Inhibition of adiposity and related metabolic disturbances by polyphenol-rich extract of Boswellia serrata gum through alteration of adipo/cytokine profiles

Gomaa, Adel A.; Farghaly, Hanan S.M.; Elsers, Dalia A.; Farrag, Magda M.Y.; Al-Zokeim, Nahla I

doi:10.1007/s10787-018-0519-4

Cited by 21 publications

(7 citation statements)

References 30 publications

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“…Many studies suggested that the pathological hallmarks of type 2 diabetes-related dementia are tau-related neurofibrillary tangles and not amyloid-beta plaques [ 59 – 61 ]. Intervention for AD may be more successful through inhibiting insulin resistance and abnormal GSK-3β activity [ 7 , 43 , 60 , 61 ]. PCDE in the present study reduced insulin resistance and hippocampal GSK-3β activity and improved all toxic consequences features of AD that have been detected in the T2D animal model.…”

Section: Discussionmentioning

confidence: 99%

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RETRACTED ARTICLE: Polyphenols from Conyza dioscoridis (L.) ameliorate Alzheimer’s disease- like alterations through multi-targeting activities in two animal models

Gomaa

Farghaly

Makboul

et al. 2022

BMC Complement Med Ther

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Background Recent investigations suggested that anticancer agents may inhibit the progression of Alzheimer's disease (AD) pathology. Conyza dioscoridis (L.) was demonstrated to have anticancer, antioxidant, anti-inflammatory and antidiabetic effects. This study was carried out to investigate the efficacy of polyphenols from Conyza dioscoridis (L.) extract (PCDE) on AD. Methods Impacts of 3 doses of PCDE and donepezil, a reference drug, on the features of Alzheimer's disease in two animal models were investigated. Results PCDE ameliorated the memory and learning impairment shown in rats following a single dose of scopolamine (scopolamine model) or 17 weeks of high-fat/high-fructose(HF/Hfr) diet coupled with a single dose of streptozotocin, (25 mg/kg) (T2D model). They reduced significantly the high hippocampal cholinesterase activity in the two models of rats. Administration of PCDE for 8 weeks in the T2D model showed a significant reduction in hippocampal GSK-3β, caspase-3 activity and increase in the inhibited glutamate receptor expression (AMPA GluR1 subunit and NMDA receptor subunits NR1, NR2A, NR2B). A significant reduction of HOMA-insulin resistance and serum hypercholesterolemia was observed. The Tau hyperphosphorylation and Aβ 1–42 generation in the hippocampal of T2D rats were significantly decreased by PCDE. Modulation of the oxidative stress markers, (rise in GH and SOD; decrease in MDA levels) and a significant reduction of TNF-α and IL-1β in the hippocampus of T2D rats treated by PCDE extract were important findings in this study. The highest dose tested was 4% of the highest safe dose. Conclusion Our study suggests that PCDE is multi-targeting agent with multiple beneficial activities in combating features of AD. This study may provide a novel therapeutic strategy for AD treatment that warrants clinical studies.

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Section: Discussionmentioning

confidence: 99%

“…Assessment of peripheral insulin resistance was carried out as described by Wang et al . [ 42 ] and Gomaa et al[ 43 ] using the homeostatic model assessment of insulin resistance (HOMA-IR) index. The HOMA-IR was calculated according to the following formula: …”

Section: Biochemical Assaymentioning

confidence: 99%

RETRACTED ARTICLE: Polyphenols from Conyza dioscoridis (L.) ameliorate Alzheimer’s disease- like alterations through multi-targeting activities in two animal models

Gomaa

Farghaly

Makboul

et al. 2022

BMC Complement Med Ther

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“…Obesity was induced using HFD for 8 weeks, according to the method of Marques et al . with slight modifications and Gomaa et al . The composition of HFD was (wt/wt): 21.2% fat, 49% carbohydrate (34% sucrose plus 15% corn starch), 17.3% protein, 5.0% fibre, 3.5% minerals, 1% vitamin mixture and 3% hydrogenated vegetable oil.…”

