Medicinal plants and their potential use in the treatment of rheumatic diseases

Oliveira, Diego Pinto de; Braga, Fernão Castro; Teixeira, Mauro M.

doi:10.1016/b978-0-12-819218-4.00014-6

Cited by 3 publications

(3 citation statements)

References 97 publications

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“…are important spices that are used for various purposes in different parts of the world. The genus Cinnamomum comprises approximately 250 species that are distributed in the Asian and Australian continents [10]. Among these, the C. zeylanicum and C. cassia are the prominent representatives of the genus Cinnamomum.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition of the Cinnamomum malabatrum Leaf Essential Oil and Analysis of Its Antioxidant, Enzyme Inhibitory and Antibacterial Activities

Kuttithodi¹,

Narayanankutty²,

Visakh

et al. 2023

Antibiotics

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Cinnamomum species are a group of plants belonging to the Lauraceae family. These plants are predominantly used as spices in various food preparations and other culinary purposes. Furthermore, these plants are attributed to having cosmetic and pharmacological potential. Cinnamomum malabatrum (Burm. f.) J. Presl is an underexplored plant in the Cinnamomum genus. The present study evaluated the chemical composition by a GC-MS analysis and antioxidant properties of the essential oil from C. malabatrum (CMEO). Further, the pharmacological effects were determined as radical quenching, enzyme inhibition and antibacterial activity. The results of the GC-MS analysis indicated the presence of 38.26 % of linalool and 12.43% of caryophyllene in the essential oil. Furthermore, the benzyl benzoate (9.60%), eugenol (8.75%), cinnamaldehyde (7.01%) and humulene (5.32%) were also present in the essential oil. The antioxidant activity was indicated by radical quenching properties, ferric-reducing potential and lipid peroxidation inhibition ex vivo. Further, the enzyme-inhibitory potential was confirmed against the enzymes involved in diabetes and diabetic complications. The results also indicated the antibacterial activity of these essential oils against different Gram-positive and Gram-negative bacteria. The disc diffusion method and minimum inhibitory concentration analysis revealed a higher antibacterial potential for C. malabatrum essential oil. Overall, the results identified the predominant chemical compounds of C. malabatrum essential oil and its biological and pharmacological effects.

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Section: Introductionmentioning

confidence: 99%

Chemical Composition of the Cinnamomum malabatrum Leaf Essential Oil and Analysis of Its Antioxidant, Enzyme Inhibitory and Antibacterial Activities

Kuttithodi¹,

Narayanankutty²,

Visakh

et al. 2023

Antibiotics

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“…and Schltdl.) Micheli and E. macrophyllus (Kunth) Micheli are used for medicinal purposes [7][8][9][10][11][12]. Ethnobotanical investigations and clinical trials indicate that E. grandiflorus leaves have anti-hypertensive, anti-inflammatory, diuretic, and anti-arthritic properties [7,[10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Although there are several anatomical studies on Alismataceae species [19] such as Echinodorus spp. [23,24], Helanthium tenellum [7], Alisma plantago [40], Echinodorus macrophyllus [41] and Sagittaria montevidensis [22], these studies do not provide details regarding the anatomy and ontogeny of the secretory structures called the "laticifer ducts" [1,11,14,[22][23][24] or secretory canals [41]. Histochemical studies on the composition of the secretion are also absent.…”

Section: Introductionmentioning

confidence: 99%

New Aspects of Secretory Structures in Five Alismataceae Species: Laticifers or Ducts?

Leme

Bento

Fabiano

et al. 2021

Plants

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The secretory structures of Alismataceae have been described as secretory ducts, laticifer ducts, laticifer canals or schizogenous ducts. However, these terms are not found in the specialized literature, and ontogenetic analyses for the exact classification of these structures are missing. Accordingly, more studies regarding the secretory structures of Alismataceae are necessary to establish homology in the family or in the order. Thus, the aim of this study was to describe the anatomy, ontogeny, distribution in the organs and exudate composition of the secretory structures present in five Alismataceae species in order to determine whether the family has laticifers or secretory ducts. Samples of leaves, flowers and floral apices were processed for anatomical and histochemical analyses by light microscopy. The analysis indicated the presence of anastomosing secretory ducts in all species, occurring in both leaves and flowers. The exudate contains lipids, alkaloids, proteins and polysaccharides, including mucilage. The secretory duct structure, distribution and exudate composition suggest a defense role against herbivory and in wound sealing. The presence of secretory ducts in all species analyzed indicates a probable synapomorphy for the family.

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Immunomodulating Botanicals: An Overview of the Bioactive Phytochemicals for the Management of Autoimmune Disorders

Thakkar,

Vora,

Buttar

et al. 2024

Botanicals and Natural Bioactives: Prevention and Treatment of Diseases

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Immunomodulation refers to the mechanism by which the response of the immune system is modified by the regulation of antibody synthesis, leading to either an increase or a decrease in its levels in the circulation and body organs. Owing to their immunomodulation and remedial benefits, a broad range of herbal remedies have been shown to be effective in the treatment of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, myasthenia gravis, and systemic lupus erythematosus. The ancient Indian system of Ayurveda and different other alternative therapeutic methods have acknowledged the potential benefits of herbal-based remedies to upregulate or suppress the immune response in the human body. The conventional pharmacotherapies used for the management of autoimmune ailments are documented to cause serious drug-induced adverse reactions (ADRs). Whereas, some phytotherapies have proven safe, reliable, and efficient alternatives for the existing drug regimens with lesser ADRs. For instance, Withania somnifera, Andrographis paniculate, Tinospora cordifolia, Glycyrrhiza glabra, and Berberis arista are a few herbs whose bioactive phytoconstituents have been reported to possess powerful immunomodulation properties. Based on their purported immunomodulatory mechanisms, they can be used for the management of autoimmune conditions. The focus of this review is to highlight the key inflammatory biomarkers such as TNF-α and interleukin 1, 6 involved in the distortion of the immune system in humans. Also, we will discuss the usefulness of animal models for understanding the underlying mechanisms of autoimmune disorders. In addition, we will describe the patents of phytomedicine formulations filed by different manufacturers for the management of autoimmune disorders, as well as futuristic opportunities that should be explored for discovering the therapeutic functions of alternate remedies for treating autoimmune diseases.

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Medicinal plants and their potential use in the treatment of rheumatic diseases

Cited by 3 publications

References 97 publications

Chemical Composition of the Cinnamomum malabatrum Leaf Essential Oil and Analysis of Its Antioxidant, Enzyme Inhibitory and Antibacterial Activities

Chemical Composition of the Cinnamomum malabatrum Leaf Essential Oil and Analysis of Its Antioxidant, Enzyme Inhibitory and Antibacterial Activities

New Aspects of Secretory Structures in Five Alismataceae Species: Laticifers or Ducts?

Immunomodulating Botanicals: An Overview of the Bioactive Phytochemicals for the Management of Autoimmune Disorders

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