Inhibition of GLUT2 transporter by geraniol from <i>Cymbopogon martinii</i>: a novel treatment for diabetes mellitus in streptozotocin-induced diabetic rats

Kamble, Subodh A.; Ghadyale, Varsha Adhikrao; Patil, Rahul; Haldavnekar, Vivek S.; Arvindekar, Akalpita U.

doi:10.1111/jphp.13194

Cited by 15 publications

(13 citation statements)

References 25 publications

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“…Also, it has powerful antioxidant, anticancer, antimicrobial, and anti-inflammatory properties (Elguindy et al, 2018). It was shown to reduce hyperglycemia by boosting the activity of glucose-6-phosphate dehydrogenase in the tissues of the liver and kidney (Babukumar et al, 2017) or glucose transporter 2 in the diabetic rat (Kamble et al, 2020). It can also improve the metabolic disorder in rats caused by fructose overconsumption (Ibrahim et al, 2015).…”

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confidence: 99%

Geraniol ameliorates the progression of high fat‐diet/streptozotocin‐induced type 2 diabetes mellitus in rats via regulation of caspase‐3, Bcl‐2, and Bax expression

Azab

Mostafa

2022

Journal of Food Biochemistry

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Diabetes mellitus (DM) is rapidly overburdening the world's healthcare systems. In parallel to globalization, marked disparities in human attitudes and lifestyles have contributed to diabetes rates escalating (Hasan & Mohieldein, 2016). In 2019, the International Diabetes Federation stated that about 463 million adults (20-79 years) worldwide were affected by DM (Cuschieri & Grech, 2020).Insufficient insulin production and/or lack of insulin sensitivity may be causing diabetes. Also, a sequence of chronic metabolic

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confidence: 99%

Geraniol ameliorates the progression of high fat‐diet/streptozotocin‐induced type 2 diabetes mellitus in rats via regulation of caspase‐3, Bcl‐2, and Bax expression

Azab

Mostafa

2022

Journal of Food Biochemistry

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“…Also, geraniol has repeatedly been shown to have an antihyperglycemic impact by altering major carbohydrate metabolism enzymes [ 23 ]. It was established that geraniol's antihyperglycemic activity against diabetes complications is mediated by decreasing gluconeogenic enzymes and glucose transporter-2 (GLUT2) [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Amelioration of Age-Related Multiple Neuronal Impairments and Inflammation in High-Fat Diet-Fed Rats: The Prospective Multitargets of Geraniol

Azab¹,

Abdulmalek

2022

Oxidative Medicine and Cellular Longevity

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Neuroinflammation is documented to alter brain function as a consequence of metabolic changes linked with a high-fat diet (HFD). The primary target of this study is to see how geraniol is effective in manipulating age- and diet-associated multiple toxicity and neuroinflammation in HFD-fed rats. Sixty-four adult male Wistar rats were partitioned into two groups: Group 1 (untreated normal young and aged rats) and Group 2 (HFD-fed young and aged rats) that received HFD for 16 weeks before being orally treated with geraniol or chromax for eight weeks. The results revealed a dropping in proinflammatory cytokines (TNF-α and IL-6) and leptin while boosting adiponectin in geraniol-supplemented rats. The liver, kidney, and lipid profiles were improved in geraniol-HFD-treated groups. HFD-induced brain insulin resistance decreased insulin clearance and insulin-degrading enzyme (IDE) levels significantly after geraniol supplementation. Geraniol suppressed acetylcholinesterase (AChE) activity and alleviated oxidative stress by boosting neuronal reduced glutathione (GSH), catalase (CAT), glutathione-S-transferase (GST), and superoxide dismutase (SOD) activities. It lowered malondialdehyde concentration (TBARS), nitric oxide (NO), and xanthine oxidase (XO) and restored the structural damage to the brain tissue caused by HFD. Compared with model rats, geraniol boosted learning and memory function and ameliorated the inflammation status in the brain by lowering the protein levels of IL-1β, iNOS, NF-κBp65, and COX-2. In addition, the expression levels of inflammation-related genes (MCP-1, TNF-α, IL-6, IL-1β, and IDO-1) were lessened significantly. Remarkably, the supplementation of geraniol reversed the oxidative and inflammation changes associated with aging. It affected the redox status of young rats. In conclusion, our results exhibit the effectiveness of dietary geraniol supplementation in modifying age-related neuroinflammation and oxidative stress in rats and triggering off the use of geraniol as a noninvasive natural compound for controlling age- and diet-associated neuronal impairments and toxicity.

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“…W. Watson ( Ganjewala and Luthra, 2009 ), and Cymbopogon martini (Roxb.) W. Watson ( Kamble et al, 2020 ).…”

Section: Natural Products Against Sars-cov-2: Computational To Preclinical Studiesmentioning

confidence: 99%

Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources

Singla

Chopra

et al. 2021

Front. Pharmacol.

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Background: The world has been unprecedentedly hit by a global pandemic which broke the record of deadly pandemics that faced humanity ever since its existence. Even kids are well-versed in the terminologies and basics of the SARS-CoV-2 virus and COVID-19 now. The vaccination program has been successfully launched in various countries, given that the huge global population of concern is still far behind to be vaccinated. Furthermore, the scarcity of any potential drug against the COVID-19-causing virus forces scientists and clinicians to search for alternative and complementary medicines on a war-footing basis.Aims and Objectives: The present review aims to cover and analyze the etiology and epidemiology of COVID-19, the role of intestinal microbiota and pro-inflammatory markers, and most importantly, the natural products to combat this deadly SARS-CoV-2 virus.Methods: A primary literature search was conducted through PubMed and Google Scholar using relevant keywords. Natural products were searched from January 2020 to November 2020. No timeline limit has been imposed on the search for the biological sources of those phytochemicals. Interactive mapping has been done to analyze the multi-modal and multi-target sources.Results and Discussion: The intestinal microbiota and the pro-inflammatory markers that can serve the prognosis, diagnosis, and treatment of COVID-19 were discussed. The literature search resulted in yielding 70 phytochemicals and ten polyherbal formulations which were scientifically analyzed against the SARS-CoV-2 virus and its targets and found significant. Retrospective analyses led to provide information about 165 biological sources that can also be screened if not done earlier.Conclusion: The interactive analysis mapping of biological sources with phytochemicals and targets as well as that of phytochemical class with phytochemicals and COVID-19 targets yielded insights into the multitarget and multimodal evidence-based complementary medicines.

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Inhibition of GLUT2 transporter by geraniol from Cymbopogon martinii: a novel treatment for diabetes mellitus in streptozotocin-induced diabetic rats

Cited by 15 publications

References 25 publications

Geraniol ameliorates the progression of high fat‐diet/streptozotocin‐induced type 2 diabetes mellitus in rats via regulation of caspase‐3, Bcl‐2, and Bax expression

Geraniol ameliorates the progression of high fat‐diet/streptozotocin‐induced type 2 diabetes mellitus in rats via regulation of caspase‐3, Bcl‐2, and Bax expression

Amelioration of Age-Related Multiple Neuronal Impairments and Inflammation in High-Fat Diet-Fed Rats: The Prospective Multitargets of Geraniol

Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources

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