Inhibition of endogenous glucose production accounts for hypoglycemic effect of Spergularia purpurea in streptozotocin mice

Eddouks, Mohamed; Jouad, Hassan; Maghrani, Mhamed; Lemhadri, A.; Burcelin, Rémy

doi:10.1078/094471103322331890

Cited by 94 publications

(58 citation statements)

References 24 publications

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“…We observed that birds kept in HS conditions had greater glucose level than hens kept in TN condition and dietary rosemary oil had a positive effect on blood glucose level. This finding indicates that the rosemary oil might be producing its hypoglycemic activity by a mechanism independent from insulin secretion by the inhibition of endogenous glucose production or the inhibition of intestinal glucose absorption [29,30] . In a previous study, it has been suggested that 50% ethanol extract of Rosmarinus officinalis, in part, due to intestinal α-glycosidase (AGc) inhibitory activity of its active compound might play a role in controlling dietary glucose uptake in the small intestinal track [31] .…”

Section: Discussionmentioning

confidence: 91%

The Effects of Dietary Rosemary (Rosmarinus officinalis L.) Oil Supplementation on Performance, Carcass Traits and Some Blood Parameters of Japanese Quail Under Heat Stressed Condition

Çiftçi¹,

Şimşek²,

Azman³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryIn this study, the effects of rosemary (Rosmarinus officinalis L.) oil supplementation to diet were investigated on performance, carcass traits and some blood parameters of Japanese quails exposed to a high ambient temperature of 34°C. A total of 180 fifteen-day-old quails were divided into 6 treatments consisting of 10 birds of 3 replicates. All groups were balanced according to initial live weight and gender. Birds were kept in wire cages in temperaturecontrolled room at either 22°C for 24 h/d (thermo neutral-TN) or 22°C for 16 h/d and 34°C (heat stress-HS) for 8 h/d (from 9:00 to 17:00) during the study. Trial was conducted as a 2x3 factorial arrangement. Birds were fed either a basal (control) diet (TN and HS) or the basal diet supplemented with 125 or 250 ppm of rosemary oil. The highest final live weight was observed in 250 ppm rosemary oil under the TN condition and the lowest was in control group of HS. HS condition affected negatively on quail live weight (P<0.05), but the effect of rosemary oil on this parameter was not significant (P>0.05). Live weight gain and feed intake were not significantly different among the treatment groups (P>0.05). Feed conversion ratio was better in rosemary oil groups than control groups in both environmental conditions (P<0.01). Heat stress deteriorated carcass yield (P<0.01). The highest hot and cold carcass yield (g/100 g of body weight) was observed in 250 ppm rosemary oil added group under the TN condition, but this difference did not significant. Birds kept in HS conditions had greater glucose level than hens kept in TN conditions (P<0.01). Rosemary oil decreased blood glucose level, especially in 250 ppm group of HS (P<0.05). Total, HDL, LDL cholesterol and triglyceride levels were not significantly different among the treatment groups (P>0.05). In conclusion, rosemary oil supplementation reduced the negative effects of heat stress. Rosemary oil could be considered as a potential natural feed additive, following further studies. Keywords ÖzetBu çalışmada, karma yeme ilave edilen biberiye (Rosmarinus officinalis L.) yağının yüksek çevre sıcaklığına (34°C) maruz bırakılan Japon bıldırcınlarında performans, karkas özellikleri ve bazı kan parametreleri üzerine etkileri araştırılmıştır. Toplam olarak 180 adet 15 günlük bıldırcın, her tekerrürde 10 bıldırcının bulunduğu 3 tekerrürlü 6 gruba ayrılmıştır. Tüm gruplar başlangıç canlı ağırlıkları ve cinsiyet bakımından dengelenmiştir. Bıldırcınlar, çalışma süresince sıcaklık kontrollü odalarda 22°C'de 24 saat/gün (termo nötral-TN) ve 22°C'de 16 saat/gün 34°C'de 8 saat/gün (9:00-17:00) (sıcaklık stresi-HS) tel kafeslerde barındırılmıştır. Deneme 2x3 faktöriyel deneme düzenine göre yapılmıştır. Bıldırcınlar temel yem (kontrol) (TN ve HS) ve temel yeme 125 ve 250 ppm biberiye yağı ilave edilen karma yemler ile beslenmiştir. En yüksek canlı ağırlık TN bölümünde 250 ppm biberiye yağı ile beslenen grupta, en düşük canlı ağırlık ise sıcaklık stresi uygulanan tarafta kontrol grubunda gözlenmiştir. Sıcaklık stresi (HS) bıldırc...

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Section: Discussionmentioning

confidence: 91%

The Effects of Dietary Rosemary (Rosmarinus officinalis L.) Oil Supplementation on Performance, Carcass Traits and Some Blood Parameters of Japanese Quail Under Heat Stressed Condition

Çiftçi¹,

Şimşek²,

Azman³

et al. 2013

Kafkas Univ Vet Fak Derg

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“…Another possible action site for both extracts to exert there hypoglycemic effect is in the gastrointestinal tract; the fiber of plants may also interfere with carbohydrate absorption; thus affecting blood glucose, by slowing the digestion of food and decreasing the rate of carbohydrate absorption and clearing the postprandial glucose load [27]. Therefore, the hypoglycemic activity of this extracts may be due to inhibition of hepatic glucose production and/or stimulation of glucose utilization by peripheral tissues, especially muscle and adipose tissues [28]. In addition, both extracts could also act as inhibitors of tubular renal glucose reabsorption.…”

