Inhaled frusemide does not affect lung mucociliary clearance in healthy and asthmatic subjects

Hasani, A.; Pavia, D; Spiteri, Monica A.; Yeo, C T; Agnew, J. E.; Clarke, S W; Chung, KF

doi:10.1183/09031936.94.07081497

Cited by 18 publications

(18 citation statements)

References 16 publications

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“…Under conditions of resting ventilation with ambient air, frusemide has no effect on MCC either in asthmatic or healthy subjects [20]. However, there is recent evidence that, under resting conditions, frusemide decreases the clearance of 99m Tc-diethylenetriomine penta-acetic acid (DTPA) in asthmatic subjects [21], suggesting that frusemide may alter the mucosal permeability in asthmatic but not in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Mucociliary clearance during and after isocapnic hyperventilation with dry air in the presence of frusemide

Daviskas

Anderson²,

Gonda³

et al. 1996

Eur Respir J

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M Mu uc co oc ci il li ia ar ry y c cl le ea ar ra an nc ce e d du ur ri in ng g a an nd d a af ft te er r i is so oc ca ap pn ni ic c h hy yp pe er rv ve en nt ti il la at ti io on n w wi it th h d dr ry y a ai ir r i in n t th he e p pr re es se en nc ce e o of f f fr ru us se em mi id de e E. Daviskas*, S.D. Anderson*, I. Gonda + , D. Bailey**, G. Bautovich**, J.P. Seale ++ Mucociliary clearance during and after isocapnic hyperventilation with dry air in the presence of frusemide. E. Daviskas, S.D. Anderson, I. Gonda, D. Bailey, G. Bautovich, J.P. Seale. ©ERS Journals Ltd 1996. ABSTRACT: We have previously shown that mucociliary clearance (MCC) decreased during and increased after isocapnic hyperventilation (ISH) with dry air, both in asthmatic and healthy subjects. Inhaled frusemide, an inhibitor of the Na + /K + /2Cl -and NaCl co-transporters on the basolateral membrane of the epithelial cell, prevents the airway narrowing provoked by ISH with dry air. The co-transport system controls epithelial cell volume and chloride secretion and, thus, frusemide has the potential to modify the rate of recovery of periciliary fluid volume during and after ISH with dry air, and hence affect MCC. Frusemide also blocks mediator release from mast cells, which may also modify the increase in MCC after ISH.Eleven asthmatic and 11 healthy subjects inhaled frusemide (35.7±0.44 mg) or its vehicle, from a Fisoneb ™ ultrasonic nebulizer 30 min before ISH with dry air, on two separate occasions. MCC was measured using 99m Tc-sulphur colloid and a gamma camera. Frusemide, compared to its vehicle, did not affect MCC during or 45 min after ISH. However, in the presence of frusemide, the onset of the increase of MCC after ISH was significantly delayed for approximately 10 min in the whole right lung (p<0.002) and central region (p<0.01) in the asthmatic but not in the healthy subjects.These findings could be explained by frusemide delaying the recovery of the periciliary fluid volume after ISH with dry air and/or interfering with the stimulus that causes the increase in MCC in the asthmatic subjects after ISH. Eur Respir J., 1996, 9, 716- Isocapnic hyperventilation (ISH) with dry air results in significant water loss from the airways whilst bringing the inspired air to alveolar conditions. The water loss from the airways is the stimulus whereby hyperpnoea provokes airway narrowing [1,2]. Mucociliary clearance (MCC) decreases during and increases after ISH with dry air, compared to ISH with warm humid air and nasal breathing at rest [3]. The effect of ISH with dry air on MCC is most likely to be due to a reduction of the depth of the periciliary fluid layer, with the subsequent hyperosmolarity leading to release of mediators [4]. Frusemide, a loop diuretic known to inhibit the Na + /K + /2Cl -and NaCl co-transport systems at the basolateral membrane [5], inhibits the airway narrowing induced by exercise [6], ISH [7,8], and hypertonic saline [9]. Inhibition of the co-transport systems affects the regulatory volume increase (RVI) of the ...

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Section: Discussionmentioning

confidence: 99%

Mucociliary clearance during and after isocapnic hyperventilation with dry air in the presence of frusemide

Daviskas

Anderson²,

Gonda³

et al. 1996

Eur Respir J

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“…5,21,22 Lung mucociliary clearance is influenced by several factors. 5 Mucociliary clearance has been reported to be impaired under mechanical ventilation.…”

Section: Discussionmentioning

confidence: 99%

“…5,21,22 Lung mucociliary clearance is influenced by several factors. 5 Mucociliary clearance has been reported to be impaired under mechanical ventilation. 8 In the present study, trauma produced obvious gradual deteriorating damage on ultrastructure of the tracheobronchial epithelia in time dependent manner.…”

Section: Discussionmentioning

confidence: 99%

“…Lung damage may result from free radicals coming out after central nervous system (CNS) injury, 9 massive sympathetic discharge, 10 -15 and impairment of mucociliary activity. 5 These pathologic pathways may lead to respiratory distress and ALI. Therefore, in case of donation, lower graft survival rates could only be achieved.…”

mentioning

confidence: 99%

“…5 Traumatic brain injury (TBI) represents one of the most important causes of death and disability in modern society. 6 Acute lung injury (ALI) is common in comatose victims with an isolated TBI and is associated with an increased risk of death or a severe neurologic morbidity.…”

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confidence: 99%

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Ultrastructural changes in tracheobronchial epithelia following experimental traumatic brain injury in rats: Protective effect of erythropoietin

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Solaroğlu

Okutan

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Nebulized Furosemide for the Management of Dyspnea: Does the Evidence Support Its Use?

Newton

Davidson

Macdonald

et al. 2008

Journal of Pain and Symptom Management

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Dyspnea is a common and distressing symptom associated with multiple chronic illnesses and high levels of burden for individuals, their families and health care systems. The subjective nature dyspnea and a poor understanding of pathophysiological mechanisms challenge the clinician in developing management plans. Nebulized furosemide has been identified as a novel approach to dyspnea management. This review summarizes published studies, both clinical and experimental, reporting the use of nebulized furosemide. The search criteria yielded 42 articles published in the period 1988 to 2004. Although nebulized furosemide appeared to have a positive influence on dyspnea and physiological measurements, caution must be taken with the results primarily coming from small-scale clinical trials or observation trials. Despite the limitations of the studies reported, given the range of conditions reporting effectiveness of nebulized furosemide, further investigation of this potential novel treatment of dyspnea is warranted.

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Inhaled frusemide does not affect lung mucociliary clearance in healthy and asthmatic subjects

Cited by 18 publications

References 16 publications

Mucociliary clearance during and after isocapnic hyperventilation with dry air in the presence of frusemide

Mucociliary clearance during and after isocapnic hyperventilation with dry air in the presence of frusemide

Ultrastructural changes in tracheobronchial epithelia following experimental traumatic brain injury in rats: Protective effect of erythropoietin

Nebulized Furosemide for the Management of Dyspnea: Does the Evidence Support Its Use?

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