Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis by the naturally occurring plant phenolics caffeic, ellagic, chlorogenic and ferulic acids

Tanaka, Takuji; Kojima, Toshihiro; Kawamori, Toshihiko; Wang, Aijin; Suzui, Masumi; Okamoto, Kiyohisa; Mori, Hideki

doi:10.1093/carcin/14.7.1321

Cited by 295 publications

(154 citation statements)

References 0 publications

Supporting

Mentioning

146

Contrasting

Unclassified

Order By: Relevance

“…Feruloylated arabinoxylans are present in all parts of the grain, mainly in the aleurone layer (75%) and the endosperm 38 . Only a minor part of FA (shown to be an effective antioxidant 7,19,20,44,50 ) is present in malts in free forms 17,28,29 . Malting and mashing result in a limited release of free FA from arabinoxylans 55,56 .…”

Section: Introductionmentioning

confidence: 99%

Dry and Wet Milling of Malt. A Preliminary Study Comparing Fermentable Sugar, Total Protein, Total Phenolics and the Ferulic Acid Content in Non-Hopped Worts

Szwajgier

2011

Journal of the Institute of Brewing

View full text Add to dashboard Cite

In this work, fermentable sugar, total protein, phenolics and ferulic acid content were estimated in sweet worts at different points of lautering. Transfer of these selected malt compounds into worts was analyzed in relation to the method of malt milling (wet milling of malt -the "test worts" or dry milling of maltthe "reference worts"). Glucose, maltose and maltotriose were more rapidly transferred into sweet worts at the early stages of lautering (40 hL and/or 80 hL of wort) after wet milling in comparison to dry milling. Total protein content in the test worts was significantly higher than in the corresponding reference worts at each stage of lautering. Transfer of phenolic compounds and ferulic acid (in the free as well as in the ester form) from the mash into sweet worts was significantly improved by dry milling, but not by wet milling. No difference in the total antioxidant activity was observed between the two types of worts. In conclusion, it can be stated that wet conditioning of malt before milling enhances the fast transfer of fermentable sugars and proteins from the mash into the sweet wort during lautering. Lautering is a time-consuming process, and time reduction without the loss of wort quality should be a priority. Therefore, wet milling can be of interest to professionals in the field as an interesting alternative method to improve the mashing process.

show abstract

Section: Introductionmentioning

confidence: 99%

Dry and Wet Milling of Malt. A Preliminary Study Comparing Fermentable Sugar, Total Protein, Total Phenolics and the Ferulic Acid Content in Non-Hopped Worts

Szwajgier

2011

Journal of the Institute of Brewing

View full text Add to dashboard Cite

show abstract

“…27,28) The AgNORs area and shape rather than number reflect the cell proliferation, 22,23,29) but no modification of AgNORs by coumaperine was seen in this experiment. To investigate the effects of coumaperine on cell proliferation, we examined PCNA at an early stage (8 h after DEN treatment) and AgNORs at a late stage (5 weeks after DEN administration).…”

Section: Discussionmentioning

confidence: 58%

Chemopreventive Effects of Coumaperine from Pepper on the Initiation Stage of Chemical Hepatocarcinogenesis in the Rat

Kitano

Wanibuchi

Kikuzaki

et al. 2000

Japanese Journal of Cancer Research

View full text Add to dashboard Cite

This study was designed to investigate the chemopreventive action of three natural products, coumaperine, aurapten and an extract from rosemary, against the initiation stage of rat hepatocarcinogenesis. Coumaperine has been isolated from white pepper as a naturally occurring antioxidative agent, but its potential modifying effects on carcinogenesis remain unclear. In experiment 1, a modification of the model developed by Tsuda et al. was applied, with assessment of numbers and areas of induced glutathione S-transferase placental form (GST-P)-positive hepatocellular foci in male F344 rats. Coumaperine, aurapten and the extract from rosemary were administered i.g. at 100 mg/kg/day once daily for 5 days with initiation by diethylnitrosamine (DEN) on day 4 (20 mg/kg, i.p.). Numbers and areas of GST-P-positive foci in each group given test chemicals tended to be decreased as compared to the vehicle control group values, significance being achieved for number with coumaperine. Experiment 2 was planned to investigate the mechanism of the inhibitory effects of coumaperine. Livers at 8 h after initiation by DEN were examined with coumaperine administered at 100 mg/kg/day once daily for 3 days. Proliferating cell nuclear antigen (PCNA)-positive cells tended to be decreased as compared to the vehicle control, but no effects on apoptosis or cytochrome P-450 (CYP) 2E1 expression were apparent. Our results suggest that coumaperine provides protection against initiation of hepatocarcinogenesis, and that this is related to inhibition of cell proliferation.

show abstract

“…Chlorogenic acid also shows anticancer properties and helps to protect from oxidative stress (Tanaka et al 1993,Tsuchiya et al 1996 as well as to inhibit the growth of preadipocytes (Hsu et al 2006). Moreover, improving lipid metabolism, it has been proved to be more effective than Caffeic acid as anti-obesity agent in high fat diet induced obese mice (Cho et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Extraction and Evaluation of Nutraceutical Molecules in Wastes of Fruit and Vegetables

Doria¹,

Internationals²

2017

IJFNS

View full text Add to dashboard Cite

Fruit and vegetables wastes not only have no commercial value, but also require expensive operations of removal and disposal, representing a significant cost for the manufacturers of plant products. However, this material may represent an important resource of commercially worth phyto-molecules endowed with various nutraceutical properties. In the present work, we have verified the possibility of using fruit and vegetable waste materials as a source of bioactive compounds. Several nutraceutical compounds of high economic interest were extracted and quantified from various waste plant materials deriving from the production phase ("first-gamma products") or discarded during the preparation of fresh ready-to-cook or ready-to-eat packaged products ("fourth-gamma products"). Obtained results showed that, despite the precarious and uncontrolled conditions which plant wastes products are subjected, the levels of the examined bioactive compounds are present in relevant amount, also in the parts of the plant that are discarded during the preparation of the ready-to-eat/cook products.

show abstract

Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis by the naturally occurring plant phenolics caffeic, ellagic, chlorogenic and ferulic acids

Cited by 295 publications

References 0 publications

Dry and Wet Milling of Malt. A Preliminary Study Comparing Fermentable Sugar, Total Protein, Total Phenolics and the Ferulic Acid Content in Non-Hopped Worts

Dry and Wet Milling of Malt. A Preliminary Study Comparing Fermentable Sugar, Total Protein, Total Phenolics and the Ferulic Acid Content in Non-Hopped Worts

Chemopreventive Effects of Coumaperine from Pepper on the Initiation Stage of Chemical Hepatocarcinogenesis in the Rat

Extraction and Evaluation of Nutraceutical Molecules in Wastes of Fruit and Vegetables

Contact Info

Product

Resources

About