Inhibition of Interferon Induction in Mice by Mycoplasmas and Mycoplasmal Fractions

Pathogenicity of influenza virus.

“…Commensals may influence mucosal attack by influenza virus. Fungi, bacteria, and their products induce interferon (34); mycoplasma can damage ciliated epithelium (237) and prevent interferon induction (42); and Haemophilus influenzae, a persistent colonizer of chronic bronchitics (243), produces a substance which destroys the ciliated epithelium of human fetal on September 3, 2020 by guest http://mmbr.asm.org/ Downloaded from trachea (52).To determine whether commensals influence the primary stages of influenza, experiments should be conducted as for bacterial infections and infection of pigeons with Venezuelan equine encephalitis virus (34,216). Volunteers, ferrets, or mice could be treated systemically or locally with antibiotics to remove commensals from the upper respiratory tract before aerosol inoculation to observe the effect on infection by virulent and attenuated strains of virus.…”

Toxicology: Complications Caused by Murine Viruses and Mycoplasmas

“…Sendai and MHV are interferon producers (15,17) and it has been suggested (28) that infections by either or both may be accompanied by this effect. M. pulmonis inhibits interferon induction (30). This could be a complicating factor if the test material given to an infected animal is an interferon inducer.…”

Pathogenicity of influenza virus

“…Commensals may influence mucosal attack by influenza virus. Fungi, bacteria, and their products induce interferon (34); mycoplasma can damage ciliated epithelium (237) and prevent interferon induction (42); and Haemophilus influenzae, a persistent colonizer of chronic bronchitics (243), produces a substance which destroys the ciliated epithelium of human fetal on December 13, 2020 by guest http://mmbr.asm.org/ Downloaded from trachea (52).To determine whether commensals influence the primary stages of influenza, experiments should be conducted as for bacterial infections and infection of pigeons with Venezuelan equine encephalitis virus (34,216). Volunteers, ferrets, or mice could be treated systemically or locally with antibiotics to remove commensals from the upper respiratory tract before aerosol inoculation to observe the effect on infection by virulent and attenuated strains of virus.…”