Inhibition of eosinophil migration by lactoferrin

Bournazou, Irini; Mackenzie, Karen J.; Duffin, Rodger; Rossi, Adriano G.; Gregory, Christopher D.

doi:10.1038/icb.2009.86

Cited by 79 publications

(66 citation statements)

References 30 publications

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“…Mast cells contribute to the induction and/or maintenance of eosinophilic inflammation by a variety of mechanisms, including IgE-dependent and IgE-independent processes (Pawankar et al, 2007). The recruitment of these mast cells to inflammatory sites occurs in response to chemotactic and activation signals (Bournazou et al, 2010). The intercellular adhesion molecule (ICAM)-1, a member of the immunoglobulin gene superfamily of adhesion molecules, is expressed on the surface of a variety of cells, including vascular endothelial cells, epithelial cells, alveolar macrophages, and fibroblasts (Calderon and Lockey, 1992;Guzman et al, 1994;Montefort et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Oh¹,

Ryu²,

Cha³

et al. 2012

TANG [HUMANITAS MEDICINE]

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Jeechool-Whan (JW) is a prescription of Ponciri Fructus Immaturus and Atractylodis Rhizoma Alba and improves the functions of the stomach and the spleen. Although it is said in Korean Medicine that the spleen and the stomach are the roots of the body's resistance, the meaning of 'improving the spleen and the stomach' is very comprehensive. Moreover, there are lots of drugs that are said to improve the spleen and the stomach, and the number of prescriptions using these drugs is huge. In this study, we focused on the new effect and mechanism of the JW on the ovalbumin (OVA)-induced allergic rhinitis (AR) model. The increased number of rubs and the increased levels of IgE and histamine in the OVA-sensitized mice were inhibited by JW administration. The balance of Th1/Th2 cytokine level was regulated by JW administration. The levels inflammatory proteins were decreased by JW administration in the nasal mucosa of the OVA-sensitized mice. Eosinophils and mast cells infiltration increased by OVAsensitization was also decreased in the JW-administered mice. In addition, JW inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, JW inhibited the receptor interacting protein-2, IκB kinase-β, nuclear factor-κB/Rel A, and caspase-1 activation. In conclusion, this study will be support the clear understanding of the concept of the spleen and the stomach in traditional Korean medicine as well as for a possibility of finding a cure for this AR in traditional medical treatments.

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Section: Introductionmentioning

confidence: 99%

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Oh¹,

Ryu²,

Cha³

et al. 2012

TANG [HUMANITAS MEDICINE]

View full text Add to dashboard Cite

show abstract

“…Mast cells contribute to the induction and/or maintenance of eosinophilic inflammation by a variety of mechanisms, including IgE-dependent and IgE-independent processes (Pawankar et al, 2007). The recruitment of these mast cells to inflammatory sites occurs in response to chemotactic and activation signals (Bournazou et al, 2010). Minimal persistent inflammation is a physiopathological phenomenon referring to the presence of an inflammatory cell infiltrate (eosinophils and neutrophils) associated with the expression of intercellular adhesion molecule-1 (ICAM-1) in the epithelial cells of the mucosa exposed to the allergen in the absence of clinical symptoms.…”

Section: Introductionmentioning

confidence: 99%

Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro

Oh¹,

Kim²,

Jeong³

2011

J Pharmacol Exp Ther

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Because imperatorin (IPT), the furanocoumarins exhibits antiinflammatory activity, we reasoned that IPT might modulate the allergic rhinitis (AR). The aim of this study was to analyze the regulation of AR by IPT. Here, we show the effect and mechanism of IPT in an ovalbumin (OVA)-induced AR model. The number of rubs after the OVA challenge in the OVA-sensitized mice was significantly higher than that in the OVA-unsensitized mice. The increased number of rubs was inhibited by the oral administration of IPT. The increased levels of IgE and histamine in the OVA-sensitized mice were reduced by IPT administration. The levels of interferon-␥ were enhanced, whereas the levels of interleukin (IL)-4 were reduced on the spleen tissue of the IPT-administered AR mice. Protein levels of IL-1␤, macrophage inflammatory protein-2, intercellular adhesion molecule-1, and cyclooxygenase-2 were reduced by IPT administration in the nasal mucosa of the OVA-sensitized mice. In the IPT-administered mice, the number of eosinophils and mast cells infiltration increased by OVA-sensitization were also decreased. In addition, IPT inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, the receptor-interacting protein 2 (RIP2), IB kinase (IKK)-␤, nuclear factor-B (NF-B)/ RelA, and caspase-1 activation were increased, but increased RIP2, IKK-␤, NF-B/RelA, and caspase-1 activation were inhibited by the treatment of IPT. In addition, IPT inhibited caspase-1 activity and IL-1␤ production in IgE-stimulated bone marrowderived mast cells. We can conclude that IPT exerts significant effects by regulating of caspase-1 activation in AR animal and in vitro models.

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“…Indeed, it was already described that a great amount of various infl ammatory mediators could be released during the active period of an allergic infl ammation even from a small area of the body (like rhinoconjunctivitis) causing a generalized and long-lasting activation of neutrophils (KALLENBACH et al, 1992;SZABÓ et al, 2000). LF released by activated neutrophils may mediate numerous compensatory effects to inhibit allergic infl ammations, decreasing mast cell degranulation, tryptase activity, eosinophils' migration, and promoting the Th1-type immune responses (ELROD et al, 1997;HE et al 2003;DE LA ROSA et al, 2008;BOURNAZOU et al, 2010). Our other fi nding, that IL-17 was more frequently detectable and its levels were higher (although not signifi cantly) both in the serum and breast milk of allergic mothers, supports the previous observation that some patients with pollen-induced allergic rhinitis may have high serum IL-17 levels outside of the pollen season (CIPRANDI et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

A Possible Role of Elevated Breast Milk Lactoferrin and the Cytokine IL-17 Levels in Predicting Early Allergy in Infants: A Pilot Study

et al. 2016

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In this study, we examined the relationship between levels of lactoferrin (LF) and IL-17 in human serum and breast milk and the development of allergy in children. LF and IL-17 levels were determined by ELISA in healthy (n=19) and allergic mothers (n=21) on the 5 th day after delivery. Two years later, information on breastfeeding and allergic outcomes was collected by questionnaires from parents of both groups and district child care nurses. Signifi cantly higher concentrations of LF were found in the breast milk of allergic mothers compared to the healthy controls. At 2 years of age, only those three infants became allergic from the atopic group in whose starting breast milk samples a very high LF level (306 μg mg -1 protein) or simultaneously elevated concentrations of LF and IL-17 were measured. These fi ndings indicate that the very early measurement of LF and IL-17 levels in the breast milk of allergic mothers may help to predict the allergy development in their infants.

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Inhibition of eosinophil migration by lactoferrin

Cited by 79 publications

References 30 publications

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro

A Possible Role of Elevated Breast Milk Lactoferrin and the Cytokine IL-17 Levels in Predicting Early Allergy in Infants: A Pilot Study

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