Inhibition of CCl4-induced liver fibrosis by Piper longum Linn.?

Christina, A. J. M.; Saraswathy, Ganesan Rajalakshmi; Robert, Séverine; Ramalingam, Kothai; Chidambaranathan, N.; Ganesan, Nalini; Therasal, R.L.

doi:10.1016/j.phymed.2004.01.009

Cited by 38 publications

(25 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PL has recently been demonstrated to have beneficial effects on a plethora of pathophysiologic pathways involved in the natural history of major human diseases; e.g., oxidative stress [4], inflammation [5], hemostasis [6], hyperlipidemia [7], dementia [8] and pain [9]. Furthermore, PL inhibits infectious pathogens (e.g., amoebae [10], schistosoma [11], fungi [12]) or their insect vectors (e.g., mosquitoes at larval [13] or adult [14] stages of development); protects tissues, such as liver, from damage induced by toxic chemicals [15] or ionizing radiation [16]; and, of importance for cancer research, hampers the growth and dissemination of neoplastic cells in vitro [17] and in vivo [18]. …”

Section: Introductionmentioning

confidence: 99%

Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro

et al. 2013

View full text Add to dashboard Cite

Piperlongumine (PL), a pepper plant alkaloid from Piper longum, kills solid tumor cells in a highly selective, potent fashion. To evaluate whether PL may have similar effects on malignant blood cells, we determined the efficacy with which PL inhibits the B-lymphocyte derived neoplasm, Burkitt lymphoma (BL). Low micromolar concentrations of PL (IC50 = 2.8 × 8.5 μM) curbed growth and survival of two EBV+ BL cell lines (Daudi, Raji) and two EBV− BL cell lines (Ramos, DG-75), but left normal peripheral blood B-lymphocytes unharmed. PL-dependent cytotoxicity was effected in part by reduced NF-κB and MYC activity, with the former being caused by inhibition of IκBα degradation, nuclear translocation of p65, and binding of NF-κB dimers to cognate DNA sequences in gene promoters. In 4 of 4 BL cell lines, the NF-κB/MYC-regulated cellular target genes, E2F1 and MYB, were down regulated, while the stress sensor gene, GADD45B, was up regulated. The EBV-encoded oncogene, LMP-1, was suppressed in Daudi and Raji cells. Considering that NF-κB, MYC and LMP-1 play a crucial role in the biology of many blood cancers including BL, our results provide a strong preclinical rationale for considering PL in new intervention approaches for patients with hematologic malignancies.

show abstract

Section: Introductionmentioning

confidence: 99%

Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The spectrum of alcoholic liver disease ranges from simple steatosis, to inflammation, steatohepatitis, fibrosis, cirrhosis and cancer (Mathurin, 2009). Thus, recently, some anti-alcoholic liver disease candidates from herbal prescriptions (Batey et al, 2000;Echard et al, 2001;Tang et al, 2006) and extracts (Christina et al, 2006;Kim et al, 2015;Lin et al, 2002;Park et al, 2002;Tseng et al, 1997) have been attractive with their good efficacy and little toxicity. Essential oil of P. koraiensis was reported to have hypoglycemic potential in streptozotocin-treated mice and HIT-T15 pancreatic β cells (Joo et al, 2013) and exert anticancer effect in colorectal cancer cells (Cho et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Ethanol Extract of Pinus koraiensis Leaf Ameliorates Alcoholic Fatty Liver via the Activation of LKB1–AMPK Signaling In Vitro and In Vivo

Hong

Lee

Kim

et al. 2017

Phytotherapy Research

View full text Add to dashboard Cite

Although Pinus koraiensis leaf (PKL) was reported for its anti-diabetes, anti-obesity and anticancer effects as a folk remedy, the inhibitory effect of PKL on alcoholic fatty liver has never been elucidated yet. This study investigated the molecular mechanisms of PKL on alcoholic fatty liver in HepG2 cells, Sprague Dawley (SD) rats and Imprinting Control Region (ICR) mice. Pinus koraiensis leaf increased phosphorylation of liver kinase B1 (LKB1)/AMP-activated protein kinase signaling, low-density lipoprotein receptor and decreased fatty acid biosynthesis-related proteins such as sterol regulatory element-binding protein 1c, fatty acid synthase, 3-hydroxy-3-methylglutaryl-CoA reductase in HepG2 cells. In SD rats with 25% alcohol-induced fatty liver, PKL suppressed the levels of aspartate aminotransferase and triglyceride and also enhanced the activities of antioxidant enzymes including superoxide dismutase, glutathione peroxidase and glutathione s-transferase compared with untreated control. Furthermore, PKL increased serum alcohol dehydrogenase and serum aldehyde dehydrogenase, but decreased serum alcohol concentration in ICR mice after alcohol administration. Consistently, histochemical analysis revealed that PKL attenuated alcohol-induced fatty liver in SD rats. Overall, these findings suggest that PKL ameliorates alcohol-induced fatty liver via activation of LKB1-AMP-activated protein kinase and modulation of proteins related to lipogenesis synthesis, cholesterol synthesis and fatty acid oxidation. Copyright © 2017 John Wiley & Sons, Ltd.

show abstract

“…The doses were 0.5 ml (Maheswari & Rao, 2005), 0.8 ml (Özbek et al, 2004) or 1 ml/kg (Somasundaram et al, 2010). In 14 days experiment carbon tetrachloride/liquid paraffin mixture (1:1) was administered intraperitoneal every 72 hours (Christian et al, 2006). Chronic reversible cirrhosis were induced in rats by oral administration of mixture of 20% carbon tetrachloride in corn oil at 0.5mL/ kg body weight doses twice a week (Monday and Thursday) for 6 weeks (Hernandez-Munoz et al, 2001).…”

Section: Multi Doses Carbon Tetrachloride-induced Liver Toxicitymentioning

confidence: 99%