Inhibition of cytokine‐induced vascular cell adhesion molecule‐1 expression; possible mechanism for anti‐atherogenic effect of Agastache rugosa

Abstract

Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) play an important role during the early stages of atherogenesis. Agastache rugosa has an anti-atherogenic effect in low density lipoprotein receptor 3 3/3 3 mice. Moreover, A. rugosa reduced macrophage infiltration and VCAM-1 expression has been localized in aortic endothelium that overlies early foam cell lesions. This study ascertained that tilianin (100 W WM), a major component of A. rugosa, inhibits the tumor necrotic factor-K K (TNF-K K)-induced expression of VCAM-1 by 74% in cultured human umbilical vein endothelial cells (HUVECs). Also, tilianin (100 W WM) reduced TNF-K K-induced activation of nuclear factor-U UB in HUVECs. ß

Rosmarinic acid production in hairy root cultures of Agastache rugosa Kuntze

“…It is used in Chinese traditional medicine for the treatment of cholera, vomiting, and miasma, and has been reported to have antitumor, antifungal, antiatherogenic and cytotoxic activities (Oh et al 2005;Shin and Kang 2003;Hong et al 2001).…”

Protein kinase G-dependent heme oxygenase-1 induction by Agastache rugosa leaf extract protects RAW264.7 cells from hydrogen peroxide-induced injury

“…Furthermore, HO-1 null mice and HO-1 deficient humans showed reduction of the host's defense against oxidative stress (Poss and Tonegawa, 1997;Yachie et al, 1999). The plant Agastache rugosa Kuntze contains several kinds of flavonoids such as tilianin, acacetin, linarin, agastinol, agastenol and agastachoside (Hong et al, 2001), and tilianin is considered as a main constituent of Agastache rugosa. This plant has a variety of physiological and pharmacological activities (Hong et al, 2001;Lee et al, 2002).…”

“…The plant Agastache rugosa Kuntze contains several kinds of flavonoids such as tilianin, acacetin, linarin, agastinol, agastenol and agastachoside (Hong et al, 2001), and tilianin is considered as a main constituent of Agastache rugosa. This plant has a variety of physiological and pharmacological activities (Hong et al, 2001;Lee et al, 2002). It has been reported that Agastache rugosa extracts inhibited cytokine induced vascular cell adhesion molecule-1 in human umbilical vein endothelial cells (HUVECs) (Hong et al, 2001), and inhibited apoptosis in leukemia cells .…”

“…This plant has a variety of physiological and pharmacological activities (Hong et al, 2001;Lee et al, 2002). It has been reported that Agastache rugosa extracts inhibited cytokine induced vascular cell adhesion molecule-1 in human umbilical vein endothelial cells (HUVECs) (Hong et al, 2001), and inhibited apoptosis in leukemia cells . These findings suggest that Agastache rugosa may be valuable source for the treatment of anti-inflammatory and oxidative stress-induced disorders.…”

Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice

“…In our previous study, we have reported that tilianin, a major component of Agastache rugosa (Labiatae) significantly inhibits the tumor necrotic factor-(TNF-)-induced expression of vascular cell adhesion molecule-1 (VCAM-1) in human umbilical vein endothelial cells (HUVEC) as its potential antiatherogenic mechanism (Hong et al, 2001;Nam et al, 2005). However, it has not been determined the effect of tilianin on NO production.…”