Inhibition of iron absorption prolongs the life span of Drosophila

Massie, Harold R.; Aiello, Valerie R.; Williams, T. R.

doi:10.1016/0047-6374(93)90001-8

Cited by 55 publications

(39 citation statements)

References 22 publications

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“…The authors also found that R. damascena could improve D. melanogaster resistance to paraquat and H 2 O 2 . The same study also showed that the natural product, black tea (Camellia sinensis), blocked the age-dependent accumulation of iron, improved iron tolerance, and extended the lifespan of D. melanogaster (MASSIE et al 1993). Enhanced stress resistance is likely to benefit from the upregulated expression of hsps.…”

Section: Discussionmentioning

confidence: 74%

Changes in the expression of four heat shock proteins during the aging process in Brachionus calyciflorus (rotifera)

Yang

Dong

et al. 2014

Cell Stress and Chaperones

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Heat shock proteins (HSPs) are molecular chaperones and have an important role in the refolding and degradation of misfolded proteins, and these functions are related to aging. Rotifer is a useful model organism in aging research, owing to small body size (0.1-1 mm), short lifespan (6-14 days), and senescence phenotypes that can be measured relatively easily. Therefore, we used rotifer as a model to determine the role of four typical hsp genes on the aging process in order to provide a better understanding of rotifer aging. We cloned cDNA encoding hsp genes (hsp40, hsp60, hsp70, and hsp90) from the rotifer Brachionus calyciflorus Pallas, analyzed their molecular characteristics, determined its modulatory response under different temperatures and H 2 O 2 concentrations and investigated the changes in expression of these genes during the aging process. We found that Bchsp70 mRNA expression significantly decreased with aging. In addition, we also studied the effects of dietary restriction (DR) and vitamin E on rotifer lifespan and reproduction and analyzed the changes in expression of these four Bchsp genes in rotifers treated with DR and vitamin E. The results showed that DR extended the lifespan of rotifers and reduced their fecundity, whereas vitamin E had no significant effect on rotifer lifespan or reproduction. Real-time PCR indicated that DR increased the expression of these four Bchsps. However, vitamin E only improved the expression of Bchsp60, and reduced the expression of Bchsp40, Bchsp70, and Bchsp90. DR pretreatment also increased rotifer survival rate under paraquat-induced oxidative stress. These results indicated that hsp genes had an important role in the anti-aging process.

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Section: Discussionmentioning

confidence: 74%

Changes in the expression of four heat shock proteins during the aging process in Brachionus calyciflorus (rotifera)

Yang

Dong

et al. 2014

Cell Stress and Chaperones

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“…The mechanism of iron toxicity is likely related to promotion of damaging free-radical reactions and associated inflammation (Smith et al, 1997) (reviewed in Kell, 2009). It is thus not surprising that invertebrate data (Drosophila) suggest that age-related iron accumulation is proportional to the rate of aging (Massie et al, 1985) and inhibition of iron absorption prolongs lifespan (Massie et al, 1993). Similarly, human gender differences in longevity have been proposed to relate to reproduction-related iron losses in women (Sullivan, 1989) and life-extending effects of calorie restriction have been associated with reduced dietary iron uptake and lowered iron deposits in tissue (Cook and Yu, 1998;Kastman et al, 2010;Valle et al, 2008;Xu et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Gender and Iron Genes May Modify Associations Between Brain Iron and Memory in Healthy Aging

Bartzokis

Tingus

et al. 2011

Neuropsychopharmacol

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Brain iron increases with age and is abnormally elevated early in the disease process in several neurodegenerative disorders that impact memory including Alzheimer's disease (AD). Higher brain iron levels are associated with male gender and presence of highly prevalent allelic variants in genes encoding for iron metabolism proteins (hemochromatosis H63D (HFE H63D) and transferrin C2 (TfC2)). In this study, we examined whether in healthy older individuals memory performance is associated with increased brain iron, and whether gender and gene variant carrier (IRON + ) vs noncarrier (IRONÀ) status (for HFE H63D/TfC2) modify the associations. Tissue iron deposited in ferritin molecules can be measured in vivo with magnetic resonance imaging utilizing the field-dependent relaxation rate increase (FDRI) method. FDRI was assessed in hippocampus, basal ganglia, and white matter, and IRON + vs IRONÀ status was determined in a cohort of 63 healthy older individuals. Three cognitive domains were assessed: verbal memory (delayed recall), working memory/attention, and processing speed. Independent of gene status, worse verbal-memory performance was associated with higher hippocampal iron in men (r ¼ À0.50, p ¼ 0.003) but not in women. Independent of gender, worse verbal working memory performance was associated with higher basal ganglia iron in IRONÀ group (r ¼ À0.49, p ¼ 0.005) but not in the IRON + group. Between-group interactions (p ¼ 0.006) were noted for both of these associations. No significant associations with white matter or processing speed were observed. The results suggest that in specific subgroups of healthy older individuals, higher accumulations of iron in vulnerable gray matter regions may adversely impact memory functions and could represent a risk factor for accelerated cognitive decline. Combining genetic and MRI biomarkers may provide opportunities to design primary prevention clinical trials that target high-risk groups.

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“…Readers are directed to some recent reviews on intervention studies in overall aging and lifespan extension. A list of interventional strategies ranging from antioxidant administration to CR that have been attempted to modulate life span in various organisms and in human cells, ex vivo, and their ability to extend life span is provided in Table 1 (18,33,88,137,148,149,167,172,183,209,227,321,387,392,395). A few of these interventions, in the context of immune aging are discussed below.…”

Section: Ponnappan and Ponnappanmentioning

confidence: 99%

Aging and Immune Function: Molecular Mechanisms to Interventions

Ponnappan

2011

Antioxidants & Redox Signaling

290

266

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The immune system of an organism is an essential component of the defense mechanism aimed at combating pathogenic stress. Age-associated immune dysfunction, also dubbed ''immune senescence,'' manifests as increased susceptibility to infections, increased onset and progression of autoimmune diseases, and onset of neoplasia. Over the years, extensive research has generated consensus in terms of the phenotypic and functional defects within the immune system in various organisms, including humans. Indeed, age-associated alterations such as thymic involution, T cell repertoire skewing, decreased ability to activate naïve T cells and to generate robust memory responses, have been shown to have a causative role in immune decline. Further, understanding the molecular mechanisms underlying the generation of proteotoxic stress, DNA damage response, modulation of ubiquitin proteasome pathway, and regulation of transcription factor NFkB activation, in immune decline, have paved the way to delineating signaling pathways that cross-talk and impact immune senescence. Given the role of the immune system in combating infections, its effectiveness with age may well be a marker of health and a predictor of longevity. It is therefore believed that a better understanding of the mechanisms underlying immune senescence will lead to an effective interventional strategy aimed at improving the health span of individuals. Antioxid. Redox Signal. 14, 1551-1585.

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Inhibition of iron absorption prolongs the life span of Drosophila

Cited by 55 publications

References 22 publications

Changes in the expression of four heat shock proteins during the aging process in Brachionus calyciflorus (rotifera)

Changes in the expression of four heat shock proteins during the aging process in Brachionus calyciflorus (rotifera)

Gender and Iron Genes May Modify Associations Between Brain Iron and Memory in Healthy Aging

Aging and Immune Function: Molecular Mechanisms to Interventions

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