. So IngMeb is an attractive new therapy for AC. Moreover, the present case report adds further evidence to the usefulness of dermoscopy and Reflectance confocal microscopy (RCM) in the assessment and monitoring of treatment outcome.

show abstract

Ingenol mebutate gel treatment for actinic cheilitis: report of four cases

Cited by 13 publications

References 5 publications

Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases

Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases

Actinic Cheilitis: Efficacy and Cosmetic Results

Dermoscopy and reflectance confocal microscopy for monitoring the treatment of actinic cheilitis with ingenol mebutate gel: Report of three cases

Contact Info

Product

Resources

About