Inhibition of doxorubicin-induced mutagenicity by Baccharis dracunculifolia

Lack of clastogenic/genotoxic effects of Baccharis dracunculifolia extract on Swiss mouse peripheral blood cells

“…The same authors even observed that the extract causes a significant reduction in the frequency of polychromatic erythrocytes with micronuclei induced by doxorubicin, probable due to the antioxidant properties of the flavonoids present in this plant. In conclusion, the results obtained in the present study show that the mixed compounds present in crude water-ethanol extract of B. dracunculifolia did not induce any clastogenic/genotoxic response in blood cells of mice, when administered at high, single doses, confirming the results of Resende et al (2007).…”

“…mutagenic effect on the rat erythrocyte micronucleus test (Resende et al, 2007). The same authors even observed that the extract causes a significant reduction in the frequency of polychromatic erythrocytes with micronuclei induced by doxorubicin, probable due to the antioxidant properties of the flavonoids present in this plant.…”

<i>In vitro</i> Antibacterial and Chemical Properties of Essential Oils Including Native Plants from Brazil against Pathogenic and Resistant Bacteria

“…Baccharis dracunculifolia DC Asteraceae alecrim do campo is a producer of a variety of secondary metabolites medicinally recognised as antiulcer, anti-inflammatory and antibacterial 9 and their pharmacological properties such as antiviral, antifungal, anaesthetic, hypotensive, immunostimulatory and cytostatic activities were reported 10 .…”

Evaluation of the genotoxic and cytotoxic effects of crude extracts of Cordia ecalyculata and Echinodorus grandiflorus

“…The primary mechanism of drug action is likely to be through interaction with topoisomerase II. The effects of doxorubicin involve the production of free radicals, increase in DNA strand breakage, chromosome aberrations and increases in the micronucleus formation in vitro as well as in vivo (Aleisa et al, 2007;Gewirtz, 1999;Resende et al, 2007). For that, two short duration tests were undertaken: the Comet Assay (DNA damage) and the Micronucleus Test (chromosomal damage), which are accepted and recommended for certification in the pharmaceutical industry.…”