Inhibition effects of some pesticides and heavy metals on carbonic anhydrase enzyme activity purified from horse mackerel (Trachurus trachurus) gill tissues

Çağlayan, Cüneyt; Taslimi, Parham; Türk, Cebrahil; Gülçın, İlhami; Kandemir, Fatih Mehmet; Demir, Yeliz; Beydemır, Şükrü

doi:10.1007/s11356-020-07611-z

Cited by 78 publications

(51 citation statements)

References 61 publications

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“…Among aquatic pollutants, lead is a major source of poisonings for fish population. Lead is known to cause significant inhibitory effect on carbonic anhydrase activity isolated from horse mackerel ( Trachurus trachurus ) gill and muscle tissues (Caglayan et al, 2019, 2020). Carbonic anhydrase has diverse role in maintaining acid‐base balance and cellular homeostasis (Gundogdu, Turkes, Arslan, Demir, & Beydemir, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Lead is known to cause significant inhibitory effect on carbonic anhydrase activity isolated from horse mackerel (Trachurus trachurus) gill and muscle tissues (Caglayan et al, 2019(Caglayan et al, , 2020 (Gundogdu, Turkes, Arslan, Demir, & Beydemir, 2019). Chelation therapy using di-sodium calcium EDTA and other antidotes is used to tackle lead-induced toxicity but the extensive use of these antidotes is accompanied with a large number of side effects and are not able to manage the lead-induced oxidative stress (Mohamed, Fouda, & Akl, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Recently antioxidative, anti-inflammatory, and antiapoptotic role of zingerone was established in cisplatin-induced nephrotoxic rats by decreasing lipid peroxidation, tumor necrosis factor-α, various interleukins (IL-1β, IL-6, IL-33), nuclear factor kappa B, aquaporin, 1, 8-hydroxy-2′-deoxyguanosine, p53, caspase-3, and Bcl-2-associated x protein (bax) and increasing oxidative enzyme level and B cell lymphoma-2 (Bcl-2) (Kandemir, Yıldırım, Caglayan, Kucukler, & Eser, 2019). Zingerone also produces a significant increase of Paraoxonase-1 enzyme activity in liver and kidney tissues in vancomycin-induced hepatic and renal injuries which is essential for maintenance of antioxidative status by decreasing ROS (Caglayan et al, 2019). Therefore, keeping in mind the anti-oxidative and anti-inflammatory properties of zingerone, we designed the current experiment to find out the hepato and nephro protective potential of zingerone in lead-induced toxicity in Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

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Zingerone prevents lead‐induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats

et al. 2020

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Among the heavy metal poisonings, lead is considered as a major toxic metal causing hematological, neurological, immunological, hepatic, and renal dysfunctions. Lead causes inhibition of ALAD leading to the ALA accumulation inside the cells. Lead also leads to disruption of the anti-oxidative enzyme system, organ function, and lipid membranes of the cell causing oxidative stress. Zingerone, a phenolic alkanone, is an active edible ingredient present in the ginger that possess varied pharmacological properties. The aim of our study was to evaluate the protective effect of zingerone in lead-induced toxicity in wistar rats. ALAD concentration was improved in kidney and liver tissues treated with zingerone. Protective effect of zingerone was observed in terms of significant improvement in kidney and liver histology, anti-oxidant enzyme activity (CAT, SOD, GPx, and GR), organ function parameters, lipid profile, and decreased level of LPO. Therefore, zingerone pretreatment can be a promising agent for alleviation of lead-induced oxidative damage in cells. Practical applications Published reports have revealed that consumption of certain bioactive nutrients for example, flavonoids, mineral elements, and vitamins can offer defense from the environmental lead contamination. Zingerone is a strong anti-oxidant, with very less side effects and has exceptional property of scavenging free radicals, hence reducing the oxidative stresses. This fundamental property of zingerone can alone help in countering the heavy metal toxicity. Different groups have published reported numerous properties of zingerone but as per our understanding till date no study about alleviation of lead toxicity by zingerone in animal model has been undertaken. Hence, we conducted this research to explore the preventive effect of zingerone in lead induced kidney and liver toxicity. The outcome of our study shows potent anti-oxidant effect and ALAD modulatory property of zingerone which makes it suitable edible candidate for use in countering lead toxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Zingerone prevents lead‐induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats

et al. 2020

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“…Dithiocarbamic acid and its derivatives, including TMTD, have indiscriminate (multifarious) effects and disrupt a variety of biochemical processes that involve enzymes containing copper or sulfhydryl groups in pathogenic organisms [12,40,41]. The cytotoxic effect of TMTD results from the oxidation of the thiol group of peptides and proteins by the TMTD disulfide group, resulting in the formation of complexes with metal ions or interactions with essential cellular molecules [42,43]. TMTD is metabolized in the organism to form carbon disulfide and dimethyldithiocarbamate, which are also cytotoxic [44].…”

