Inhibition of Intraocular Fibrin Formation Following Infusion of Low-Molecular-Weight Heparin During Vitrectomy

Iverson, Deborah A.; Katsura, Hiroshi; Hartzer, Michael K.; Blumenkranz, Mark S.

doi:10.1001/archopht.1991.01080030107048

Cited by 61 publications

(47 citation statements)

References 25 publications

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“…Histopathological assessment of the sections from Labrador Retriever revealed a fibro-cellular membrane formation containing RPE cells, ciliary epithelial cells and glial cells on detached retina [60]. It is considered that this PVR model is unique spontaneous PVR model similar to the human PVR.…”

Section: Proliferative Vitreoretinopathy (Pvr)mentioning

confidence: 80%

“…Dispase selectively disrupts type 4 collagen and fibronectin in the structure of the basement membrane which plays acritical role in the continuity of RPE cell layer. In recent studies, it was shown that an effective dose of dispase is 0.05 -0.07 U and that average duration is 8 -10 weeks for PVR development [58,59].Histopathological assessment of the sections from Labrador Retriever revealed a fibro-cellular membrane formation containing RPE cells, ciliary epithelial cells and glial cells on detached retina [60]. It is considered that this PVR model is unique spontaneous PVR model similar to the human PVR.…”

mentioning

confidence: 92%

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Experimental Animal Models for Retinal and Choroidal Diseases

Turgut

Karanfil

2017

AOVS

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Experimental animal models have critical importance for the recognition and the management of various retinal and choroidal diseases. To date, they were described for the induction of melanoma and neovascularization of choroid, degenerations, and detachment in the retina, proliferative vitreoretinopathy, diabetic and hypertensive retinopathy, pre-retinal neovascularization, central serous chorioretinopathy, retinopathy of prematurity (ROP) or O 2 induced retinopathy (OIR) and retinoblastoma. The aim of this review is to provide an overview of experimental animal models for retinal and choroidal diseases. To know the most favorite models and animals for these diseases will provide many utilities to the researchers in their experimental studies and thesis. Keywords: Experimental Animal Models for Retinal and Choroidal Diseases 2/10Copyright: ©2017 Turgut et al.primate laser-induced CNV models in rhesus and cynomolgus monkeys have been choiced for preclinical evaluation of n-AMD treatment options [19,21,22,26]. Except for the LFC induced CNV, the sub-retinal NV has been formed in transgenic mice through the increased expression of vascular endothelial growth factor in the retina [23]. Retinal Detachment (RD)The animal RD models are important in the evaluation of the pathogenesis of the disease and new treatment methods in . Many studies have used the mouse as a model to study retinal detachment/reattachment. Mouse eye is a good model for the experimental eye diseases because its manupilation is easy [41][42][43][44]. In animal RD models, manual peeling off the neuroretina from the retina pigment epithelium (RPE) and the subretinal injection of saline, balanced salt solution, phosphatebuffered saline (PBS), hyaluronate or RPE cells have been used to establish an experimental RD in rodent eyes and provide the pathologic features of human . The subretinal injection of sodium hyaluronate has some advantages such as no known ocular toxicity and the long-duration of RD compared to others. The subretinal injection of sodium hyaluronate may performed with a trans-vitreal or a trans-scleral way with the observation of the fundus [28,29,[32][33][34]40]. In the trans-vitreal method, a sub-retinal injector is introduced into the vitreous cavity, a peripheral retinotomy is created, and the sodium hyaluronate is injected into the subretinal space. In this method, two retinal tears are created to increase the risk of retinal hemorrhage. Subretinal hemorrhage or hemorrhage entered underneath the retina is toxic for photoreceptor cells through retinal hypoxia and metabolic impairment due toits diffusion barrier effect, and toxicity due to iron in blood in the detached retina. This induces retinal degeneration and RD [28,29,[32][33][34]40].In trans-scleral method, a 30 G needle with a syringe containing sodium hyaluronate is inserted into the subretinal space through the conjunctiva, sclera, choroid, and RPE following reduction of intraocular pressure (IOP) with an anterior chamber parasenthesis. The sodium hyaluronate is ...

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Section: Proliferative Vitreoretinopathy (Pvr)mentioning

confidence: 80%

mentioning

confidence: 92%

Experimental Animal Models for Retinal and Choroidal Diseases

Turgut

Karanfil

2017

AOVS

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“…11 Iverson and coauthors demonstrated that an infusion of low molecular weight heparin inhibits the development of fibrin after lensectomy, vitrectomy and retinotomy in rabbits. 13 Heparin has been shown to induce apoptosis in human peripheral neutrophils which may help in explaining its anti-inflammatory effect.…”

Section: Aimmentioning

confidence: 99%

Low molecular weight heparin in intraocular infusion in high risk group cataract surgery - minimizes inflammatory reaction and prevents posterior capsular opacification

Nema¹

2018

jmscr

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“…61 Low molecular weight heparin (LMWH) is a multipotential drug useful in the treatment of PVR. LMWH has been shown to reduce postoperative fibrin following vitrectomy 62 and to have less haematological complications compared with non-fractionated heparin. 63 Heparin binds to fibronectin and to a wide range of growth factors including acidic and basic fibroblast growth factors and platelet derived growth factors.…”

Section: Adjuvant Therapy For the Treatment Of Pvrmentioning

confidence: 99%

“…64 Eye: Cambridge Ophthalmological Symposium Animal work has shown that LMWH is effective in reducing the rate of tractional retinal detachment and produced no toxic effects in the rabbit eye when infused using a dose of 5 IU/ml. 62 Only two large prospective trials have so far been reported on the use of adjuvant therapy to treat PVR. The first used daunomycin.…”

Section: Adjuvant Therapy For the Treatment Of Pvrmentioning

confidence: 99%

Simple retinal detachments: identifying the at-risk case

Asaria

Gregor

2002

Eye

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The success rate of retinal reattachment surgery has now reached over 90%. The major cause of failure is attributable to the development of proliferative vitreoretinopathy (PVR). It is a complex process comprised of events that are similar to those of the wound healing response with inflammation, migration and proliferation of a variety of cells. These membranes can exert traction and reopen previously closed retinal breaks, create new breaks, and distort or obscure the macula.In the early part of this century the success rate of retinal reattachment surgery was virtually nil and it was not until a better understanding of the pathophysiology of retinal detachment was gained that the success rate improved. It was Gonin who emphasised the relationship between vitreous detachment and traction resulting in retinal tears that led to treatment aimed at closing retinal breaks.To increase even further the final success rate in the treatment of 'simple retinal detachments' a better understanding of the risk factors for PVR is needed in patients presenting with acute retinal detachments. Such risk factors can be broadly divided under the headings of preoperative risk factors, best surgical management and possibly adjuvant therapy.

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Inhibition of Intraocular Fibrin Formation Following Infusion of Low-Molecular-Weight Heparin During Vitrectomy

Cited by 61 publications

References 25 publications

Experimental Animal Models for Retinal and Choroidal Diseases

Experimental Animal Models for Retinal and Choroidal Diseases

Low molecular weight heparin in intraocular infusion in high risk group cataract surgery - minimizes inflammatory reaction and prevents posterior capsular opacification

Simple retinal detachments: identifying the at-risk case

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