Inhibition of methanol metabolism in mice with acetyl salicylic acid

Inhibition of ethanol toxicity by lysine orotate (ORL)

“…However, the protection by acetyl-salicyclic acid (0.5 g/kg) injected i.p. one hour before the LDso of methanol in mice is due to inhibition of the peroxidase systems (xanthine-oxidase, monoamino-oxidase) [8] . In view of the very high rate of ethanol oxidation in mice especially after lethal and toxic doses [9], the effect of orotate may be additive.…”