Evaluation of the genotoxic and cytotoxic effects of crude extracts of Cordia ecalyculata and Echinodorus grandiflorus

Silva, Cristiano José da; Bastos, Jairo Kenupp; Takahashi, Catarina Satie

doi:10.1016/j.jep.2009.10.015

Cited by 16 publications

(21 citation statements)

References 37 publications

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“…These results differ from those observed by da Silva et al (2010), who did not observe an anorectic effect of C. ecalyculata at doses of 500, 1000, and 2000 mg/kg. The difference in the anorectic effect observed between the sexes is likely related to differences in the hormonal environment, which leads to alteration of gene expression and physiological responses to drugs (Guidalini and Tufik, 2007), thereby justifying the need for in vivo testing separately between the sexes.…”

Section: Discussioncontrasting

confidence: 99%

“…The tests were conducted in both mouse and human cells, as recommended by the FDA, thus providing confidence in our results. Similar results were observed by da Silva et al (2010) at doses of 500, 1000, and 2000 mg/kg, who did not observe any genotoxic effects in cells from the peripheral blood of mice, as determined through a comet assay.…”

Section: Discussionsupporting

confidence: 87%

“…Moreover, Caparroz-Assef et al (2005) and da Silva et al (2010) showed that C. ecalyculata does not cause toxicity under chronic use.…”

Section: Discussionmentioning

confidence: 99%

“…), popularly known as "porangaba", "buggy tea", or "coffee bush", is a shrub with a height of 8-10 m and a diameter of 30-40 cm belonging to the family Boraginaceae that is distributed throughout the Brazilian territory, and is also found in the rainforests of Argentina and Paraguay (Menghini et al, 2008;da Silva et al, 2010). Its extract is marketed in Brazil and internationally under the name Pholia magra and has diuretic activity, leading to appetite suppression and weight reduction (Menghini et al, 2008;da Silva et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Mutagenic potential of Cordia ecalyculata alone and in association with Spirulina maxima for their evaluation as candidate anti-obesity drugs

Araldi¹,

Rechiutti²,

Mendes³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Obesity is one of the most important nutritional disorders, and can be currently considered as an epidemic. Although there are few weight reduction drugs available on the market, some new drug candidates have been proposed, including Cordia ecalyculata, a Brazilian plant with anorectic properties, and Spirulina maxima, a cyanobacterium with antioxidant and anti-genotoxic activity. In this study, we evaluated the mutagenic potential of C. ecalyculata at doses of 150, 300, and 500 mg/kg alone and in association with S. maxima at doses of 75, 150, and 250 mg/kg, respectively, through an in vivo micronucleus test, using mice of both sexes, and an in vitro micronucleus test and comet assay, using human peripheral blood. For all tests, cyclophosphamide was used as a positive control. The results showed that treatment of 300 mg/kg C. ecalyculata and the combination treatment of 500 mg/kg C. ecalyculata with 250 mg/kg S. maxima resulted in anorectic effects. The mutagenic tests did not reveal any clastogenic or genotoxic activity for any treatment, indicating that these candidates could be marketed as weight-reduction drugs. Moreover, the drugs contain chemo-preventive substances that can protect against tumorigenesis, which has been associated with obesity.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 87%

“…Moreover, Caparroz-Assef et al (2005) and da Silva et al (2010) showed that C. ecalyculata does not cause toxicity under chronic use.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mutagenic potential of Cordia ecalyculata alone and in association with Spirulina maxima for their evaluation as candidate anti-obesity drugs

Araldi¹,

Rechiutti²,

Mendes³

et al. 2014

Genet. Mol. Res.

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“…In the peripheral blood, the extract demonstrated a weak clastogenic effect but did not show cytotoxic or clastogenic activity against PCEs in the bone marrow for the treatment of 24 h and 15 days. [203] Chloroform, ethyl acetate and methanol bark extract of C. monoica showed absence of any signs of toxicity after administration of 2000 mg/kg dose orally in rats. [186] The crude leaf extract of C. verbenacea showed low toxicity in rats, and the LD 50 value (131.6 mg/kg) was found to be a hundred times more than the ED 50 value (1.24 mg/kg).…”

Section: Toxicity Studiesmentioning

confidence: 99%

Traditional uses, phytochemistry and pharmacology of the medicinal species of the genus Cordia (Boraginaceae)

Oza

Kulkarni

2017

Journal of Pharmacy and Pharmacology

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Objectives Cordia (family Boraginaceae) is a genus of deciduous flowering trees or shrubs comprising more than 300 species distributed widely in the tropical regions. The aim of this review was to provide exhaustive scientific information on traditional uses, phytochemistry and pharmacological activities of the 36 important species with medicinal value from the genus Cordia, to divulge prospects for further research on its therapeutic potential. Key findings Leaves, fruit, bark and seed of a majority of the species were found to possess abundant ethnomedicinal value, but leaves were found to be used most frequently to treat many ailments such as respiratory disorders, stomach pain, wound, inflammation, myalgia, cough, dysentery and diarrhoea. The phytochemical investigation of 36 species resulted in isolation of 293 chemical constituents from various chemical classes. The crude extracts, fractions, essential oils and pure compounds isolated from various Cordia species were reported to have a varied range of pharmacological activities. Summary Many of the traditional uses of the genus Cordia were supported by the results obtained from pharmacological studies performed using various extracts or pure compounds. More attention should be given to the biological evaluation using pure phytochemicals and to identify the mechanism of actions and exploring this genus for new drug discovery.

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Medicinal plants and their potential use in the treatment of rheumatic diseases

Oliveira

Braga

Teixeira

2021

Inflammation and Natural Products

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Evaluation of the genotoxic and cytotoxic effects of crude extracts of Cordia ecalyculata and Echinodorus grandiflorus

Cited by 16 publications

References 37 publications

Mutagenic potential of Cordia ecalyculata alone and in association with Spirulina maxima for their evaluation as candidate anti-obesity drugs

Mutagenic potential of Cordia ecalyculata alone and in association with Spirulina maxima for their evaluation as candidate anti-obesity drugs

Traditional uses, phytochemistry and pharmacology of the medicinal species of the genus Cordia (Boraginaceae)

Medicinal plants and their potential use in the treatment of rheumatic diseases

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