Inhibition of ferrous‐induced lipid peroxidation by pyrimido‐pyrimidine derivatives in human liver membranes

Cruz, J. P. De La; Carrasco, T.; Ortega, Gonzalo Garrigós; Cuesta, Felipe Sánchez de la

doi:10.1007/bf02536177

Cited by 93 publications

(39 citation statements)

References 14 publications

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“…Moreover, the elevated lipid peroxidation in diabetic male and female rats was significantly alleviated as a result of 4b treatment. This result was in consonance with that obtained by de la Cruz et al [10] who revealed that 3 pyrimido-pyrimidine derivatives inhibited lipid peroxidation in human liver membranes. It is noteworthy to recognize that in diabetes, protein glycation and glucose auto-oxidation can lead to the formation of free radicals and induction of lipid peroxidation in several organs [73].…”

Section: Parameters Groupssupporting

confidence: 92%

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Antidiabetic and Antioxidant Effects of Newly Synthesized Pyrimido[1,6-A] Pyrimidine Derivatives in Neonatal Streptozotocin-Induced Diabetic Rats

Ahmed¹,

Hussein²

2012

Med Chem

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Synthesis of some novel pyrimido[1,6-a]pyrimidine derivatives 4, 8 and 10 was described through the respective reactions of sodium salts of formyl ketones 1, 7 and 9 with 6-aminothiouracil. The characterization of the reaction products was confirmed by using the available elemental analysis and spectral data. One of these derivatives (4b), 1-thioxo-1,2,7,8,9,10-hexahydro-3H-pyrimido[1,6-a]quinazolin-3-one, was tested using sublethal dose level (10 mg/kg b. w./day for 3 weeks) and was found to have potent antihyperglycemic, antihyperlipidemic and antioxidant properties in neonatal streptozotocin-induced (n-STZ) diabetic male and female albino rats.

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Section: Parameters Groupssupporting

confidence: 92%

“…It was also reported that pyrimidopyrimidine derivatives inhibited lipid peroxidation in human and rat liver [10]. Here, an easy construction of some new and interesting pyrimidopyimidines, the ring systems that can be found in marine-derived natural products such as crambescidin [11] and batzelladine [12] alkaloids has been achieved.…”

Section: Introductionmentioning

confidence: 95%

Antidiabetic and Antioxidant Effects of Newly Synthesized Pyrimido[1,6-A] Pyrimidine Derivatives in Neonatal Streptozotocin-Induced Diabetic Rats

Ahmed¹,

Hussein²

2012

Med Chem

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“…Lipid peroxidation was determined by quantifying the reaction products with thiobarbituric acid (thiobarbituric acid-reactive substances, TBARS) under basal conditions and after induction with ferrous salts [17]. The fraction enriched in cell membranes was obtained from liver tissue according to the method of Whittaker [18].…”

Section: Oxidative Stress In Liver Tissuementioning

confidence: 99%

Effects of Silymarin MZ-80 on Hepatic Oxidative Stress in Rats with Biliary Obstruction

Correa¹,

Cruz²,

Gordillo³

et al. 2001

Pharmacology

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This study was designed to evaluate the effects of three pharmaceutical forms of silymarin (silymarin MZ-80, silybinin-β-cyclodextrin, and silybinin) on the liver oxidative status in vitro and after oral administration to rats with extrahepatic biliary obstruction (EBO) and sham-operated animals. We evaluated thiobarbituric acid-reactive substances (TBARS), glutathione (GSH + GSSG) and their related enzyme activities (GSH peroxidase, GSSG reductase and GSH transferase). All three compounds inhibited the in vitro production of TBARS (IC₅₀ 56–533 µmol/l). These compounds, mainly silymarin MZ-80, also increased GSH peroxidase and GSH transferase activities. In EBO rats we found increases in TBARS production which was inhibited by 50–70% after treatment. Glutathione was reduced by 55% and elevated by silymarin MZ-80. GSH transferase increased in the group given silymarin MZ-80. We conclude that all three derivatives of silymarin show a clear ability to reduce lipid peroxidation in the liver. Silymarin MZ-80 was the only compound that enhanced the glutathione antioxidant system.

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“…Various researcher reported pyrimido pyrimidine explore the antitumor 14 , antiviral 15 , antioxidant 16 , antifungal 17 and hepatoprotective activities 18 .…”

Section: Introductionmentioning

confidence: 99%

A convenient route for synthesis and antimicrobial evaluation of bis (diimino benzothiazolo pyrimido pyrimidines)

Kalyankar¹,

Ubale²,

Vartale³

2014

Orient J Chem

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Pyrimido pyrimidine and its derivatives are interesting class of nitrogen containing heterocyclic compounds which are widely found in bio-organic and medicinal chemistry with application in drug discovery. Pyrimido [4,5-d] ABSTRACTGuanidine hydrochloride (1) on treatment with bis(methylthio)methylene malononitrile (2) in N,N-dimethyl formamide (DMF) and catalytic amount of anhydrous potassium carbonate gives diimino pyrimido pyrimidine (3). The later were further reacted with various substituted 2-amino benzothiazoles (4) to gives bis (diimino benzothiazolo pyrimido pyrimidines) (5a-g). All these synthesized compounds were screened for their antimicrobial activity.

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Inhibition of ferrous‐induced lipid peroxidation by pyrimido‐pyrimidine derivatives in human liver membranes

Cited by 93 publications

References 14 publications

Antidiabetic and Antioxidant Effects of Newly Synthesized Pyrimido[1,6-A] Pyrimidine Derivatives in Neonatal Streptozotocin-Induced Diabetic Rats

Antidiabetic and Antioxidant Effects of Newly Synthesized Pyrimido[1,6-A] Pyrimidine Derivatives in Neonatal Streptozotocin-Induced Diabetic Rats

Effects of Silymarin MZ-80 on Hepatic Oxidative Stress in Rats with Biliary Obstruction

A convenient route for synthesis and antimicrobial evaluation of bis (diimino benzothiazolo pyrimido pyrimidines)

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