Inhibition effect of glycyrrhiza polysaccharide (GCP) on tumor growth through regulation of the gut microbiota composition

Zhang, Xiaoyu; Zhao, Shuwu; Song, Xinbo; Jia, Jianwei; Zhang, Zhaiyi; Zhou, Huifang; Fu, Hui; Cui, Huantian; Hu, Shuo; Fang, Minjie; Liu, Xiaomin; Bian, Yuhong

doi:10.1016/j.jphs.2018.03.006

Cited by 79 publications

(40 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Poria cocos (Schwein.) F.A.Wolf) and Zingiber Officinale Roscoe (Wang et al, 2020)) and their extracts (such as Citrus reticulata Blanco extract (Zhang et al, 2020c)) and active ingredients (such as glycyrrhiza polysaccharide (Zhang et al, 2018)) in ECD was closely related to the modulation of gut microbiota. A series of studies have been conducted on the effects by which ECD improves obesity.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Erchen Decoction on Gut Microbiota and Lipid Metabolism Disorders in Zucker Diabetic Fatty Rats

et al. 2021

View full text Add to dashboard Cite

Obesity is a chronic metabolic disease caused by genetic and environmental factors that has become a serious global health problem. There is evidence that gut microbiota is closely related to the occurrence and development of obesity. Erchen Decoction (ECD), a traditional Chinese medicine, has been widely used for clinical treatment and basic research of obesity and related metabolic diseases in recent years. It can significantly improve insulin resistance (IR) and lipid metabolism disorders. However, there is no microbiological study on its metabolic regulation. In this study, we investigated the effects of ECD on obesity, especially lipid metabolism and the composition and function of gut microbiota in Zucker diabetic fatty (ZDF) rats, and explored the correlation between the biomarkers of gut microbiota and metabolite and host phenotype. The results showed that ECD could reduce body weight, improve IR and lipid metabolism, and reduce the concentration of free fatty acids (FFA) released from white adipose tissue (WAT) due to excessive lipolysis by interfering with the insulin receptor substrate 1 (IRS1)/protein kinase B (AKT)/protein kinase A (PKA)/hormone-sensitive triglyceride lipase (HSL) signaling pathway in ZDF rats. Additionally, ECD gradually adjusted the overall structure of changed gut microbiota, reversed the relative abundance of six genera, and changed the function of gut microbiota by reducing the content of propionic acid, a metabolite of gut microbiota, in ZDF rats. A potentially close relationship between biomarkers, especially Prevotella, Blautia, and Holdemania, propionic acid and host phenotypes were demonstrated through correlation analysis. The results suggested that the beneficial effects of ECD on obesity, especially lipid metabolism disorders, are related to the regulation of gut microbiota in ZDF rats. This provides a basis for further research on the mechanism and clinical application of ECD to improve obesity via gut microbiota.

show abstract

Section: Introductionmentioning

confidence: 99%

The Effects of Erchen Decoction on Gut Microbiota and Lipid Metabolism Disorders in Zucker Diabetic Fatty Rats

et al. 2021

View full text Add to dashboard Cite

show abstract

“…A significant challenge to acquiring a comprehensive understanding is that multiple factors are in play in tumor microenvironments. Understanding the role of the host's microbiota has been overlooked in the past but has recently become of increasing interest [ 33 , 34 ]. According to the findings of Vétizou et al, specific species of Bacteroides exert an effect upon the antitumor capacity of immune checkpoint inhibitors [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota

Bian

Wan

Liao

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

The flavonoid apigenin is common to many plants. Although the responsible mechanisms have yet to be elucidated, apigenin demonstrates tumor suppression in vitro and in vivo. This study uses an azoxymethane (AOM)/dextran sodium sulfate- (DSS-) induced colon cancer mouse model to investigate apigenin’s potential mechanism of action exerted through its effects upon gut microbiota. The size and quantity of tumors were reduced significantly in the apigenin treatment group. Using 16S rRNA high-throughput sequencing of fecal samples, the composition of gut microbiota was significantly affected by apigenin. Further experiments in which gut microbiota were reduced and feces were transplanted provided further evidence of apigenin-modulated gut microbiota exerting antitumor effects. Apigenin was unable to reduce the number or size of tumors when gut microbiota were depleted. Moreover, tumor inhibition effects were initiated following the transplant of feces from mice treated with apigenin. Our findings suggest that the effect of apigenin on the composition of gut microbiota can suppress tumors.

show abstract

“…Glycyrrhiza uralensis polysaccharide (GCP) extracted from licorice impedes tumor growth and metastasis in mice inoculated with murine colon cancer (CT-26) cells. This is achieved by modifying the composition of gut microbiome such as increased level of Enterorhabdus, Odoribacter, Ruminococcaceae_UCG_014, Ruminococcaceae_UCG_010, Enterococcus, and Ruminiclostridium_5 [52]. Similarly, polysaccharides extracted from jujube have been associated with reductions in inflammation in mouse colon cancer models, due most likely to an associated decrease in Firmicutes and Bacteroidetes taxa in the gut flora [53].…”

Section: The Influence Of Diet On Gut Microbiome and Colorectal Cancementioning

confidence: 99%

Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer

Appunni¹,

Rubens²,

Ramamoorthy³

et al. 2021

Preprint

View full text Add to dashboard Cite

Dietary factors play an important role in shaping the gut microbiome which, in turn, regulates the molecular events in colonic mucosa. The composition and resulting metabolism of the gut microbiome have been implicated in the development of colorectal cancer (CRC). Diets low in dietary fibers and phytomolecules as well as other lifestyle-related factors may predispose to CRC. Emerging evidence demonstrates that the predominance of microbes, such as Fusobacterium nucleatum, can predispose the colonic mucosa to malignant transformation. Dietary and lifestyle modifications have been demonstrated to restrict the growth of potentially harmful opportunistic organisms. In this study, we aim to present evidence regarding the relationship of dietary factors to the gut microbiome and development of CRC.

show abstract

Inhibition effect of glycyrrhiza polysaccharide (GCP) on tumor growth through regulation of the gut microbiota composition

Cited by 79 publications

References 31 publications

The Effects of Erchen Decoction on Gut Microbiota and Lipid Metabolism Disorders in Zucker Diabetic Fatty Rats

The Effects of Erchen Decoction on Gut Microbiota and Lipid Metabolism Disorders in Zucker Diabetic Fatty Rats

Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota

Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer

Contact Info

Product

Resources

About