2004
DOI: 10.1016/j.bcp.2003.11.003
|View full text |Cite
|
Sign up to set email alerts
|

Inhibition of ATP-sensitive K+ channels by taurine through a benzamido-binding site on sulfonylurea receptor 1

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
17
0

Year Published

2004
2004
2023
2023

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 35 publications
(18 citation statements)
references
References 34 publications
1
17
0
Order By: Relevance
“…In isolated rat liver mitochondria, TAU-enhanced Ca 2+ uptake via the uniport system [6]. In rat pancreatic β-cells, TAU increased insulin secretion and Ca 2+ oscillation via inhibition of the K ATP channels due to its interaction with a benzamido-binding site on SUR1 [8]. TAU also restores impaired glucose-induced insulin secretion in uncoupling protein 2-overexpressing β-cells by inducing Ca 2+ sequestration into the mitochondrial matrix [9].…”
Section: Discussionmentioning
confidence: 86%
“…In isolated rat liver mitochondria, TAU-enhanced Ca 2+ uptake via the uniport system [6]. In rat pancreatic β-cells, TAU increased insulin secretion and Ca 2+ oscillation via inhibition of the K ATP channels due to its interaction with a benzamido-binding site on SUR1 [8]. TAU also restores impaired glucose-induced insulin secretion in uncoupling protein 2-overexpressing β-cells by inducing Ca 2+ sequestration into the mitochondrial matrix [9].…”
Section: Discussionmentioning
confidence: 86%
“…At high concentrations (Ͼ10-fold those used here), taurine can alter calcium flux (37) and interact with GABA receptors (35); however, whether this occurs in the ␤-cell is not known. At high concentrations, taurine can also close ATP-sensitive K ϩ channels in ␤-cells (36). In support of the action of taurine as an antioxidant, the other antioxidant used, NAC, proved to be equally effective as taurine in preventing the FFA-induced decrease in GSIS; however, because NAC can be converted to taurine, we cannot totally exclude that the NAC effect may also be independent of its antioxidant properties.…”
Section: Discussionmentioning
confidence: 94%
“…Moreover, it has been shown that taurine increases glucose sensitivity of UCP2-overexpressing cells by enhancing mitochondrial metabolism [11], at least partially by acting on the mechanism for Ca 2+ sequestration into the mitochondrial matrix [12]. Finally, taurine inhibits ATP-sensitive K + (KATP) channel activity in adult rat beta cells [13].…”
Section: Introductionmentioning
confidence: 99%