“…Although the mechanism responsible for the inhibition described above remains unclear, accumulating studies have shown that genistein has multiple antitumour functions. Those include inhibition of tyrosine kinase activity (Akiyama et al, 1987), topoisomerase II (Okura et al, 1988) and steroid metabolizing enzymes such as 17b-hydroxysteroid oxidoreductase (Mäkelä et al, 1998), P-450 aromatase (Adlercreutz et al, 1993) and 5-a reductase (Evans et al, 1995), induction of differentiation (Record et al, 1997), G2/M arrest, induction of p21 WAF1/CIP1 and apoptosis (Shao et al, 1998). With regard to angiogenesis, genistein blocks the expression of VEGF induced by hypoxia by inhibiting src tyrosine kinase in some cancer cell lines (Mukhopadhyay et al, 1995).…”