Inhibition of a novel coumarin on an aquatic rhabdovirus by targeting the early stage of viral infection demonstrates potential application in aquaculture

Liu, Lei; Qiu, Tian-Xiu; Song, Dawei; Shan, Li-Peng; Chen, Jiong

doi:10.1016/j.antiviral.2019.104672

Cited by 56 publications

(27 citation statements)

References 40 publications

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“…C2 and C7 were added to aquacultural water, at 28 • C, containing a certain amount of organic material. The half-life of C8 has previously been found to be between 1 and 2 days at 15 • C in aquacultural and sterilized deionized water [33]. In the present study, C2 and C7 showed a similar stability in a shrimp aquacultural environment at 28 • C, where significant degradation occurred between 2 and 3 days, because there was significantly enhanced WSSV replication in vivo at 72 hpi (Figure 5A).…”

Section: The Relative Stability Of C2 and C7 In Aquacultural Watersupporting

confidence: 71%

“…The results showed a suppressed WSSV infection (Figure 4B) and increased the survival rate by up to 40% (Figure 4C,D). Based on the findings of previous studies [17,33,40], we consider that C2 and C7 may have a direct influence on the infectivity of WSSV virion particles, rather than on the host's receptor protein, to block virus infection in the early stage. This therefore provides insight into the properties of coumarin products required for anti-WSSV therapeutic inhibitors and for vaccine development.…”

Section: Pre-exposure Of Antiviral Compounds and Preincubation Of Wssv Infectionmentioning

confidence: 94%

“…Moreover, the component complexity and cost-effectivity of these strategies remain limitations of these approaches [28]. Thus, naturally occurring biological compounds have been isolated and purified from plants or synthesized as potential antiviral agents [19,21,24,[31][32][33]. For example, epigallocatechin gallate is a promising therapeutic agent against grass carp reovirus (GCRV) infection by blocking its binding to laminin receptors [34]; saikosaponin D efficiently suppressed spring viremia of carp virus (SVCV) replication in vivo, prolonging the survival of zebrafish and common carp [35].…”

Section: Anti-wssv Activity Of C2 and C7 In Shrimp Larvaementioning

confidence: 99%

“…The results showed a suppressed WSSV infection (Figure 4B) and increased the survival rate by up to 40% (Figure 4C,D). Based on the findings of previous studies [17,33,40], we To address the negative effects of C2 and C7 during the WSSV infection cycle, the virus was pre-incubated with the compounds for 1-4 h prior to infection of larvae (Figure 4). The results showed a suppressed WSSV infection (Figure 4B) and increased the survival rate by up to 40% (Figure 4C,D).…”

Section: Pre-exposure Of Antiviral Compounds and Preincubation Of Wssv Infectionmentioning

confidence: 99%

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Small Molecule Inhibitors of White Spot Syndrome Virus: Promise in Shrimp Seedling Culture

Liu

Shan

Zhou

et al. 2021

IJMS

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Rapid production of prawn (Litopenaeus vannamei) under artificial pressure can result in a series of obvious challenges and is vulnerable to serious losses related to aquatic environmental issues and the unrestrained outbreak of white spot syndrome (WSS). However, to date, there are no therapeutic strategies to contain the spread of the virus. Here, we synthesized 27 coumarin deriv-atives and evaluated their anti-white spot syndrome virus (WSSV) activity in L. vannamei larvae. We demonstrated that electron-withdrawing and electron-giving substituent groups play an im-portant role in reducing toxicity and WSSV replication, respectively. Two coumarin C2 (2-amino-5-oxo-4-(p-tolyl)-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile) and C7 (2-amino-4-(4-chlorophenyl)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile) were regarded as the most promising anti-WSSV compounds with maximum antiviral response <5% and median effective concentration <10 mg/L. The mortality of WSSV-infected larvae decreased by more than 60% after exposure to C2 and C7. With continuous immersion of C2 and C7 exchange, the mortality further decreased to 40% at 120 h.Additionally, C2 and C7 are the relatively stable in aquacultural water, making these agents

