Inhibition of lipoxygenase by sesamol corroborates its potential anti-inflammatory activity

Yashaswini, P.S.; Rao, A. G. Appu; Singh, Sridevi Annapurna

doi:10.1016/j.ijbiomac.2016.06.048

Cited by 44 publications

(25 citation statements)

References 29 publications

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“…HHP promotes membrane disruption, followed by leaching of the substrate and enzyme and direct contact between them, favoring the enzyme reaction, which can be enhanced or minimized by pressure depending on the HHP parameters and catalytic agents . On the other hand, UV‐C radiation induces the release of electrons and consequently converts Fe 2+ to Fe 3+ , which is a catalyst of lipid oxidation via lipoxygenase . We suggest that the protective effect of HHP against lipoxygenase activity may have been impaired by the UV‐C effect on the iron‐oxidation pathway.…”

Section: Resultsmentioning

confidence: 94%

Synergistic effect of ultraviolet radiation and high hydrostatic pressure on texture, color, and oxidative stability of refrigerated tilapia fillets

et al. 2019

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BACKGROUND: The isolated application of high hydrostatic pressure (HHP) and ultraviolet-C (UV-C) radiation may induce physicochemical changes, thus jeopardizing fish quality attributes during refrigerated storage, which could be minimized by the use of synergistic treatments. Therefore, this study investigated the combined effect of UV-C at 0.103 ± 0.002 J cm −2 and HHP at 220 MPa for 10 min on quality parameters of tilapia fillets stored at 4 ∘ C for 15 days. RESULTS: HHP and UV-C+HHP showed higher myoglobin concentration, higher metmyoglobin-reducing activity, and lowera* than control and the UV-C treatment (P < 0.05), reaching 2.49, 2.58, 1.62, 1.54 mg myoglobin g −1 , 13.30, 13.81, 2.29, 2.29%, and 2.32, 2.58, 4.29, 3.98 respectively on the last day of storage. UV-C, HHP, and UV-C+HHP increased water-holding capacity and decreased the pH levels, hardness, and chewiness (P < 0.05). HHP retarded lipid oxidation and UV-C increased protein oxidation compared with control (P < 0.05), achieving 0.81 and 2.80 mg malondialdehyde per kilogram of fish tissue, and 5.50 and 4.15 nmol carbonyl per milligram of protein respectively on 15th day of the storage.CONCLUSION: Both technologies (alone or together) enhanced texture parameters and water-holding capacity. UV-C did not induce color changes and lipid oxidation, whereas HHP showed high potential to prevent meat discoloration, lipid oxidation, and protein oxidation. In addition, this combination of methods could be an alternative to prevent protein oxidation induced by UV-C. WHCIn all treatments, the WHC decreased as the storage period increased ( Table 2). The decrease in WHC during the storage time J Sci Food Agric 2019; 99: 4474-4481

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Section: Resultsmentioning

confidence: 94%

Synergistic effect of ultraviolet radiation and high hydrostatic pressure on texture, color, and oxidative stability of refrigerated tilapia fillets

et al. 2019

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“…In the study of kinetic inhibition [113], sesamol competitively inhibits LOX with IC50 value of 51.84 µM and an inhibitory constant (K i ) of 4.9 µM. The competitive inhibition is happening in either the active substrate site or the active metal ion site.…”

Section: Lung Diseasementioning

confidence: 99%

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Aquino

Barbaza

et al. 2019

Molecules

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The use of foodstuff as natural medicines has already been established through studies demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and pharmacological significance of foods enables the understanding of their role against several diseases. Among the foods that can potentially be considered as medicine, is sesame or Sesamum indicum L., which is part of the Pedaliaceae family and is composed of its lignans such as sesamin, sesamol, sesaminol and sesamolin. Its lignans have been widely studied and are known to possess antiaging, anticancer, antidiabetes, anti-inflammatory and antioxidant properties. Modern chronic diseases, which can transform into clinical diseases, are potential targets of these lignans. The prime example of chronic diseases is rheumatic inflammatory diseases, which affect the support structures and the organs of the body and can also develop into malignancies. In line with this, studies emphasizing the anti-inflammatory and anticancer activities of sesame have been discussed in this review.

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“…Sesamin is another prominent compound reported in SO that possesses significant protective effects against oxidative stress in animal model including through ameliorate SOD, GPx, reduction of malondialdehyde and elevated different liver marker, TBARS, and lipid peroxidation as well as reduction of superoxide production (Ahmad et al, ; Chen, Ying, Chen, Zhang, & Zhang, ; Hou, Chang, & Jeng, ; Hsieh et al, ; Jeng & Hou, ; Jnaneshwari et al, ; Nakai et al, ; Tian & Guo, ; Zhang et al, ). In vitro studies of sesamin especially in neuronal cell line (PC12), it showed reduction of reactive oxygen species (ROS) generation especially NO production (Cao et al, ; Duarte, Chenet, de Almeida, Andrade, & de Oliveira, ; Lee et al, ; Yashaswini, Rao, & Singh, ). However, Hou et al () reported that 10‐μM sesamin derivative, 3‐bis (3‐methoxybenzyl) butane‐1, 4‐diol, inhibits lactate dehydrogenase, lipid peroxidation, and apoptosis as well as increases ACh release and also prevents cell damage, scavenges ROS, and attenuates the elevation of intracellular free Ca 2+ ion on Aβ‐stressed PC12 cells (Hou et al, ).…”

Section: Resultsmentioning

confidence: 99%

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

Afroz

Zihad

Uddin

et al. 2019

Phytotherapy Research

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Traditionally, sesame oil (SO) has been used as a popular food and medicine. The review aims to summarize the antioxidant and antiinflammatory effects of SO and its identified compounds as well as further fatty acid profiling and molecular docking study to correlate the interaction of its identified constituents with cyclooxygenase-2 (COX-2). For this, a literature study was made using Google Scholar, Pubmed, and SciFinder databases. Literature study demonstrated that SO has potential antioxidant and antiinflammatory effects in various test systems, including humans, animals, and cultured cells through various pathways such as inhibition of COX, nonenzymatic defense mechanism, inhibition of proinflammatory cytokines, NF-kB or mitogenactivated protein kinase signaling, and prostaglandin synthesis pathway. Fatty acid analysis of SO using gas chromatography identified known nine fatty acids. In silico study revealed that sesamin, sesaminol, sesamolin, stigmasterol, Δ5-avenasterol, and Δ7-avenasterol (−9.6 to −10.7 kcal/mol) were the most efficient ligand for interaction and binding with COX-2. The known fatty acid also showed binding efficiency with COX-2 to some extent (−6.0 to −8.4 kcal/mol). In summary, it is evident that SO may be one of promising traditional medicines that we could use in the prevention and management of diseases associated with oxidative stress and inflammation.

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Inhibition of lipoxygenase by sesamol corroborates its potential anti-inflammatory activity

Cited by 44 publications

References 29 publications

Synergistic effect of ultraviolet radiation and high hydrostatic pressure on texture, color, and oxidative stability of refrigerated tilapia fillets

Synergistic effect of ultraviolet radiation and high hydrostatic pressure on texture, color, and oxidative stability of refrigerated tilapia fillets

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

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