Section: Methodsmentioning

confidence: 99%

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

Gomaa

Elsers

Al-Zokeim

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives To determine the efficacy of Corchorus olitorius (C. olitorius) leaf extract in the prevention of metabolic syndrome induced in rats by high‐fat diet (HFD) and compare it with that of orlistat. Methods Phytochemical analysis was performed. Effect of orlistat and C. olitorius extract on lipase activity and acute food intake were investigated. Body weight, biochemical parameters and histopathological examination were demonstrated. Key findings Corchorus olitorius extract inhibited the pancreatic lipase activity, but orlistat was more potent. Cumulative food intake has not changed by the tested agents. In obese rats, C. olitorius or orlistat significantly decreased weight gain and visceral white adipose tissue. They exhibited a significant reduction in serum glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol, free fatty acids, IL‐1β, tumour necrosis factor‐α (TNF‐α), insulin and leptin levels of obese rat groups while high density lipoprotein cholesterol and adiponectin levels were significantly increased by them. Histopathological examination of the liver revealed that C. olitorius was more effective than orlistat in the alleviating of steatosis and adipocyte hypertrophy shown in obese control rats. Conclusions Corchorus olitorius is effective as orlistat in preventing obesity, hyperlipidaemia, steatosis and insulin resistance. These actions may be mediated by inhibiting of lipase activity, TNF‐α, IL‐1β and leptin resistance along with increasing of adiponectin.

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“…Translational research with "obesogenic" environmental factors such as HFD has shown that animal models play an important role in the identification and testing of cytoprotective compounds for RAT, and this step is essential for identification of targets for pathogenesis-based anti-obesity drugs [24][25][26]. The HFD model, as a high-caloric diet, provides the development of postprandial hyperglycemia that, in turn, promotes excess oxidation caused by nutrients and release of mediators which induce oxidative stress related to metabolic responses [27].…”

Section: Discussionmentioning

confidence: 99%

Novel approach for discrimination of eosinophilic granulocytes and evaluation of their surface receptors in a multicolor fluorescent histological assessment

Bila¹,

Schneider²,

Peshkova³

et al. 2020

Ukr.Biochem.J

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Remodeling of adipocytes in mesentery (aM) associated with nutritional overload from high fructose diet (hFD) is a source of several comorbidities. however, its pathogenesis is still unclear and there are no specific effective drugs for AM remodeling. Recently hydrogen sulfide (H 2 S) demonstrated potent cytoprotective actions. The purpose of this study was to investigate the effects and underlying mechanisms of AM remodeling in rats fed hFD and with h 2 S pre-treatment. adult male rats on standard diet (SD, control group) or hFD that underwent acute water-immersion restraint stress (WIS) were evaluated for subcellular aM adaptive responses by electron microscopy. The effects on AM of exogenous sodium hydrosulfide (NaHS, 5.6 mg/ kg/day for 9 days) and the Н 2 S-releasing aspirin (aSa) derivative (h 2 S-ASA , 17.5 mg/kg/day) vs conventional ASA (10 mg/kg/day) vs vehicle were investigated. Serum glucose level, thiobarbituric acid reactive substances (TBARS), and activities of cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) were examined biochemically using spectrophotometry. In the HFD groups, treatment with NaHS protected aM, as mesenteric microvascular endothelial and sub-endothelial structures were observed vs the vehicletreated group that had signs of endothelial dysfunction, aM damage and dysfunctional mitochondria. The effect of H 2 S-aSa was characterized by protection of aM against hFD and WIS-induced injury, with lower TBARS blood level and increased CSE and CBS activities. Carbohydrate overload for 4 weeks is sufficient to cause AM oxidative damage, mitochondrial dysfunction and endothelial changes. H 2 S plays an important role in mesenteric adipocyte cellular survival against HFD-induced oxidative stress by decreasing overproduction of TBaRS and mitochondrial dysfunction. The use of h 2 S could lead to a novel approach for anti-obesity treatment.K e y w o r d s: hydrogen sulfide (H 2 S), thiobarbituric acid reactive substances (TBaRS), cystathionine gamma-lyase (CSE), cystathionine beta-synthase (CBS), oxidative stress, adipocytes, mesentery, mitochondria.

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Inhibition of adiposity and related metabolic disturbances by polyphenol-rich extract of Boswellia serrata gum through alteration of adipo/cytokine profiles

Abstract: Boswellia serrata is as effective as orlistat in preventing obesity, hyperlipidemia, steatosis and insulin resistance. These actions may be mediated by suppression of food intake and decrease levels of TNF-α, IL-1β and leptin resistance along with increasing adiponectin.

Cited by 21 publications

References 30 publications

RETRACTED ARTICLE: Polyphenols from Conyza dioscoridis (L.) ameliorate Alzheimer’s disease- like alterations through multi-targeting activities in two animal models

RETRACTED ARTICLE: Polyphenols from Conyza dioscoridis (L.) ameliorate Alzheimer’s disease- like alterations through multi-targeting activities in two animal models

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

Novel approach for discrimination of eosinophilic granulocytes and evaluation of their surface receptors in a multicolor fluorescent histological assessment

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