Inhibition of Experimental Dental Caries by Antibiotics

Fitzgerald, Robert J.

doi:10.1128/aac.1.4.296

Cited by 33 publications

(20 citation statements)

References 19 publications

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“…We selected serotype c, which is the most frequently isolated from humans (independently of age, country, or sampling site) (12), for our bactericidal studies. Various antibiotics which are active in vitro against Streptococcus mutans and other cariogenic gram-positive organisms have also been shown to reduce the development of dental caries in rats, when administered in food (9). However, there are few studies on the use of antibiotics for caries control in man (7,13,18).…”

Section: Discussionmentioning

confidence: 99%

In vitro activity of A-16686, a potential antiplaque agent

Pallanza¹,

Scotti²,

Beretta³

et al. 1984

Antimicrob Agents Chemother

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A-16686, a new glycoproteide antibiotic from Actinoplanes sp., was evaluated as a potential antiplaque agent in comparison with chlorhexidine, benzalkonium chloride, and cetylpyridinium chloride. A-16686 had good activity against gram-positive organisms associated with dental plaque (various streptococci, Streptococcus mutans in particular, lactobacilli, Actinomyces viscosus, and Actinomyces naeslundi); most of the strains tested were clinical isolates. It was bactericidal for streptococci (MBC/MIC ratio of <8 for 92% of the strains) and for growing cells of S. mutans briefly exposed to antibiotic (99.9% killing within 5 min of contact with 200 ,g of A-16686 per ml). It also inhibited the in vitro plaque formation by S. mutans and had good activity against preformed plaques. For most cases, its activity was comparable to those of chlorhexidine, benzalkonium chloride, and cetylpyridinium chloride. A-16686 appears to be a promising antiplaque agent because of the following attributes: narrow spectrum of activity, rapid bactericidal action, lack of selection of resistant mutants, absence of cross-resistance with clinicaDly used antibiotics, nonabsorption by oral route, good tolerability by the oral mucosa (rats and dogs), and physical characteristics (white powder, soluble in water).

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Section: Discussionmentioning

confidence: 99%

In vitro activity of A-16686, a potential antiplaque agent

Pallanza¹,

Scotti²,

Beretta³

et al. 1984

Antimicrob Agents Chemother

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“…The need for a nontoxic agent which had activ ity against Gram-positive organisms and which was not used for other medical problems was recognized. However, not many agents could fit the criteria for safe ness as outlined by Fitzgerald [1972], Re cently, a compound which closely fits those criteria as an ideal substance has been proposed. A food-grade lipid, glycer ol monolaurin (GML), has been shown to have antimicrobial properties, especially against Gram-positive organisms [Kahara et al, 1972].…”

Section: Introductionmentioning

confidence: 99%

Anticariogenicity of Dietary Glycerol Monolaurin in Rats

Lynch¹,

Schemmel²,

Kabara³

1983

Caries Res

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Compared to rats inoculated with Streptococcus mutans, non-inoculated rats did not have any buccal/lingual caries and S. mutans in the oral cavity. However, sulcal caries prevalence was similar in both groups of rats. In addition, experiments were conducted to evaluate the anticariogenic effect of glycerol monolaurin. Rats were fed the experimental diets for either 4 or 6 weeks and then killed to assess caries prevalence and microbial oral populations. Rats consuming a diet with 2% glycerol monolaurin had a range of 45–50, 14–30 and 19–22% fewer caries on buccal/lingual, proximal and sulcal surfaces, respectively, than control rats fed a diet with hydrogenated shortening. Caries prevalence was higher in mandibular than in maxillary teeth. The number of S. mutans CFUs ranged from 28 to 69% lower among rats fed glycerol monolaurin than those fed vegetable shortening.

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“…Also in this study, a reduction of caries was observed when the rats received a wide variety of other antibiotics. 81 In human studies, Löe et al observed that tetracycline, vancomycin and polymyxin mouthwashes reduced the formation of gingival plaque. 82 Among these antibiotics, the greatest reduction was observed with tetracycline mouthwashes.…”

Section: +mentioning

confidence: 99%

Dental caries is a preventable infectious disease

Balakrishnan

Simmonds

Tagg

2000

Australian Dental Journal

167

100

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Dental caries is the most common infectious disease affecting humans. The principal causative agents are a group of streptococcal species collectively referred to as the mutans streptococci of which Streptococcus mutans and Streptococcus sobrinus are the most important agents of human caries. This review outlines what is currently known about these ubiquitous pathogens and discusses novel methods for elimination of these bacteria from dental plaque.

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Inhibition of Experimental Dental Caries by Antibiotics

Cited by 33 publications

References 19 publications

In vitro activity of A-16686, a potential antiplaque agent

In vitro activity of A-16686, a potential antiplaque agent

Anticariogenicity of Dietary Glycerol Monolaurin in Rats

Dental caries is a preventable infectious disease

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