Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation

Chen, Xiaoqing; Qiao, Haishi; Liu, Taixiang; Yang, Ziying; Xu, Lanfang; Yang, Xu; Ge, Hui; Tan, Renxiang; Li, Erguang

doi:10.1016/j.antiviral.2012.05.001

Cited by 57 publications

(47 citation statements)

References 47 publications

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“…Resveratrol and several oligomeric stilbenoids have been found to possess potent activity against HSV. 32) Here the anti-herpetic activities of 6 stilbene derivatives from Mulberry leaves were tested, and five of them showed potent antiviral effect in vitro. Among of them, Kuwanon X was chosen to determine the antiviral mechanisms due to its excellent anti-HSV action.…”

Section: Discussionmentioning

confidence: 99%

Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-κB Deactivated Properties

Shen

Zhang

et al. 2016

Biological & Pharmaceutical Bulletin

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Six stilbene derivatives isolated from Mulberry leaves including Kuwanon X, Mulberrofuran C, Mulberrofuran G, Moracin C, Moracin M 3′-O-b-glucopyranoside and Moracin M were found to have antiviral effects against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) at different potencies except for Mulberrofuran G. Kuwanon X exhibited the greatest activity against HSV-1 15577 and clinical strains and HSV-2 strain 333 with IC 50 values of 2.2, 1.5 and 2.5 µg/mL, respectively. Further study revealed that Kuwanon X did not inactivate cell-free HSV-1 particles, but inhibited cellular adsorption and penetration of HSV-1 viral particles. Following viral penetration, Kuwanon X reduced the expression of HSV-1 IE and L genes, and decreased the synthesis of HSV-1 DNA. Furthermore, it was demonstrated that Kuwanon X inhibited the HSV-1-induced nuclear factor (NF)-κB activation through blocking the nuclear translocation and DNA binding of NF-κB. These results suggest that Kuwanon X exerts anti-HSV activity through multiple modes and could be a potential candidate for the therapy of HSV infection.Key words anti-herpes simplex virus (HSV) activity; Kuwanon X; penetration; gene expression; nuclear factor (NF)-κB; Mulberry Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are prevalent pathogens worldwide. HSV-1 is the main cause of orofacial herpes, cephalitis, corneal blindness, and several disorders of the peripheral nervous system; HSV-2 is usually associated with recurrent genital herpes, meningoencephalitis in neonates and meningitis in adults. Both HSV-1 and HSV-2 can cause latent infections in the neurons system, and then cause lesions at or near the point of entry into the body when they are reactivated.1,2) Recently, it was reported that HSV infections can increase the transmission of human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type 1 (HTLV-1).3) During the productive infection, a successful HSV replication cycle is dependent on the completion of several steps, including α (immediate-early or IE), β (early or E), γ (late or L) genes and unpaired DNA replication based on sequential expression. The IE genes, such as UL54, encode transacting regulators of gene expression. The E genes, including UL52, are involved in viral DNA synthesis and nucleotide metabolism. The L genes, mainly encode structural proteins, e.g. ICP5 encoding the main capsid protein VP5. 4)The standard therapy for HSV infections are nucleoside analogues, such as acyclovir (ACV) and penciclovir. However, the emergence of HSV strains resistant to ACV remains an important clinical concern in immunocompromised individuals.5) Therefore, it is necessary to develop new antiherpetic agents with mechanisms of action different from that of nucleoside analogues.Mulberry (Morusalba L.) is widely cultivated in several Asian countries. Its leaves, fruits, twigs and root barks have long been used in Chinese medicine to reduce fever, maintain liver health, improve eyesight and lower blood pressure. Besides, Mulberry leaf is commonly...

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Section: Discussionmentioning

confidence: 99%

Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-κB Deactivated Properties

Shen

Zhang

et al. 2016

Biological & Pharmaceutical Bulletin

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“…We also defined that c-Jun was exclusively activated by viral infection through JNK. Unexpectedly, BHV-1 infection-activated MAPK pathways was not through a reactive oxygen species (ROS)-dependent mechanism, though ROS is widely reported to be an activator of MAPK pathways during numerous virus infections, such as by HSV-1 [17, 18]. These studies partially address the importance of MAPK pathways in BHV-1 infection induced inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

The activation of p38MAPK and JNK pathways in bovine herpesvirus 1 infected MDBK cells

Zhu

Yuan

Huang

et al. 2016

Vet Res

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We have shown previously that BHV-1 infection activates Erk1/2 signaling. Here, we show that BHV-1 provoked an early-stage transient and late-stage sustained activation of JNK, p38MAPK and c-Jun signaling in MDBK cells. C-Jun phosphorylation was dependent on JNK. These early events were partially due to the viral entry process. Unexpectedly, reactive oxygen species were not involved in the later activation phase. Interestingly, only activated JNK facilitated the viral multiplication identified through both chemical inhibitor and siRNA. Collectively, this study provides insight into our understanding of early stages of BHV-1 infection.

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“…Vaticanol E (36), pauciflorol B (33), hopeaphenol A (43), pauciflorol C (45), vaticaffinol (49) and hemsleyanol D (51) demonstrated antiviral activity against HSV-1 with IC 50 values 12.1 ± 0.5, 16.7 ± 0.5, 17.3 ± 0.5, 24.1 ± 0.6, 17.9 ± 0.3 and 9.1 ± 0.5 μM as well as HSV-2 with IC 50 values 4.5 ± 0.1, 3.2 ± 0.5, 3.7 ± 0.2, 3.3 ± 0.1, 3.2 ± 0.3 and 3.8 ± 0.2 μM respectively [85]. Vaticanols A (35), B (54), E (36) and G (40) possessed antifeedant activity against subterranean termite, Reticulitermes speratus [86].…”

Section: Other Activitiesmentioning

confidence: 98%

Oligostilbenoids from Vatica Species and Bioactivities

Kamarozaman

Rajab²,

Latip³

2014

Recent Trends in Physics of Material Science and Technology

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Reactive species (RS) which are generated from the pollution, deep fried and spicy foods, leakage of electrons from mitochondrial electron transport chains etc. may result in an oxidative damage in the body. The oxidative damage may lead to various diseases such as Alzheimer, atherosclerosis and cancer. In order to prevent such diseases, antioxidants play important roles in reducing the powerful oxidizing agents. Vatica species that belongs to the family of Dipterocarpaceae has been widely known to contain abundant source of oligostilbenoids which demonstrated interesting result in biological activities such as anticancer and antioxidant. This may lead to a development of drugs as well as natural antioxidants. In this chapter, we are highlighting the oligostilbenoids isolated from Vatica species from various researcher as well as the biological activities.

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Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation

Cited by 57 publications

References 47 publications

Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-κB Deactivated Properties

Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-κB Deactivated Properties

The activation of p38MAPK and JNK pathways in bovine herpesvirus 1 infected MDBK cells

Oligostilbenoids from Vatica Species and Bioactivities

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