Section: Discussionmentioning

confidence: 99%

The Fungicide Tetramethylthiuram Disulfide Negatively Affects Plant Cell Walls, Infection Thread Walls, and Symbiosomes in Pea (Pisum sativum L.) Symbiotic Nodules

Gorshkov

Tsyganova

Vorobiev

et al. 2020

Plants

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In Russia, tetramethylthiuram disulfide (TMTD) is a fungicide widely used in the cultivation of legumes, including the pea (Pisum sativum). Application of TMTD can negatively affect nodulation; nevertheless, its effect on the histological and ultrastructural organization of nodules has not previously been investigated. In this study, the effect of TMTD at three concentrations (0.4, 4, and 8 g/kg) on nodule development in three pea genotypes (laboratory lines Sprint-2 and SGE, and cultivar ‘Finale’) was examined. In SGE, TMTD at 0.4 g/kg reduced the nodule number and shoot and root fresh weights. Treatment with TMTD at 8 g/kg changed the nodule color from pink to green, indicative of nodule senescence. Light and transmission electron microscopy analyses revealed negative effects of TMTD on nodule structure in each genotype. ‘Finale’ was the most sensitive cultivar to TMTD and Sprint-2 was the most tolerant. The negative effects of TMTD on nodules included the appearance of a senescence zone, starch accumulation, swelling of cell walls accompanied by a loss of electron density, thickening of the infection thread walls, symbiosome fusion, and bacteroid degradation. These results demonstrate how TMTD adversely affects nodules in the pea and will be useful for developing strategies to optimize fungicide use on legume crops.

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“…Carbonic anhydrases (CAs; EC 4.2.1.1) are zinc enzymes [ 7 ] present in both prokaryotes and eukaryotes, [ 8 ] and they catalyze the reversible hydration of CO 2 efficiently to bicarbonate. [ 9 ] The α‐class CAs are divided into 16 isoforms, [ 10 ] which vary in tissue function, kinetic properties, and expression patterns.…”

Section: Introductionmentioning

confidence: 99%

Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors

Kalaycı

Türkeş

Arslan

et al. 2020

Archiv der Pharmazie

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Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia, memory impairment, cognitive dysfunction, and speech impairment. The utility of cholinergic replacement by acetylcholinesterase (AChE) inhibitors in AD treatment has been well documented so far. Recently, studies have also evidenced that human carbonic anhydrases (hCAs) serve as an important target for AD treatment. In this direction, the improvement of new multitarget drugs, which can simultaneously modulate several mechanisms or targets included in the AD pathway, may be a potent strategy to treat AD. In light of these data for understanding and developing AD‐related multitarget AChE and hCAs inhibitors, in this study, novel methylene‐aminobenzoic acid and tetrahydroisoquinolynyl‐benzoic acid derivatives (4a–g and 6a–g) were designed. The synthesized analogs were experimentally validated for their effects by in vitro and direct enzymatic tests. Also, the compounds were subjected to in silico monitoring with Schrödinger Suite software to assign binding affinities of potential derivatives based on Glide XP scoring, molecular mechanics‐generalized Born surface area computing, and validation by molecular docking. The results revealed that 6c (1,3‐dimethyldihydropyrimidine‐2,4‐(1H,3H)‐dione‐substituted, KI value of 33.00 ± 0.29 nM), 6e (cyclohexanone‐substituted, KI value of 18.78 ± 0.09 nM), and 6f (2,2‐dimethyl‐1,3‐dioxan‐4‐one‐substituted, KI value of 13.62 ± 0.21 nM) from the benzoic acid derivatives in this series were the most promising derivatives, as they exhibited a good multifunctional inhibition at all experimental levels and in the in silico validation against hCA I, hCA II, and AChE, respectively, for the treatment of AD.

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Inhibition effects of some pesticides and heavy metals on carbonic anhydrase enzyme activity purified from horse mackerel (Trachurus trachurus) gill tissues

Cited by 78 publications

References 61 publications

Zingerone prevents lead‐induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats

Zingerone prevents lead‐induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats

The Fungicide Tetramethylthiuram Disulfide Negatively Affects Plant Cell Walls, Infection Thread Walls, and Symbiosomes in Pea (Pisum sativum L.) Symbiotic Nodules

Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors

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