Inhibition of histamine mediated responses by<i>Mirabilis jalapa</i>: confirming traditional claims made about antiallergic and antiasthmatic activity

Maxia, Andrea; Sanna, Cinzia; Salve, Balu; Kasture, Ameya; Kasture, Sanjay

doi:10.1080/14786410802632804

Cited by 12 publications

(6 citation statements)

References 7 publications

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“…The present study revealed that parenteral administration of milk increased the total leukocyte count that was restored by pre-treatment with DB, indicating adaptogenic activity of ethanolic extract of DB. These findings are in congruence with the observations of Maxia et al [13] Compound 48/80 is a mixed polymer of phenethylamine cross-linked by formaldehyde, which initiates the activation of signal transduction pathway leading to histamine release from mast cells. [14] Compound 48/80 can be used to study the mechanistic pathway for allergy and anaphylaxis.…”

Section: Discussionsupporting

confidence: 93%

Anti-allergic and anti-anaphylactic activities of Dolichos biflorus

Suralkar¹,

Kasture²

2013

Int J Green Pharm

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Experimental AnimalsWistar rats (150-200 g) and Swiss Albino mice (20-25 g) of either sex were purchased from the National Toxicology Center, Pune. They were housed in groups of five under standard laboratory conditions of temperature (25 ± 2°C) and 12 h lightdark cycle. Animals were provided standard pellet diet (Amrut Laboratory animal feed, Sangli-Maharashtra) and water ad libitum. The distribution of animals in the groups, the sequence of trials and the treatment allotted to each group were randomized throughout the experiment. Laboratory animal handling and experimental procedures were performed in accordance with the guidelines of CPCSEA, and the experimental protocol was approved by Institutional Animal Ethics Committee (198/99/CPCSEA).Background: The seeds of Dolichos biflorus (DB) have been traditionally used in the treatment of cough and asthma. Aim: Based on the traditional claim, the present study was planned to evaluate the anti-allergic and anti-anaphylactic activities of DB. Materials and Methods: The ethanolic extract of the seeds of DB was prepared by cold maceration process. DB was subjected to phytochemical screening, acute toxicity studies, mast cell-stabilizing activity using compound 48/80 and anti-allergic activity using milk-induced leukocytosis and eosinophilia and passive paw anaphylaxis. Statistical Analysis: Statistical analysis was done by using one-way analysis of variance followed by Dunnett's test. Results: The phytochemical investigation showed presence of proteins, flavonoids and glycosides. DB extract inhibited milk-induced leukocytosis and eosinophilia and also the compound 48/80 induced mast cell degranulation. DB extract significantly reduced passive paw anaphylaxis in a dose-dependent manner. Conclusion:The results demonstrated that DB extract possesses anti-allergic and anti-anaphylactic potentials that might be useful in the management of asthma.

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Section: Discussionsupporting

confidence: 93%

Anti-allergic and anti-anaphylactic activities of Dolichos biflorus

Suralkar¹,

Kasture²

2013

Int J Green Pharm

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“…The extract (0.5 ml of 100 mg/ml) inhibited histamine-induced Guinea pig tracheal chain contractions non-competitively. The extract (100 or 200 mg/kg, ip) also inhibited milk-induced eosinophilia, albumin-induced paw oedema and protected mast cells against clonidineinduced granulation [75].…”

Section: Antihistaminic and Immune-modulatory Effectsmentioning

confidence: 94%

Chemical constituents and pharmacological activities of Mirabilis jalapa- A review

Al-Snafi¹,

Talab²,

Jabbar³

et al. 2021

Int. J. Biol. Pharm. Sci. Arch.

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Mirabilis jalapa was used traditionally in the treatment of kidney infections, as diuretic, tonic, cathartic, purgative and emetic. The phytochemical screening of the extracts of the leaves and stems of the Mirabilis jalaparevealed the presence of tannins, alkaloids, flavonoids, phenolic compounds, carbohydrates, terpenes, glycosides, saponins, protein, cardiac glycosides, steroids and emodin. The previous pharmacological studies revealed that Mirabilis jalapa possessed wide range of pharmacological and therapeutic effects included antimicrobial, antiparasitic, dermatological, anticancer, anti-inflammatory, analgesic, antidiabetic, antihistaminic, immune-modulatory, antispasmodic and many other pharmacological effects. The chemical constituents, nutritional, pharmacological and therapeutic effects ofMirabilis jalapawere discussed in the current review.

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“…inhibited milk-induced eosinophilia, albumin-induced paw edema and protected mast cells against clonidine-induced granulation justifying the folkloric use of M. jalapa in the treatment of allergic diseases and asthma. [48]…”

Section: Herbal Drugs For Skin Diseasesmentioning

confidence: 99%

Plants used to treat skin diseases

Tabassum¹,

Hamdani²

2014

Phcog Rev

202

108

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Skin diseases are numerous and a frequently occurring health problem affecting all ages from the neonates to the elderly and cause harm in number of ways. Maintaining healthy skin is important for a healthy body. Many people may develop skin diseases that affect the skin, including cancer, herpes and cellulitis. Some wild plants and their parts are frequently used to treat these diseases. The use of plants is as old as the mankind. Natural treatment is cheap and claimed to be safe. It is also suitable raw material for production of new synthetic agents. A review of some plants for the treatment of skin diseases is provided that summarizes the recent technical advancements that have taken place in this area during the past 17 years.

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Inhibition of histamine mediated responses byMirabilis jalapa: confirming traditional claims made about antiallergic and antiasthmatic activity

Cited by 12 publications

References 7 publications

Anti-allergic and anti-anaphylactic activities of Dolichos biflorus

Anti-allergic and anti-anaphylactic activities of Dolichos biflorus

Chemical constituents and pharmacological activities of Mirabilis jalapa- A review

Plants used to treat skin diseases

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