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Section: The Relative Stability Of C2 and C7 In Aquacultural Watersupporting

confidence: 71%

Section: Pre-exposure Of Antiviral Compounds and Preincubation Of Wssv Infectionmentioning

confidence: 94%

Section: Anti-wssv Activity Of C2 and C7 In Shrimp Larvaementioning

confidence: 99%

Section: Pre-exposure Of Antiviral Compounds and Preincubation Of Wssv Infectionmentioning

confidence: 99%

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Small Molecule Inhibitors of White Spot Syndrome Virus: Promise in Shrimp Seedling Culture

Liu

Shan

Zhou

et al. 2021

IJMS

Self Cite

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“…increased the survival of zebrafish infected with SVCV and reduced the viral load in zebrafish tissues, which may have been a consequence of the higher IFN and antioxidant response observed in the animals treated with the coumarin derivative (Shen et al 2018a,b). Preincubation of SVCV with coumarin derivative C3007 also reduced the infection of EPC cells by destroying the infectivity of the virion particles and suppressing the virus-binding process (Liu et al 2020b). Moreover, C3007 administered i.p.…”

Section: Implementation Of Natural Compounds As Antiviralsmentioning

confidence: 99%

Compilation of antiviral treatments and strategies to fight fish viruses

Pereiro

Figueras

Novoa

2020

Reviews in Aquaculture

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The implementation of antiviral treatments and prophylaxis strategies in fish aquaculture needs to be established. The absence of commercial vaccines for most viral diseases affecting economically relevant fish species, and the total lack of treatments to fight these diseases once they have emerged in a fish farm remains one of the main bottlenecks in fish aquaculture production. However, although no antivirals are currently applied on farms, a great number of investigations have been conducted to assess the potential use of antiviral treatments against several fish viruses. Although most of these works were based on in vitro approaches, some included in vivo experiments to demonstrate the potential applicability of these treatments. This review summarizes the investigations conducted both in vitro and in vivo in the field of antiviral treatments against fish viruses. The highlighted works include those using piscine and non-piscine proteins with antimicrobial functions, metabolites, chemical compounds (some of which are used in medicine to treat human viruses), bioactive compounds mainly isolated from plants and bacteria, and emerging DNA-and RNA-based therapeutics. This information can be used for developing both specific and broad-spectrum antiviral strategies to be further used in the aquaculture industry, and it may even provide interesting indications for biomedical research.

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Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity

Zhong

et al. 2022

Phytotherapy Research

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Xanthotoxin (XAT) is a natural furanocoumarins, a bioactive psoralen isolated from the fruit of the Rutaceae plant Pepper, which has received increasing attention in recent years due to its wide source and low cost. By collecting and compiling literature on XAT, the results show that XAT exhibits significant activity in the treatment of various diseases, including neuroprotection, skin repair, osteoprotection, organ protection, anticancer, antiinflammatory, antioxidative stress and antibacterial. In this paper, we review the pharmacological activity and potential molecular mechanisms of XAT for the treatment of related diseases. The data suggest that XAT can mechanistically induce ROS production and promote apoptosis through mitochondrial or endoplasmic reticulum pathways, regulate NF‐κB, MAPK, JAK/STAT, Nrf2/HO‐1, MAPK, AKT/mTOR, and ERK1/2 signaling pathways to exert pharmacological effects. In addition, the pharmacokinetics properties and toxicity of XAT are discussed in this paper, further elucidating the relationship between structure and efficacy. It is worth noting that data from clinical studies of XAT are still scarce, limiting the use of XAT in the clinic, and in the future, more in‐depth studies are needed to determine the clinical efficacy of XAT.

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Inhibition of a novel coumarin on an aquatic rhabdovirus by targeting the early stage of viral infection demonstrates potential application in aquaculture

Cited by 56 publications

References 40 publications

Small Molecule Inhibitors of White Spot Syndrome Virus: Promise in Shrimp Seedling Culture

Small Molecule Inhibitors of White Spot Syndrome Virus: Promise in Shrimp Seedling Culture

Compilation of antiviral treatments and strategies to fight fish viruses

Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity

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