Inhibition of Mast Cell Histamine Release by Flavonoids and Biflavonoids

Abstract

The effect of 11 flavonoids and 4 biflavonoids on the release of histamine from peritoneal rat mast cells induced by compound 48/80 and calcium ionophore A23187 was studied. Dihydroflavonoids (flavanones) and (+)-catechin did not modify histamine release induced by both secretagogues. Flavone, apigenin and cromoglycate inhibited the secretion elicited by compound 48/80 but did not modify the A23187-induced secretion. The effect of kaempferol on the compound 48/80-induced histamine release was biphasic. Low doses (10 (-6) to 10 (-5)M) of the compound potentiated secretion whereas higher doses inhibited histamine secretion. Some of the drugs tested revealed a higher potency as referred to quercetin. Luteolin, a tetrahydroxyflavone and amentoflavone, a biapigenin, exhibited the highest inhibitory effects of mast cell histamine secretion.

Effects of Dietary Supplementation of Yacon By-products and Mugwort Powder on Carcass Characteristics and Meat Quality of Chicken Thigh Meat

“…지방의 산패 정도를 측정하는 TBARS는 대조구보다 야콘 부산물과 쑥 분말 급여구에서 낮았으며(P<0.05), 야콘 부산 물과 쑥 분말의 급여는 지방의 산화를 억제하고, 야콘 부산 (Amella et al, 1985;Hsieh and Yen, 2000). 식물체에는 다양한 형태의 항산화 물질을 함유하고 있으며 (Masuda et al, 1993), 그 중 에서 페놀성 물질은 항산화성을 가진 대표적인 물질로 보고 되고 있다.…”

Synthesis of Ochnaflavone and Its Inhibitory Activity on PGE2Production

“…Although a wealth of biflavonoids have been discovered from various plant species, their biological and pharmacological data are limited. Previously, certain biflavonoids were reported to inhibit phosphodiesterase, 1 lens aldose reductase, 2 mast cell histamine release 3 and to show anticancer activity. 4 Recently, some C-C and C-O-C biflavonoids were synthesized and their anti-microbial 5 and anti-inflammatory 6,7 activities were demonstrated.…”

Ochnaflavone, a Natural Biflavonoid, Induces Cell Cycle Arrest and Apoptosis in HCT-15 Human Colon Cancer Cells

“…Biflavonoid, a dimer of flavonoid, is generally found in the plants of gymnosperms, and the limited pharmacological activities including inhibition of phosphodiestrase, aldose reductase of lens, and histamine release by mast cell were reported (Beretz et al, 1979;Amella et al, 1985;Iwu et al, 1990).…”