Section: Resultsmentioning

confidence: 99%

Statistical Data Analysis Which Result From the Bio-Diagnosis and Bio-Treatment of Injured Rats With the Hyperlipidemia and Hyperglycemia Diseases

Abduallah¹,

Abd‐Alla²,

Ali³

et al. 2016

Asian J Pharm Clin Res

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Objective: This study in bioinformatics aims to investigate the potential effect of Ipomoea tricolor and Sophora tomentosa on liver function enzymes activity, serum lipid profile, oxidative stress biomarkers, and on blood glucose in high fat diet-induced hypercholesterolemia (HC) and STZ-induced hyperglycemia (HG) in rats.Methods: Blood glucose level, liver function enzymes, alanine aminotransferases and aspartate aminotransferases, alkaline phosphatase, and lactate dehydrogenase (LDH) were determined. Besides, lipid profile including total cholesterol (TC), triacylglycerol (TG), total lipid, and high-density lipoprotein-cholesterol was investigated. Moreover, oxidative stress biomarkers, lipid peroxide, and nitric oxide as well as non-enzymatic antioxidant, glutathione (GSH) were also examined in different therapeutic groups.Results: A significant increase in blood glucose level, liver function enzyme activities, LDH, lipid profile and oxidative stress markers, while significant decrease in LDH-C and GSH level in HC-HG induced rats compared to control one. A marked amelioration in all biochemical parameters under investigation on treatment of HC-HG rats with I. tricolor and S. tomentosa with different fluctuating percentages of improvement. Histopathological examination of liver and pancreas was also performed and declared HC-HG showed congestion in portal vessels and sinusoids with mild centrilobular hepatocyte degeneration, marked hepatocyte ballooning and hydropic degeneration, while HC-HG treated rats with I. tricolor and S. tomentosa showed normal lobular hepatic architecture with mild sinusoidal dilatation and congestion. On the other hand, a histological organization of pancreas of HC-HG rats showing disarrangement changes in pancreatic blood vessels and interlobular duct as well as disordered in acini. The treatment of HC-HG rats with I. tricolor and S. tomentosa showed enhancement in Langerhans cells and restore of most pancreatic tissue in comparison with standard drugs. Conclusion:The statistical results showed that each extract ameliorated high blood glucose level liver injury, HC and oxidative stress indicating relieving of oxidative damage associated with the complexity of HG and HC. These results demonstrated that these two plants extracts may be a candidate intelligent antioxidant, hypolipidemic, hypoglycemic, and hepatoprotective nutraceuticals which need further clinical investigation to be applied effectively to reduce perturbation in HC associated diabetes.

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“…Previously, we have reported that inhibition of endogenous glucose production accounts for the hypoglycaemic activity of Spergularia purpurea aqueous extract in streptozotocin-induced mice [17] . The liver plays a strategic role in the control of glucose homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Chamaemelum nobile L. Aqueous Extract Represses Endogenous Glucose Production and Improves Insulin Sensitivity in Streptozotocin-induced Diabetic Mice

Lemhadri¹,

Burcelin²,

Sulpice³

et al. 2007

American J. of Pharmacology and Toxicology

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The present study was undertaken in order to evaluate the possible mechanisms of action involved in the hypoglycaemic activity of the aqueous extract of Chamaemelum nobile (CN) (20 mg kg −1). This study was carried out in Multi Low-Dose Streptozotocin-induced (MLDS) diabetic mice. Hypoglycaemic effect of CN was studied after both single and repeated oral administration of CN aqueous extract (20 mg kg). Endogenous glucose production was estimated using primedcontinuous 3-3 H glucose infusion technique. While, euglycemic hyperinsulinemic glucose clamp technique was used to assess peripheral insulin sensitivity. Both single and repeated oral administration (s) of aqueous CN extract evoked a prominent hypoglycaemic activity in MLDS diabetic mice. In other hand, 3-3 H glucose infusion demonstrated that this hypoglycaemic activity was accompanied by a decrease in basal endogenous glucose production (EGP). EGP was lower in CS-treated group when compared to the control group, 15.5±0.5 vs 27.2±7.1 mg kg −1 min −1 (p<0.001) respectively. While, the metabolic clearance rate of glucose remains unchanged. In addition, we have demonstrated that CN treatment also improves insulin sensitivity in peripheral tissues, suggested by the observed higher levels of the glucose infusion rate. We can conclude that inhibition of basal endogenous glucose production and amelioration of insulin sensitivity in peripheral tissues account for the hypoglycaemic activity of aqueous CN extract in MLDS diabetic mice.

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Inhibition of endogenous glucose production accounts for hypoglycemic effect of Spergularia purpurea in streptozotocin mice

Cited by 94 publications

References 24 publications

The Effects of Dietary Rosemary (Rosmarinus officinalis L.) Oil Supplementation on Performance, Carcass Traits and Some Blood Parameters of Japanese Quail Under Heat Stressed Condition

The Effects of Dietary Rosemary (Rosmarinus officinalis L.) Oil Supplementation on Performance, Carcass Traits and Some Blood Parameters of Japanese Quail Under Heat Stressed Condition

Statistical Data Analysis Which Result From the Bio-Diagnosis and Bio-Treatment of Injured Rats With the Hyperlipidemia and Hyperglycemia Diseases

Chamaemelum nobile L. Aqueous Extract Represses Endogenous Glucose Production and Improves Insulin Sensitivity in Streptozotocin-induced Diabetic Mice

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